Mrazek et al. (175) | 5-HTTLPR | Citalopram | White non-Hispanic: Int2 VNTRs 12/12 and LL genotype ↑ remission | 25 | 1914 |
Yoshimura et al. (186) | 5-HTTLPR | Paroxetine | No association | 21 | 60 |
Gressier et al. (213) | 5-HTTLPR | Various antidepressants | In females L allele ↑ response | 19 | 103 |
Min et al. (191) | 5-HTTLPR | SSRI, SNRI | 5-HTTLPR L/L or STin2 12/12 genotype ↑ response to SSRI | 25 | 657 |
Huezo-Diaz et al. (174) | 5-HTTLPR | Escitalopram, nortriptyline | L allele ↑ response to escitalopram, > effect in males | 20 | 795 |
Capozzo et al. (214) | 5-HTTLPR | Citalopram | l/l carriers ↑ response | 8 | 21 |
Maron et al. (180) | 5-HTTLPR | Escitalopram | No associations in response S allele ↑ severe headache | 20 | 135 |
Wilkie et al. (179) | 5-HTTLPR | Paroxetine | SLC6A4 intron 2 repeat homozygosis ↓ remission and response | 11 | 163 |
Benedetti et al. (194) | 5-HTTLPR | Lithium augmentation | s/s genotype ↑ response | 21 | 161 |
Bozina et al. (173) | 5-HTTLPR | Paroxetine | L allele and STin2 10/10 ↑ response | 21 | 130 |
Dogan et al. (178) | 5-HTTLPR | Sertraline | No association | NA | 64 |
Ferreira et al. (215) | 5-HTTLPR | Various | L allele ↓ switch into a manic episode | 9 | 112 |
Oberlander et al. (196) | 5-HTTLPR | SSRIs exposed neonates | l/l genotype ↑ respiratory symptoms (respiratory distress and rapid breathing) s/s genotype ↑ neuromotor symptoms | 13 | 37 |
Lotrich et al. (192) | 5-HTTLPR | Paroxetine | In s carriers paroxetine concentrations ↑ response (elderly population) | 16 | 110 |
Schillani et al. (216) | 5-HTTLPR | Sertraline | L carriers ↑ response | 10 | 11 |
Smits et al. (163) | 5-HTTLPR | Various SSRIs | In female s-allele ↓ response | 13 | 214 |
Stamm et al. (193) | 5-HTTLPR | Lithium augmentation | s/s genotype ↑ response | 14 | 55 |
Tanaka et al. (217) | 5-HTTLPR | Paroxetine | No association with iatrogenic nausea | 15 | 72 |
Kang et al. (181) | 5-HTTLPR | Mirtazapine | s/s genotype ↑ response | 18 | 101 |
Kirchheiner et al. (218) | 5-HTTLPR | Various | No association | 19 | 77 |
Kronenberg et al. (219) | 5-HTTLPR | Citalopram | In children l /l genotype ↑ response | 24 | 312 |
Hu et al. (177) | 5-HTTLPR | Citalopram | L(A) allele ↑ side effects | 19 | 1655 |
Kim et al. (184) | 5-HTTLPR | Fluoxetine sertraline notriptyline | STin2 12/12 ↑ response to SSRIs S allele ↑ response to SSRIs and to nortriptyline | 19 | 208 |
Masoliver et al. (220) | 5-HTTLPR | Various antidepressants | s alleles ↑ manic switch | 8 | 188 |
Ng et al. (221) | 5-HTTLPR | Sertraline | No association with response and side effects | 16 | 35 |
Smeraldi et al. (208) | 5-HTTLPR | Fluvoxamine | l allele ↑ response 16F *l ↑ partial response 16D *l ↑ response | 21 | 228 |
Popp et al. (206) | 5-HTTLPR | Various | STin2 10/10 ↑ side effects s/s genotype ↑ side effects | 9 | 109 |
Hong et al. (83) | 5-HTTLPR | Fluoxetine | l/l genotype ↑ response | 15 | 224 |
Kato et al. (190) | 5-HTTLPR | Fluoxetine paroxetine | l/l genotype ↑ response | 17 | 100 |
Kraft et al. (207) | 5-HTTLPR | Fluoxetine | rs25531 ↑ response | 16 | 96 |
Kato et al. (189) | 5-HTTLPR | Fluvoxamine paroxetine | l allele ↑ response to fluvoxamine | 18 | 81 |
Arias et al. (222) | 5-HTTLPR | Citalopram | S/S-G/G haplotype ↓ remission | 18 | 130 |
Serretti et al. (119) | 5-HTTLPR | Various | No association | 22 | 185 |
Yoshida et al. (185) | 5-HTTLPR | Milnacipram | No association | 17 | 96 |
Serretti et al. (120) | 5-HTTLPR | Fluvoxamine, paroxetine | s/s genotype ↓ response | 22 | 221 |
Serretti et al. (223) | 5-HTTLPR | Various antidepressants | No association with manic switch | 17 | 416 |
Lee et al. (188) | 5-HTTLPR | Long-term antidepressants | s/s genotype ↓ response | 12 | 128 |
Peters et al. (85) | 5-HTTLPR | Fluoxetine | rs25533 in STin2 ↑ response | 19 | 96 |
Murphy et al. (171) | 5-HTTLPR | Paroxetine, mirtazapine | l allele ↑ response and ↓ side effects to paroxetine but ↑ side effects to mirtazapine | 18 | 246 |
Durham et al. (172) | 5-HTTLPR | Sertraline | S allele ↓ response | 18 | 206 |
Arias et al. (169) | 5-HTTLPR | Citalopram | s/s genotype ↓ remission | 18 | 131 |
Joyce et al. (170) | 5-HTTLPR | Fluoxetine, nortriptyline | < 25 yr: no association > 25 yr: s/s genotype ↓ response | 15 | 139 |
Perlis et al. (224) | 5-HTTLPR | Fluoxetine | s/s genotype ↑ response s allele ↑ insomnia or agitation | 19 | 36 |
Rousseva et al. (225) | 5-HTTLPR | Antidepressants | No association with manic switch | 12 | 305 |
Takahashi et al. (121) | 5-HTTLPR | Fluvoxamine | No association with fluvoxamine induced nausea | 21 | 54 |
Yu et al. (187) | 5-HTTLPR | Fluoxetine | l/l genotype ↑ response | 15 | 121 |
Rausch et al. (168) | 5-HTTLPR | Fluoxetine | l/l subjects ↑ rapid response | 19 | 51 |
Ito et al. (205) | 5-HTTLPR | Fluvoxamine | No association (STin2) | 15 | 54 |
Yoshida et al. (183) | 5-HTTLPR | Fluvoxamine | s allele ↑ response | 14 | 54 |
Zanardi et al. (166) | 5-HTTLPR | Fluvoxamine | l allele ↑ response | 21 | 64 |
Arias et al. (226) | 5-HTTLPR | Citalopram | s/s genotype ↓ response | 18 | 269 |
Mundo et al. (227) | 5-HTTLPR | SSRI, TCA | s allele ↑ manic or hypomanic switch | 15 | 27 |
Minov et al. (176) | 5-HTTLPR | Various antidepressants | No association | 9 | 104 |
Serretti et al. (77) | 5-HTTLPR | Fluvoxamine | l allele ↑ response | 22 | 217 |
Zanardi et al. (165) | 5-HTTLPR | Paroxetine | s allele ↓ response | 18 | 58 |
Pollock et al. (167) | 5-HTTLPR | Paroxetine | s allele ↑ slower response | 16 | 57 |
Kim et al. (182) | 5-HTTLPR | Fluoxetine, paroxetine | s/s genotype and L/L in intron ↑ response | 14 | 120 |
Smeraldi et al. (164) | 5-HTTLPR | Fluvoxamine | l allele ↑ response | 16 | 53 |