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Research Papers

Resting-state functional connectivity abnormalities in patients with obsessive–compulsive disorder and their healthy first-degree relatives

Jing-Ming Hou, Ming Zhao, Wei Zhang, Ling-Heng Song, Wen-Jing Wu, Jian Wang, Dai-Quan Zhou, Bing Xie, Mei He, Jun-Wei Guo, Wei Qu and Hai-Tao Li
J Psychiatry Neurosci September 01, 2014 39 (5) 304-311; DOI: https://doi.org/10.1503/jpn.130220
Jing-Ming Hou
Hou, Zhao, Zhang, Song, Wu, Wang, Zhou, Xie, Li — Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing; He, Qu, Guo — Department of Clinical Psychology, Southwest Hospital, Third Military Medical University, Chongqing, China
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Ming Zhao
Hou, Zhao, Zhang, Song, Wu, Wang, Zhou, Xie, Li — Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing; He, Qu, Guo — Department of Clinical Psychology, Southwest Hospital, Third Military Medical University, Chongqing, China
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Wei Zhang
Hou, Zhao, Zhang, Song, Wu, Wang, Zhou, Xie, Li — Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing; He, Qu, Guo — Department of Clinical Psychology, Southwest Hospital, Third Military Medical University, Chongqing, China
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Ling-Heng Song
Hou, Zhao, Zhang, Song, Wu, Wang, Zhou, Xie, Li — Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing; He, Qu, Guo — Department of Clinical Psychology, Southwest Hospital, Third Military Medical University, Chongqing, China
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Wen-Jing Wu
Hou, Zhao, Zhang, Song, Wu, Wang, Zhou, Xie, Li — Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing; He, Qu, Guo — Department of Clinical Psychology, Southwest Hospital, Third Military Medical University, Chongqing, China
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Jian Wang
Hou, Zhao, Zhang, Song, Wu, Wang, Zhou, Xie, Li — Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing; He, Qu, Guo — Department of Clinical Psychology, Southwest Hospital, Third Military Medical University, Chongqing, China
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Dai-Quan Zhou
Hou, Zhao, Zhang, Song, Wu, Wang, Zhou, Xie, Li — Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing; He, Qu, Guo — Department of Clinical Psychology, Southwest Hospital, Third Military Medical University, Chongqing, China
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Bing Xie
Hou, Zhao, Zhang, Song, Wu, Wang, Zhou, Xie, Li — Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing; He, Qu, Guo — Department of Clinical Psychology, Southwest Hospital, Third Military Medical University, Chongqing, China
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Mei He
Hou, Zhao, Zhang, Song, Wu, Wang, Zhou, Xie, Li — Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing; He, Qu, Guo — Department of Clinical Psychology, Southwest Hospital, Third Military Medical University, Chongqing, China
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Jun-Wei Guo
Hou, Zhao, Zhang, Song, Wu, Wang, Zhou, Xie, Li — Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing; He, Qu, Guo — Department of Clinical Psychology, Southwest Hospital, Third Military Medical University, Chongqing, China
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Wei Qu
Hou, Zhao, Zhang, Song, Wu, Wang, Zhou, Xie, Li — Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing; He, Qu, Guo — Department of Clinical Psychology, Southwest Hospital, Third Military Medical University, Chongqing, China
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Hai-Tao Li
Hou, Zhao, Zhang, Song, Wu, Wang, Zhou, Xie, Li — Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing; He, Qu, Guo — Department of Clinical Psychology, Southwest Hospital, Third Military Medical University, Chongqing, China
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  • For correspondence: [email protected]
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    Fig. 1

    Whole brain difference of functional connectivity strength maps among 3 groups. The colour bar indicates the statistical significance threshold. The left side of the image corresponds to the left hemispheric regions. Map thresholds were set at p < 0.05 with multiple comparisons. HC = healthy controls; L = left; OCD = obsessive–compulsive disorder; R = right; REL = first-degree relatives of patients with OCD.

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    Fig. 2

    The overlapping regions of abnormal functional connectivity strength in patients with obsessive–compulsive disorder (OCD) and their healthy first-degree relatives. The box plot represents connectivity strength values of the 3 groups at the peak of the overlapping regions. Blue denotes the healthy control group, green denotes the first-degree relative group or abnormal brain regions in first-degree relatives, red denotes patients with OCD or abnormal brain regions in these patients, and yellow denotes the overlapping regions of abnormal functional connectivity strength regions between patients with OCD and their healthy first-degree relatives. *p < 0.001; #p > 0.05. MTG = middle temporal gyrus; OFC = orbitofrontal cortex.

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    Fig. 3

    Abnormal interregional correlations in the patients with obsessive–compulsive disorder (OCD) and their first-degree relatives. Red denotes the brain regions with increased functional connectivity (FC) and blue denotes the brain regions with reduced functional connectivity. Map thresholds were set at p < 0.05 with multiple comparisons. ACC = anterior cingulate cortex; HC = healthy controls; IFG = inferior frontal cortex; L = left; MTG = middle temporal gyrus; OFC = orbitofrontal cortex; PCC = posterior cingulate cortex; PreCG = precentral gyrus; R = right; REL = first-degree relatives of patients with OCD; ROI = region of interest.

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    Table 1

    Demographic and clinical characteristics of the study sample

    Group; mean ± SD*
    CharacteristicsOCD, n = 39Relatives, n = 20Control, n = 39F2,95p value
    Sex, male:female20:1910:1020:190.0960.95
    Age, yr26.6 ± 9.829.5 ± 8.626.0 ± 6.31.3520.27
    Education, yr12.6 ± 3.312.9 ± 2.913.1 ± 3.20.0780.93
    Disease duration, mo45.3 ± 37.3————
    HAM-D total score6.5 ± 5.9————
    HAM-A total score10.2 ± 3.6————
    Y-BOCS total score26.7 ± 6.1————
    • HAM-A = Hamilton Rating Scale for Anxiety; HAM-D = Hamilton Rating Scale for Depression; OCD = obsessive–compulsive disorder; SD = standard deviation; Y-BOCS = Yale–Brown Obsessive Compulsive Scale.

    • ↵* Unless otherwise indicated.

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Journal of Psychiatry and Neuroscience: 39 (5)
J Psychiatry Neurosci
Vol. 39, Issue 5
1 Sep 2014
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Resting-state functional connectivity abnormalities in patients with obsessive–compulsive disorder and their healthy first-degree relatives
Jing-Ming Hou, Ming Zhao, Wei Zhang, Ling-Heng Song, Wen-Jing Wu, Jian Wang, Dai-Quan Zhou, Bing Xie, Mei He, Jun-Wei Guo, Wei Qu, Hai-Tao Li
J Psychiatry Neurosci Sep 2014, 39 (5) 304-311; DOI: 10.1503/jpn.130220

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Resting-state functional connectivity abnormalities in patients with obsessive–compulsive disorder and their healthy first-degree relatives
Jing-Ming Hou, Ming Zhao, Wei Zhang, Ling-Heng Song, Wen-Jing Wu, Jian Wang, Dai-Quan Zhou, Bing Xie, Mei He, Jun-Wei Guo, Wei Qu, Hai-Tao Li
J Psychiatry Neurosci Sep 2014, 39 (5) 304-311; DOI: 10.1503/jpn.130220
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