[HTML][HTML] Chronic caffeine consumption curbs rTMS-induced plasticity

M Vigne, J Kweon, P Sharma, BD Greenberg… - Frontiers in …, 2023 - frontiersin.org
Background Caffeine is a widely used psychostimulant. In the brain, caffeine acts as a
competitive, non-selective adenosine receptor antagonist of A1 and A2A, both known to modulate …

Pharmacological adjuncts and transcranial magnetic stimulation-induced synaptic plasticity: a systematic review

MN Sohn, JC Brown, P Sharma, U Ziemann… - Journal of Psychiatry and …, 2024 - jpn.ca
Background: Transcranial magnetic stimulation (TMS) is a noninvasive neurostimulation
modality that has been used to study human synaptic plasticity. Leveraging work in ex vivo …

[HTML][HTML] Histologic growth patterns in clear cell renal cell carcinoma stratify patients into survival risk groups

…, B Haaland, N Sayegh, H Li, N Rathi, P Sharma… - Clinical Genitourinary …, 2022 - Elsevier
Genomic and morphologic heterogeneity in clear cell renal cell carcinoma (ccRCC) presents
a barrier to prognostication and treatment decisions. Data from pathology are used with …

Comparing Plasticity Effects of iTBS and 10-Hz rTMS with NMDA and GABA Receptor Modulation

P Sharma, M Vigne, J Kweon… - Brain Stimulation: Basic …, 2023 - brainstimjrnl.com
Background: Little is known about the comparative neuronal mechanisms of intermittent
theta-burst stimulation (iTBS) and 10-Hz repetitive transcranial magnetic stimulation (rTMS). We …

Pharmacologically probing purported mechanisms of TMS

…, J Kweon, M Vigne, P Sharma - Brain Stimulation: Basic …, 2023 - brainstimjrnl.com
The network-level changes that drive human behavior are most likely subserved by changes
at the synapse. The strengthening of synaptic connections can be accomplished through …

Comprehensive genomic profiling of matched primary prostate cancer tissue and cell-free DNA (cfDNA) to assess ontogeny of BRCA1/BRCA2 mutations.

…, U Swami, N Sayegh, A Kessel, P Sharma… - 2021 - ascopubs.org
166 Background: Both olaparib and rucaparib have recently been approved for the treatment
of metastatic castration resistant prostate cancer (mCRPC) with BRCA1/2 mutations (…

79. Lifestyle Influences on Plasticity: A Covariate Pharmaco-rTMS Analysis

…, J Kweon, M Vigne, P Sharma… - Biological …, 2023 - biologicalpsychiatryjournal.com
Background Human pharmaco-rTMS neurophysiology studies aimed at understanding TMS
mechanisms suffer from high inter-individual variability, but contributing factors are not well-…

Genomic alterations in visceral versus nonvisceral “metastatic” site tumor tissue in metastatic prostate cancer (mPC).

…, TR McFarland, AW Hahn, D Sirohi, P Sharma… - 2020 - ascopubs.org
167 Background: Men with mPC with visceral metastasis, as compared to non-visceral disease
have inferior outcomes regardless of therapy (PMID: 25403629). Herein, we hypothesize …

Association of serum iron and response to immune checkpoint inhibitors (ICIs) in metastatic clear cell renal cell carcinoma (mccRCC).

…, N Agarwal, AW Hahn, D Sirohi, P Sharma… - 2020 - ascopubs.org
723 Background: ICIs have improved survival in mRCC patients (pts), yet response rates (RR)
to these treatments are variable. Biomarkers predictive of response to ICIs may improve …

Expert consensus on brain stimulation competencies in postgraduate medical education

AM Burhan, KSP Lai, R Waxman - Brain Stimulation: Basic …, 2023 - brainstimjrnl.com
Despite their important role in treating psychiatric illnesses, brain stimulation interventions
are not taught uniformly in psychiatric postgraduate programs, which affects access to high …