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Research Papers

Abnormal interhemispheric connectivity in male psychopathic offenders

Sylco S. Hoppenbrouwers, Danilo R. De Jesus, Yinming Sun, Tania Stirpe, Dennis Hofman, Jeff McMaster, Ginny Hughes, Zafiris J. Daskalakis and Dennis J.L.G. Schutter
J Psychiatry Neurosci January 01, 2014 39 (1) 22-30; DOI: https://doi.org/10.1503/jpn.120046
Sylco S. Hoppenbrouwers
Hoppenbrouwers, Hofman, Schutter — Department of Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, the Netherlands; de Jesus, Sun, Daskalakis — Centre for Addiction and Mental Health, Schizophrenia program, Toronto, Ont.; Stirpe, Hughes — Correctional Service of Canada, Central Ontario District (Parole), Psychology Department, Toronto, Ont.; McMaster — Centre for Addiction and Mental Health; Law and Mental Health Program, Toronto, Ont., Canada
PhD
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Danilo R. De Jesus
Hoppenbrouwers, Hofman, Schutter — Department of Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, the Netherlands; de Jesus, Sun, Daskalakis — Centre for Addiction and Mental Health, Schizophrenia program, Toronto, Ont.; Stirpe, Hughes — Correctional Service of Canada, Central Ontario District (Parole), Psychology Department, Toronto, Ont.; McMaster — Centre for Addiction and Mental Health; Law and Mental Health Program, Toronto, Ont., Canada
MD
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Yinming Sun
Hoppenbrouwers, Hofman, Schutter — Department of Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, the Netherlands; de Jesus, Sun, Daskalakis — Centre for Addiction and Mental Health, Schizophrenia program, Toronto, Ont.; Stirpe, Hughes — Correctional Service of Canada, Central Ontario District (Parole), Psychology Department, Toronto, Ont.; McMaster — Centre for Addiction and Mental Health; Law and Mental Health Program, Toronto, Ont., Canada
MSc
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Tania Stirpe
Hoppenbrouwers, Hofman, Schutter — Department of Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, the Netherlands; de Jesus, Sun, Daskalakis — Centre for Addiction and Mental Health, Schizophrenia program, Toronto, Ont.; Stirpe, Hughes — Correctional Service of Canada, Central Ontario District (Parole), Psychology Department, Toronto, Ont.; McMaster — Centre for Addiction and Mental Health; Law and Mental Health Program, Toronto, Ont., Canada
PhD
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Dennis Hofman
Hoppenbrouwers, Hofman, Schutter — Department of Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, the Netherlands; de Jesus, Sun, Daskalakis — Centre for Addiction and Mental Health, Schizophrenia program, Toronto, Ont.; Stirpe, Hughes — Correctional Service of Canada, Central Ontario District (Parole), Psychology Department, Toronto, Ont.; McMaster — Centre for Addiction and Mental Health; Law and Mental Health Program, Toronto, Ont., Canada
PhD
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Jeff McMaster
Hoppenbrouwers, Hofman, Schutter — Department of Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, the Netherlands; de Jesus, Sun, Daskalakis — Centre for Addiction and Mental Health, Schizophrenia program, Toronto, Ont.; Stirpe, Hughes — Correctional Service of Canada, Central Ontario District (Parole), Psychology Department, Toronto, Ont.; McMaster — Centre for Addiction and Mental Health; Law and Mental Health Program, Toronto, Ont., Canada
MD
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Ginny Hughes
Hoppenbrouwers, Hofman, Schutter — Department of Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, the Netherlands; de Jesus, Sun, Daskalakis — Centre for Addiction and Mental Health, Schizophrenia program, Toronto, Ont.; Stirpe, Hughes — Correctional Service of Canada, Central Ontario District (Parole), Psychology Department, Toronto, Ont.; McMaster — Centre for Addiction and Mental Health; Law and Mental Health Program, Toronto, Ont., Canada
BSc
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Zafiris J. Daskalakis
Hoppenbrouwers, Hofman, Schutter — Department of Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, the Netherlands; de Jesus, Sun, Daskalakis — Centre for Addiction and Mental Health, Schizophrenia program, Toronto, Ont.; Stirpe, Hughes — Correctional Service of Canada, Central Ontario District (Parole), Psychology Department, Toronto, Ont.; McMaster — Centre for Addiction and Mental Health; Law and Mental Health Program, Toronto, Ont., Canada
MD, PhD
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Dennis J.L.G. Schutter
Hoppenbrouwers, Hofman, Schutter — Department of Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, the Netherlands; de Jesus, Sun, Daskalakis — Centre for Addiction and Mental Health, Schizophrenia program, Toronto, Ont.; Stirpe, Hughes — Correctional Service of Canada, Central Ontario District (Parole), Psychology Department, Toronto, Ont.; McMaster — Centre for Addiction and Mental Health; Law and Mental Health Program, Toronto, Ont., Canada
PhD
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  • For correspondence: [email protected]
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  • Fig. 1
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    Fig. 1

    Interhemispheric signal propagation (ISP) per cortical area in psychopathic offenders and healthy controls. DLPFC = dorsolateral prefrontal cortex.

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    Fig. 2

    Psychopathic offenders demonstrate an increase in cortical silent period (CSP) in the right motor cortex.

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    Fig. 3

    The mean amplitude of the cortical evoked potentials is represented at different times (successive lines) in healthy controls (left 2 columns) and psychopathic offenders (right 2 columns). The mean amplitude is colour coded. DLPFC = dorsolateral prefrontal cortex; TMS = transcranial magnetic stimulation.

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    Fig. 4

    Temporal representation of the activity of the prefrontal electrodes, thought to measure dorsolateral prefrontal cortex activity. ISP = inter-hemispheric signal propagation; TMS = transcranial magnetic stimulation.

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    Table 1

    Comparison of the motor threshold and intensity needed to achieve a 1 mV motor-evoked potential amplitude of controls and psychopathic offenders

    Group; mean ± SD
    FactorControlPsychopathyp value
    Without cap
    MT
     Left37.7 ± 5.737.9 ± 5.60.92
     Right40.9 ± 8.742.0 ± 8.70.72
    1 mV
     Left52.0 ± 9.848.4 ± 10.80.34
     Right59.3 ± 15.166.0 ± 18.30.27
    With cap
    MT
     Left53.7 ± 8.752.5 ± 7.40.43
     Right53.1 ± 7.254.0 ± 10.40.88
    1 mV
     Left64.1 ± 10.064.1 ± 11.5> 0.99
     Right67.3 ± 10.372.3 ± 16.70.34
    • MT = motor threshold; SD = standard deviation.

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Journal of Psychiatry and Neuroscience: 39 (1)
J Psychiatry Neurosci
Vol. 39, Issue 1
1 Jan 2014
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Abnormal interhemispheric connectivity in male psychopathic offenders
Sylco S. Hoppenbrouwers, Danilo R. De Jesus, Yinming Sun, Tania Stirpe, Dennis Hofman, Jeff McMaster, Ginny Hughes, Zafiris J. Daskalakis, Dennis J.L.G. Schutter
J Psychiatry Neurosci Jan 2014, 39 (1) 22-30; DOI: 10.1503/jpn.120046

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Abnormal interhemispheric connectivity in male psychopathic offenders
Sylco S. Hoppenbrouwers, Danilo R. De Jesus, Yinming Sun, Tania Stirpe, Dennis Hofman, Jeff McMaster, Ginny Hughes, Zafiris J. Daskalakis, Dennis J.L.G. Schutter
J Psychiatry Neurosci Jan 2014, 39 (1) 22-30; DOI: 10.1503/jpn.120046
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