Supine SBP, mm Hg | | | |
Baseline | 116.3 ± 10.9 | 117.3 ± 11.2 | 116.7 ± 11.2 |
Change at end of double-blind period | 0.1 ± 10.0 | 3.8 ± 9.7 | 2.9 ± 9.0 |
Supine DBP, mm Hg | | | |
Baseline | 74.2 ± 7.5 | 73.5 ± 8.3 | 73.5 ± 8.1 |
Change at end of double-blind period | 0.4 ± 7.8 | 4.3 ± 6.8 | 3.8 ± 7.0 |
Supine pulse rate, beats/min | | | |
Baseline | 70.4 ± 9.7 | 70.8 ± 10.0 | 70.7 ± 9.3 |
Change at end of double-blind period | −0.5 ± 9.3 | 5.4 ± 9.6 | 6.0 ± 10.2 |
Body weight, kg | | | |
Baseline | 81.7 ± 17.8 | 81.2 ± 17.1 | 81.7 ± 17.6 |
Change at end of double-blind period | 0.1 ± 1.8 | −0.5 ± 1.9 | −0.4 ± 1.8 |
Orthostatic hypotension,* no. (%) | 17 (9.3)‡ | 23 (12.4)§ | 17 (9.1)¶ |
Potentially significant change criteria, no. (%) | | | |
Supine SBP (≤ 90 mm Hg and decrease ≥ 20 mm Hg) | 0 | 1 (0.5) | 0 |
Supine DBP (≥ 105 mm Hg and increase ≥ 15 mm Hg) | 0 | 1 (0.5) | 0 |
Supine pulse rate (≤ 50 beats/min and decrease ≥ 15 beats/min) | 1 (0.5) | 0 | 0 |
Body weight, kg (≥ 7% increase) | 0 | 1 (0.5) | 2 (1.1) |
Body weight, kg (≥ 7% decrease) | 0 | 1 (0.5) | 1 (0.5) |