User profiles for Yu Tian Wang
 | Yu Tian WangUniversity of British Columbia Verified email at brain.ubc.ca Cited by 43952 |
Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity
Activation of N-methyl-d-aspartate subtype glutamate receptors (NMDARs) is required for
long-term potentiation (LTP) and long-term depression (LTD) of excitatory synaptic …
long-term potentiation (LTP) and long-term depression (LTD) of excitatory synaptic …
Hippocampal long-term depression is required for the consolidation of spatial memory
Although NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) and long-term
depression (LTD) of glutamatergic transmission are candidate mechanisms for long-term …
depression (LTD) of glutamatergic transmission are candidate mechanisms for long-term …
Regulation of NMDA receptors by tyrosine kinases and phosphatases
PROTEIN-TYROSINE kinases (PTKs) and protein-tyrosine phosphatases (PTPs) are key
enzymes in signal-transduction pathways for a wide range of cellular processes 1,2 . PTKs and …
enzymes in signal-transduction pathways for a wide range of cellular processes 1,2 . PTKs and …
[HTML][HTML] Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons
Long-term potentiation (LTP) of excitatory transmission in the hippocampus likely contributes
to learning and memory. The mechanisms underlying LTP at these synapses are not well …
to learning and memory. The mechanisms underlying LTP at these synapses are not well …
Mutation of GABRA1 in an autosomal dominant form of juvenile myoclonic epilepsy
…, L Carmant, A Verner, WY Lu, YU Tian Wang… - Nature …, 2002 - nature.com
Although many genes that predispose for epilepsy in humans have been determined, those
that underlie the classical syndromes of idiopathic generalized epilepsy (IGE) have yet to be …
that underlie the classical syndromes of idiopathic generalized epilepsy (IGE) have yet to be …
NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo
…, J Lu, M Tymianski, AM Craig, YT Wang - Journal of …, 2007 - Soc Neuroscience
Well-documented experimental evidence from both in vitro and in vivo models of stroke
strongly supports the critical involvement of NMDA receptor-mediated excitotoxicity in neuronal …
strongly supports the critical involvement of NMDA receptor-mediated excitotoxicity in neuronal …
Glycine binding primes NMDA receptor internalization
NMDA (N-methyl-d-aspartate) receptors (NMDARs) are a principal subtype of excitatory
ligand-gated ion channel with prominent roles in physiological and disease processes in the …
ligand-gated ion channel with prominent roles in physiological and disease processes in the …
[HTML][HTML] Regulation of AMPA receptor–mediated synaptic transmission by clathrin-dependent receptor internalization
Redistribution of postsynaptic AMPA- (α-amino-3-hydroxy-5-methylisoxazole-4-propionic
acid–) subtype glutamate receptors may regulate synaptic strength at glutamatergic synapses, …
acid–) subtype glutamate receptors may regulate synaptic strength at glutamatergic synapses, …
[PDF][PDF] Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons
Hippocampal CA1 homosynaptic long-term potentiation (LTP) is expressed specifically at
activated synapses. Increased insertion of postsynaptic α-amino-3-hydroxy-5-methyl-isoxazole-…
activated synapses. Increased insertion of postsynaptic α-amino-3-hydroxy-5-methyl-isoxazole-…
Direct protein–protein coupling enables cross-talk between dopamine D5 and γ-aminobutyric acid A receptors
GABA A (γ-aminobutyric-acid A) and dopamine D1 and D5 receptors represent two structurally
and functionally divergent families of neurotransmitter receptors. The former comprises a …
and functionally divergent families of neurotransmitter receptors. The former comprises a …
