Research Paper
Voxel-based morphometry analysis reveals frontal brain differences in participants with ADHD and their unaffected siblings
Janita Bralten, Corina U. Greven, Barbara Franke, Maarten Mennes, Marcel P. Zwiers, Nanda N.J. Rommelse, Catharina Hartman, Dennis van der Meer, Laurence O’Dwyer, Jaap Oosterlaan, Pieter J. Hoekstra, Dirk Heslenfeld, Alejandro Arias-Vasquez and Jan K. Buitelaar
J Psychiatry Neurosci July 01, 2016 41 (4) 272-279; DOI: https://doi.org/10.1503/jpn.140377
Janita Bralten
From the Departments of Human Genetics (Bralten, Franke, Arias-Vasquez), Cognitive Neuroscience (Bralten, Greven, Mennes, Zwiers, O’Dwyer, Buitelaar) and Psychiatry (Franke), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; the Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands (Greven, Rommelse, Buitelaar); the Institute of Psychiatry, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK (Greven); the Department of Psychiatry (Rommelse) and Genetics (Arias-Vasquez), Radboud University Medical Center, Nijmegen, the Netherlands; the Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands (Hartman, van der Meer, Hoekstra); and the Departments of Clinical Neuropsychology (Oosterlaan) and Neuropsychiatry (Heslenfeld), VU University, Amsterdam, the Netherlands
Corina U. Greven
From the Departments of Human Genetics (Bralten, Franke, Arias-Vasquez), Cognitive Neuroscience (Bralten, Greven, Mennes, Zwiers, O’Dwyer, Buitelaar) and Psychiatry (Franke), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; the Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands (Greven, Rommelse, Buitelaar); the Institute of Psychiatry, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK (Greven); the Department of Psychiatry (Rommelse) and Genetics (Arias-Vasquez), Radboud University Medical Center, Nijmegen, the Netherlands; the Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands (Hartman, van der Meer, Hoekstra); and the Departments of Clinical Neuropsychology (Oosterlaan) and Neuropsychiatry (Heslenfeld), VU University, Amsterdam, the Netherlands
Barbara Franke
From the Departments of Human Genetics (Bralten, Franke, Arias-Vasquez), Cognitive Neuroscience (Bralten, Greven, Mennes, Zwiers, O’Dwyer, Buitelaar) and Psychiatry (Franke), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; the Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands (Greven, Rommelse, Buitelaar); the Institute of Psychiatry, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK (Greven); the Department of Psychiatry (Rommelse) and Genetics (Arias-Vasquez), Radboud University Medical Center, Nijmegen, the Netherlands; the Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands (Hartman, van der Meer, Hoekstra); and the Departments of Clinical Neuropsychology (Oosterlaan) and Neuropsychiatry (Heslenfeld), VU University, Amsterdam, the Netherlands
Maarten Mennes
From the Departments of Human Genetics (Bralten, Franke, Arias-Vasquez), Cognitive Neuroscience (Bralten, Greven, Mennes, Zwiers, O’Dwyer, Buitelaar) and Psychiatry (Franke), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; the Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands (Greven, Rommelse, Buitelaar); the Institute of Psychiatry, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK (Greven); the Department of Psychiatry (Rommelse) and Genetics (Arias-Vasquez), Radboud University Medical Center, Nijmegen, the Netherlands; the Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands (Hartman, van der Meer, Hoekstra); and the Departments of Clinical Neuropsychology (Oosterlaan) and Neuropsychiatry (Heslenfeld), VU University, Amsterdam, the Netherlands
Marcel P. Zwiers
From the Departments of Human Genetics (Bralten, Franke, Arias-Vasquez), Cognitive Neuroscience (Bralten, Greven, Mennes, Zwiers, O’Dwyer, Buitelaar) and Psychiatry (Franke), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; the Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands (Greven, Rommelse, Buitelaar); the Institute of Psychiatry, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK (Greven); the Department of Psychiatry (Rommelse) and Genetics (Arias-Vasquez), Radboud University Medical Center, Nijmegen, the Netherlands; the Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands (Hartman, van der Meer, Hoekstra); and the Departments of Clinical Neuropsychology (Oosterlaan) and Neuropsychiatry (Heslenfeld), VU University, Amsterdam, the Netherlands
Nanda N.J. Rommelse
From the Departments of Human Genetics (Bralten, Franke, Arias-Vasquez), Cognitive Neuroscience (Bralten, Greven, Mennes, Zwiers, O’Dwyer, Buitelaar) and Psychiatry (Franke), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; the Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands (Greven, Rommelse, Buitelaar); the Institute of Psychiatry, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK (Greven); the Department of Psychiatry (Rommelse) and Genetics (Arias-Vasquez), Radboud University Medical Center, Nijmegen, the Netherlands; the Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands (Hartman, van der Meer, Hoekstra); and the Departments of Clinical Neuropsychology (Oosterlaan) and Neuropsychiatry (Heslenfeld), VU University, Amsterdam, the Netherlands
Catharina Hartman
From the Departments of Human Genetics (Bralten, Franke, Arias-Vasquez), Cognitive Neuroscience (Bralten, Greven, Mennes, Zwiers, O’Dwyer, Buitelaar) and Psychiatry (Franke), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; the Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands (Greven, Rommelse, Buitelaar); the Institute of Psychiatry, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK (Greven); the Department of Psychiatry (Rommelse) and Genetics (Arias-Vasquez), Radboud University Medical Center, Nijmegen, the Netherlands; the Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands (Hartman, van der Meer, Hoekstra); and the Departments of Clinical Neuropsychology (Oosterlaan) and Neuropsychiatry (Heslenfeld), VU University, Amsterdam, the Netherlands
Dennis van der Meer
From the Departments of Human Genetics (Bralten, Franke, Arias-Vasquez), Cognitive Neuroscience (Bralten, Greven, Mennes, Zwiers, O’Dwyer, Buitelaar) and Psychiatry (Franke), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; the Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands (Greven, Rommelse, Buitelaar); the Institute of Psychiatry, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK (Greven); the Department of Psychiatry (Rommelse) and Genetics (Arias-Vasquez), Radboud University Medical Center, Nijmegen, the Netherlands; the Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands (Hartman, van der Meer, Hoekstra); and the Departments of Clinical Neuropsychology (Oosterlaan) and Neuropsychiatry (Heslenfeld), VU University, Amsterdam, the Netherlands
Laurence O’Dwyer
From the Departments of Human Genetics (Bralten, Franke, Arias-Vasquez), Cognitive Neuroscience (Bralten, Greven, Mennes, Zwiers, O’Dwyer, Buitelaar) and Psychiatry (Franke), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; the Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands (Greven, Rommelse, Buitelaar); the Institute of Psychiatry, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK (Greven); the Department of Psychiatry (Rommelse) and Genetics (Arias-Vasquez), Radboud University Medical Center, Nijmegen, the Netherlands; the Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands (Hartman, van der Meer, Hoekstra); and the Departments of Clinical Neuropsychology (Oosterlaan) and Neuropsychiatry (Heslenfeld), VU University, Amsterdam, the Netherlands
Jaap Oosterlaan
From the Departments of Human Genetics (Bralten, Franke, Arias-Vasquez), Cognitive Neuroscience (Bralten, Greven, Mennes, Zwiers, O’Dwyer, Buitelaar) and Psychiatry (Franke), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; the Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands (Greven, Rommelse, Buitelaar); the Institute of Psychiatry, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK (Greven); the Department of Psychiatry (Rommelse) and Genetics (Arias-Vasquez), Radboud University Medical Center, Nijmegen, the Netherlands; the Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands (Hartman, van der Meer, Hoekstra); and the Departments of Clinical Neuropsychology (Oosterlaan) and Neuropsychiatry (Heslenfeld), VU University, Amsterdam, the Netherlands
Pieter J. Hoekstra
From the Departments of Human Genetics (Bralten, Franke, Arias-Vasquez), Cognitive Neuroscience (Bralten, Greven, Mennes, Zwiers, O’Dwyer, Buitelaar) and Psychiatry (Franke), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; the Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands (Greven, Rommelse, Buitelaar); the Institute of Psychiatry, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK (Greven); the Department of Psychiatry (Rommelse) and Genetics (Arias-Vasquez), Radboud University Medical Center, Nijmegen, the Netherlands; the Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands (Hartman, van der Meer, Hoekstra); and the Departments of Clinical Neuropsychology (Oosterlaan) and Neuropsychiatry (Heslenfeld), VU University, Amsterdam, the Netherlands
Dirk Heslenfeld
From the Departments of Human Genetics (Bralten, Franke, Arias-Vasquez), Cognitive Neuroscience (Bralten, Greven, Mennes, Zwiers, O’Dwyer, Buitelaar) and Psychiatry (Franke), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; the Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands (Greven, Rommelse, Buitelaar); the Institute of Psychiatry, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK (Greven); the Department of Psychiatry (Rommelse) and Genetics (Arias-Vasquez), Radboud University Medical Center, Nijmegen, the Netherlands; the Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands (Hartman, van der Meer, Hoekstra); and the Departments of Clinical Neuropsychology (Oosterlaan) and Neuropsychiatry (Heslenfeld), VU University, Amsterdam, the Netherlands
Alejandro Arias-Vasquez
From the Departments of Human Genetics (Bralten, Franke, Arias-Vasquez), Cognitive Neuroscience (Bralten, Greven, Mennes, Zwiers, O’Dwyer, Buitelaar) and Psychiatry (Franke), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; the Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands (Greven, Rommelse, Buitelaar); the Institute of Psychiatry, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK (Greven); the Department of Psychiatry (Rommelse) and Genetics (Arias-Vasquez), Radboud University Medical Center, Nijmegen, the Netherlands; the Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands (Hartman, van der Meer, Hoekstra); and the Departments of Clinical Neuropsychology (Oosterlaan) and Neuropsychiatry (Heslenfeld), VU University, Amsterdam, the Netherlands
Jan K. Buitelaar
From the Departments of Human Genetics (Bralten, Franke, Arias-Vasquez), Cognitive Neuroscience (Bralten, Greven, Mennes, Zwiers, O’Dwyer, Buitelaar) and Psychiatry (Franke), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; the Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands (Greven, Rommelse, Buitelaar); the Institute of Psychiatry, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK (Greven); the Department of Psychiatry (Rommelse) and Genetics (Arias-Vasquez), Radboud University Medical Center, Nijmegen, the Netherlands; the Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands (Hartman, van der Meer, Hoekstra); and the Departments of Clinical Neuropsychology (Oosterlaan) and Neuropsychiatry (Heslenfeld), VU University, Amsterdam, the Netherlands
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Voxel-based morphometry analysis reveals frontal brain differences in participants with ADHD and their unaffected siblings
Janita Bralten, Corina U. Greven, Barbara Franke, Maarten Mennes, Marcel P. Zwiers, Nanda N.J. Rommelse, Catharina Hartman, Dennis van der Meer, Laurence O’Dwyer, Jaap Oosterlaan, Pieter J. Hoekstra, Dirk Heslenfeld, Alejandro Arias-Vasquez, Jan K. Buitelaar
J Psychiatry Neurosci Jul 2016, 41 (4) 272-279; DOI: 10.1503/jpn.140377
Voxel-based morphometry analysis reveals frontal brain differences in participants with ADHD and their unaffected siblings
Janita Bralten, Corina U. Greven, Barbara Franke, Maarten Mennes, Marcel P. Zwiers, Nanda N.J. Rommelse, Catharina Hartman, Dennis van der Meer, Laurence O’Dwyer, Jaap Oosterlaan, Pieter J. Hoekstra, Dirk Heslenfeld, Alejandro Arias-Vasquez, Jan K. Buitelaar
J Psychiatry Neurosci Jul 2016, 41 (4) 272-279; DOI: 10.1503/jpn.140377
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