Adrenergic system and TMS plasticity protocols
| Study | Design (n) | Age, yr* | Male, % | Protocol | Drug (dose) | TMS target | Mechanism of action | Effect |
|---|---|---|---|---|---|---|---|---|
| Healthy participants | ||||||||
| Korchounov and Ziemann (72) | C/O (8) | 19–26 | 62.5 | PAS(N20) + 2 ms | Methylphenidate (40 mg) | M1 | Adrenergic and dopaminergic reuptake inhibitor | No effect |
| Korchounov and Ziemann (72) | C/O (8) | 19–26 | 62.5 | PAS(N20) + 2 ms | Prazosin (1 mg) | M1 | α-1 antagonist | Blocked LTP-like |
C/O = crossover; LTP = long-term potentiation; M1 = motor cortex; PAS = paired associative stimulation; TMS = transcranial magnetic stimulation.
↵* Data are expressed as a range.