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Research Papers

Impact of acute administration of escitalopram on the processing of emotional and neutral images: a randomized crossover fMRI study of healthy women

Tim Outhred, Pritha Das, Kim L. Felmingham, Richard A. Bryant, Pradeep J. Nathan, Gin S. Malhi and Andrew H. Kemp
J Psychiatry Neurosci July 01, 2014 39 (4) 267-275; DOI: https://doi.org/10.1503/jpn.130118
Tim Outhred
Outhred, Das, Malhi, Kemp — Discipline of Psychiatry, Sydney Medical School, University of Sydney, Royal North Shore Hospital, Australia; Outhred, Kemp — SCAN Research and Teaching Unit, School of Psychology, University of Sydney, Australia; Das, Malhi, Kemp — CADE Clinic, Department of Psychiatry, Royal North Shore Hospital, Australia; Das, Malhi, Kemp — Advanced Research and Clinical Highfield Imaging (ARCHI), University of Sydney, Royal North Shore Hospital, Australia; Felmingham — School of Psychology, University of Tasmania, Hobart, Australia; Bryant — School of Psychology, University of New South Wales, Kensington, Australia; Nathan — Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom; Nathan — School of Psychology and Psychiatry, Monash University, Australia; Kemp — University Hospital, University of São Paulo, São Paulo SP, Brazil
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Pritha Das
Outhred, Das, Malhi, Kemp — Discipline of Psychiatry, Sydney Medical School, University of Sydney, Royal North Shore Hospital, Australia; Outhred, Kemp — SCAN Research and Teaching Unit, School of Psychology, University of Sydney, Australia; Das, Malhi, Kemp — CADE Clinic, Department of Psychiatry, Royal North Shore Hospital, Australia; Das, Malhi, Kemp — Advanced Research and Clinical Highfield Imaging (ARCHI), University of Sydney, Royal North Shore Hospital, Australia; Felmingham — School of Psychology, University of Tasmania, Hobart, Australia; Bryant — School of Psychology, University of New South Wales, Kensington, Australia; Nathan — Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom; Nathan — School of Psychology and Psychiatry, Monash University, Australia; Kemp — University Hospital, University of São Paulo, São Paulo SP, Brazil
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Kim L. Felmingham
Outhred, Das, Malhi, Kemp — Discipline of Psychiatry, Sydney Medical School, University of Sydney, Royal North Shore Hospital, Australia; Outhred, Kemp — SCAN Research and Teaching Unit, School of Psychology, University of Sydney, Australia; Das, Malhi, Kemp — CADE Clinic, Department of Psychiatry, Royal North Shore Hospital, Australia; Das, Malhi, Kemp — Advanced Research and Clinical Highfield Imaging (ARCHI), University of Sydney, Royal North Shore Hospital, Australia; Felmingham — School of Psychology, University of Tasmania, Hobart, Australia; Bryant — School of Psychology, University of New South Wales, Kensington, Australia; Nathan — Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom; Nathan — School of Psychology and Psychiatry, Monash University, Australia; Kemp — University Hospital, University of São Paulo, São Paulo SP, Brazil
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Richard A. Bryant
Outhred, Das, Malhi, Kemp — Discipline of Psychiatry, Sydney Medical School, University of Sydney, Royal North Shore Hospital, Australia; Outhred, Kemp — SCAN Research and Teaching Unit, School of Psychology, University of Sydney, Australia; Das, Malhi, Kemp — CADE Clinic, Department of Psychiatry, Royal North Shore Hospital, Australia; Das, Malhi, Kemp — Advanced Research and Clinical Highfield Imaging (ARCHI), University of Sydney, Royal North Shore Hospital, Australia; Felmingham — School of Psychology, University of Tasmania, Hobart, Australia; Bryant — School of Psychology, University of New South Wales, Kensington, Australia; Nathan — Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom; Nathan — School of Psychology and Psychiatry, Monash University, Australia; Kemp — University Hospital, University of São Paulo, São Paulo SP, Brazil
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Pradeep J. Nathan
Outhred, Das, Malhi, Kemp — Discipline of Psychiatry, Sydney Medical School, University of Sydney, Royal North Shore Hospital, Australia; Outhred, Kemp — SCAN Research and Teaching Unit, School of Psychology, University of Sydney, Australia; Das, Malhi, Kemp — CADE Clinic, Department of Psychiatry, Royal North Shore Hospital, Australia; Das, Malhi, Kemp — Advanced Research and Clinical Highfield Imaging (ARCHI), University of Sydney, Royal North Shore Hospital, Australia; Felmingham — School of Psychology, University of Tasmania, Hobart, Australia; Bryant — School of Psychology, University of New South Wales, Kensington, Australia; Nathan — Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom; Nathan — School of Psychology and Psychiatry, Monash University, Australia; Kemp — University Hospital, University of São Paulo, São Paulo SP, Brazil
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Gin S. Malhi
Outhred, Das, Malhi, Kemp — Discipline of Psychiatry, Sydney Medical School, University of Sydney, Royal North Shore Hospital, Australia; Outhred, Kemp — SCAN Research and Teaching Unit, School of Psychology, University of Sydney, Australia; Das, Malhi, Kemp — CADE Clinic, Department of Psychiatry, Royal North Shore Hospital, Australia; Das, Malhi, Kemp — Advanced Research and Clinical Highfield Imaging (ARCHI), University of Sydney, Royal North Shore Hospital, Australia; Felmingham — School of Psychology, University of Tasmania, Hobart, Australia; Bryant — School of Psychology, University of New South Wales, Kensington, Australia; Nathan — Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom; Nathan — School of Psychology and Psychiatry, Monash University, Australia; Kemp — University Hospital, University of São Paulo, São Paulo SP, Brazil
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Andrew H. Kemp
Outhred, Das, Malhi, Kemp — Discipline of Psychiatry, Sydney Medical School, University of Sydney, Royal North Shore Hospital, Australia; Outhred, Kemp — SCAN Research and Teaching Unit, School of Psychology, University of Sydney, Australia; Das, Malhi, Kemp — CADE Clinic, Department of Psychiatry, Royal North Shore Hospital, Australia; Das, Malhi, Kemp — Advanced Research and Clinical Highfield Imaging (ARCHI), University of Sydney, Royal North Shore Hospital, Australia; Felmingham — School of Psychology, University of Tasmania, Hobart, Australia; Bryant — School of Psychology, University of New South Wales, Kensington, Australia; Nathan — Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom; Nathan — School of Psychology and Psychiatry, Monash University, Australia; Kemp — University Hospital, University of São Paulo, São Paulo SP, Brazil
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  • For correspondence: [email protected] [email protected]
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    Fig. 1

    Percent signal change and regional activation illustrating a treatment-emotion processing interaction (error bars represent standard error of the mean). AMY = amygdala; IFG = inferior frontal gyrus; ROI = region of interest.

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    Table 1

    Peak amygdala and IFG activation of the interaction between treatment and affective experience

    Peak voxel (MNI)
    Group contrast; regionkPeak t value*p value‡xyz
    Interaction effect
     Right IFG2837.91†< 0.00138520
    4.75†0.01040404
    4.21†0.0163844−12
    4.15†0.0174244−10
     Left amygdala505.18†0.006−202−16
    4.79†0.009−20−4−18
    Positive pictures
    Escitalopram > placebo
     Left amygdala562.240.013−200−16
    1.950.025−22−4−22
    Placebo > escitalopram
     Right IFG482.390.00948420
     Left IFG292.050.021−4440−4
    Negative pictures
    Escitalopram > placebo
     Right IFG3493.050.00140542
    2.490.00748542
    2.430.00844422
    2.350.010484610
     Left IFG1152.600.005−44488
    2.310.011−4044−4
    Placebo > escitalopram
     Left amygdala1044.420.006§−26−2−12
    4.330.007§−262−16
     Right amygdala1093.130.001242−12
    3.070.001244−16
    Neutral pictures
    Escitalopram > placebo
     Left IFG1052.900.002−3830−2
     Left IFG702.450.008−361012
    2.140.017−4286
    Placebo > escitalopram
     Right IFG562.630.005582430
    2.170.015561628
    2.000.023502024
    1.870.031482424
     Right IFG301.960.025484014
    1.960.026483818
    1.860.03240408
    1.810.03544448
    1.890.0304246−6
    1.890.0304244−12
    1.890.03038500
    1.840.0334250−2
    • IFG = inferior frontal gyrus; MNI = Montreal Neurological Institute.

    • ↵* Unless otherwise indicated.

    • ↵† F2,210 statistic value.

    • ↵‡ Partial volume, uncorrected p value, k = 20, unless otherwise indicated.

    • ↵§ Partial volume, false-discovery rate–corrected p value.

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Journal of Psychiatry and Neuroscience: 39 (4)
J Psychiatry Neurosci
Vol. 39, Issue 4
1 Jul 2014
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Impact of acute administration of escitalopram on the processing of emotional and neutral images: a randomized crossover fMRI study of healthy women
Tim Outhred, Pritha Das, Kim L. Felmingham, Richard A. Bryant, Pradeep J. Nathan, Gin S. Malhi, Andrew H. Kemp
J Psychiatry Neurosci Jul 2014, 39 (4) 267-275; DOI: 10.1503/jpn.130118

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Impact of acute administration of escitalopram on the processing of emotional and neutral images: a randomized crossover fMRI study of healthy women
Tim Outhred, Pritha Das, Kim L. Felmingham, Richard A. Bryant, Pradeep J. Nathan, Gin S. Malhi, Andrew H. Kemp
J Psychiatry Neurosci Jul 2014, 39 (4) 267-275; DOI: 10.1503/jpn.130118
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