Serotonergic system and TMS plasticity protocols
| Study | Design (n) | Age, yr* | Male, % | Protocol | Drug (dose) | TMS target | Mechanism of action | Effect |
|---|---|---|---|---|---|---|---|---|
| Healthy participants | ||||||||
| Batsikadze et al. (85) | C/O (14) | 28.1 ± 4.7 | 50 | PAS25 PAS10 | Citalopram (20 mg) | M1 | SRI | Increased PAS25 LTP-like; reduced PAS10 LTD-like |
C/O = crossover; LTD = long-term depression; LTP = long-term potentiation; M1 = motor cortex; PAS = paired associative stimulation; SRI = serotonin reuptake inhibitor; TMS = transcranial magnetic stimulation.
↵* Data are presented as mean ± standard deviation.