Research Paper
Voxel-based morphometry analysis reveals frontal brain differences in participants with ADHD and their unaffected siblings
Janita Bralten, Corina U. Greven, Barbara Franke, Maarten Mennes, Marcel P. Zwiers, Nanda N.J. Rommelse, Catharina Hartman, Dennis van der Meer, Laurence O’Dwyer, Jaap Oosterlaan, Pieter J. Hoekstra, Dirk Heslenfeld, Alejandro Arias-Vasquez and Jan K. Buitelaar
J Psychiatry Neurosci July 01, 2016 41 (4) 272-279; DOI: https://doi.org/10.1503/jpn.140377
Janita Bralten
From the Departments of Human Genetics (Bralten, Franke, Arias-Vasquez), Cognitive Neuroscience (Bralten, Greven, Mennes, Zwiers, O’Dwyer, Buitelaar) and Psychiatry (Franke), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; the Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands (Greven, Rommelse, Buitelaar); the Institute of Psychiatry, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK (Greven); the Department of Psychiatry (Rommelse) and Genetics (Arias-Vasquez), Radboud University Medical Center, Nijmegen, the Netherlands; the Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands (Hartman, van der Meer, Hoekstra); and the Departments of Clinical Neuropsychology (Oosterlaan) and Neuropsychiatry (Heslenfeld), VU University, Amsterdam, the Netherlands
PhDCorina U. Greven
From the Departments of Human Genetics (Bralten, Franke, Arias-Vasquez), Cognitive Neuroscience (Bralten, Greven, Mennes, Zwiers, O’Dwyer, Buitelaar) and Psychiatry (Franke), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; the Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands (Greven, Rommelse, Buitelaar); the Institute of Psychiatry, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK (Greven); the Department of Psychiatry (Rommelse) and Genetics (Arias-Vasquez), Radboud University Medical Center, Nijmegen, the Netherlands; the Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands (Hartman, van der Meer, Hoekstra); and the Departments of Clinical Neuropsychology (Oosterlaan) and Neuropsychiatry (Heslenfeld), VU University, Amsterdam, the Netherlands
PhDBarbara Franke
From the Departments of Human Genetics (Bralten, Franke, Arias-Vasquez), Cognitive Neuroscience (Bralten, Greven, Mennes, Zwiers, O’Dwyer, Buitelaar) and Psychiatry (Franke), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; the Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands (Greven, Rommelse, Buitelaar); the Institute of Psychiatry, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK (Greven); the Department of Psychiatry (Rommelse) and Genetics (Arias-Vasquez), Radboud University Medical Center, Nijmegen, the Netherlands; the Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands (Hartman, van der Meer, Hoekstra); and the Departments of Clinical Neuropsychology (Oosterlaan) and Neuropsychiatry (Heslenfeld), VU University, Amsterdam, the Netherlands
PhDMaarten Mennes
From the Departments of Human Genetics (Bralten, Franke, Arias-Vasquez), Cognitive Neuroscience (Bralten, Greven, Mennes, Zwiers, O’Dwyer, Buitelaar) and Psychiatry (Franke), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; the Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands (Greven, Rommelse, Buitelaar); the Institute of Psychiatry, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK (Greven); the Department of Psychiatry (Rommelse) and Genetics (Arias-Vasquez), Radboud University Medical Center, Nijmegen, the Netherlands; the Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands (Hartman, van der Meer, Hoekstra); and the Departments of Clinical Neuropsychology (Oosterlaan) and Neuropsychiatry (Heslenfeld), VU University, Amsterdam, the Netherlands
PhDMarcel P. Zwiers
From the Departments of Human Genetics (Bralten, Franke, Arias-Vasquez), Cognitive Neuroscience (Bralten, Greven, Mennes, Zwiers, O’Dwyer, Buitelaar) and Psychiatry (Franke), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; the Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands (Greven, Rommelse, Buitelaar); the Institute of Psychiatry, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK (Greven); the Department of Psychiatry (Rommelse) and Genetics (Arias-Vasquez), Radboud University Medical Center, Nijmegen, the Netherlands; the Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands (Hartman, van der Meer, Hoekstra); and the Departments of Clinical Neuropsychology (Oosterlaan) and Neuropsychiatry (Heslenfeld), VU University, Amsterdam, the Netherlands
PhDNanda N.J. Rommelse
From the Departments of Human Genetics (Bralten, Franke, Arias-Vasquez), Cognitive Neuroscience (Bralten, Greven, Mennes, Zwiers, O’Dwyer, Buitelaar) and Psychiatry (Franke), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; the Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands (Greven, Rommelse, Buitelaar); the Institute of Psychiatry, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK (Greven); the Department of Psychiatry (Rommelse) and Genetics (Arias-Vasquez), Radboud University Medical Center, Nijmegen, the Netherlands; the Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands (Hartman, van der Meer, Hoekstra); and the Departments of Clinical Neuropsychology (Oosterlaan) and Neuropsychiatry (Heslenfeld), VU University, Amsterdam, the Netherlands
PhDCatharina Hartman
From the Departments of Human Genetics (Bralten, Franke, Arias-Vasquez), Cognitive Neuroscience (Bralten, Greven, Mennes, Zwiers, O’Dwyer, Buitelaar) and Psychiatry (Franke), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; the Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands (Greven, Rommelse, Buitelaar); the Institute of Psychiatry, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK (Greven); the Department of Psychiatry (Rommelse) and Genetics (Arias-Vasquez), Radboud University Medical Center, Nijmegen, the Netherlands; the Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands (Hartman, van der Meer, Hoekstra); and the Departments of Clinical Neuropsychology (Oosterlaan) and Neuropsychiatry (Heslenfeld), VU University, Amsterdam, the Netherlands
PhDDennis van der Meer
From the Departments of Human Genetics (Bralten, Franke, Arias-Vasquez), Cognitive Neuroscience (Bralten, Greven, Mennes, Zwiers, O’Dwyer, Buitelaar) and Psychiatry (Franke), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; the Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands (Greven, Rommelse, Buitelaar); the Institute of Psychiatry, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK (Greven); the Department of Psychiatry (Rommelse) and Genetics (Arias-Vasquez), Radboud University Medical Center, Nijmegen, the Netherlands; the Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands (Hartman, van der Meer, Hoekstra); and the Departments of Clinical Neuropsychology (Oosterlaan) and Neuropsychiatry (Heslenfeld), VU University, Amsterdam, the Netherlands
MSLaurence O’Dwyer
From the Departments of Human Genetics (Bralten, Franke, Arias-Vasquez), Cognitive Neuroscience (Bralten, Greven, Mennes, Zwiers, O’Dwyer, Buitelaar) and Psychiatry (Franke), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; the Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands (Greven, Rommelse, Buitelaar); the Institute of Psychiatry, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK (Greven); the Department of Psychiatry (Rommelse) and Genetics (Arias-Vasquez), Radboud University Medical Center, Nijmegen, the Netherlands; the Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands (Hartman, van der Meer, Hoekstra); and the Departments of Clinical Neuropsychology (Oosterlaan) and Neuropsychiatry (Heslenfeld), VU University, Amsterdam, the Netherlands
PhDJaap Oosterlaan
From the Departments of Human Genetics (Bralten, Franke, Arias-Vasquez), Cognitive Neuroscience (Bralten, Greven, Mennes, Zwiers, O’Dwyer, Buitelaar) and Psychiatry (Franke), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; the Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands (Greven, Rommelse, Buitelaar); the Institute of Psychiatry, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK (Greven); the Department of Psychiatry (Rommelse) and Genetics (Arias-Vasquez), Radboud University Medical Center, Nijmegen, the Netherlands; the Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands (Hartman, van der Meer, Hoekstra); and the Departments of Clinical Neuropsychology (Oosterlaan) and Neuropsychiatry (Heslenfeld), VU University, Amsterdam, the Netherlands
MD, PhDPieter J. Hoekstra
From the Departments of Human Genetics (Bralten, Franke, Arias-Vasquez), Cognitive Neuroscience (Bralten, Greven, Mennes, Zwiers, O’Dwyer, Buitelaar) and Psychiatry (Franke), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; the Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands (Greven, Rommelse, Buitelaar); the Institute of Psychiatry, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK (Greven); the Department of Psychiatry (Rommelse) and Genetics (Arias-Vasquez), Radboud University Medical Center, Nijmegen, the Netherlands; the Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands (Hartman, van der Meer, Hoekstra); and the Departments of Clinical Neuropsychology (Oosterlaan) and Neuropsychiatry (Heslenfeld), VU University, Amsterdam, the Netherlands
PhDDirk Heslenfeld
From the Departments of Human Genetics (Bralten, Franke, Arias-Vasquez), Cognitive Neuroscience (Bralten, Greven, Mennes, Zwiers, O’Dwyer, Buitelaar) and Psychiatry (Franke), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; the Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands (Greven, Rommelse, Buitelaar); the Institute of Psychiatry, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK (Greven); the Department of Psychiatry (Rommelse) and Genetics (Arias-Vasquez), Radboud University Medical Center, Nijmegen, the Netherlands; the Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands (Hartman, van der Meer, Hoekstra); and the Departments of Clinical Neuropsychology (Oosterlaan) and Neuropsychiatry (Heslenfeld), VU University, Amsterdam, the Netherlands
PhDAlejandro Arias-Vasquez
From the Departments of Human Genetics (Bralten, Franke, Arias-Vasquez), Cognitive Neuroscience (Bralten, Greven, Mennes, Zwiers, O’Dwyer, Buitelaar) and Psychiatry (Franke), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; the Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands (Greven, Rommelse, Buitelaar); the Institute of Psychiatry, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK (Greven); the Department of Psychiatry (Rommelse) and Genetics (Arias-Vasquez), Radboud University Medical Center, Nijmegen, the Netherlands; the Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands (Hartman, van der Meer, Hoekstra); and the Departments of Clinical Neuropsychology (Oosterlaan) and Neuropsychiatry (Heslenfeld), VU University, Amsterdam, the Netherlands
PhDJan K. Buitelaar
From the Departments of Human Genetics (Bralten, Franke, Arias-Vasquez), Cognitive Neuroscience (Bralten, Greven, Mennes, Zwiers, O’Dwyer, Buitelaar) and Psychiatry (Franke), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; the Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands (Greven, Rommelse, Buitelaar); the Institute of Psychiatry, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK (Greven); the Department of Psychiatry (Rommelse) and Genetics (Arias-Vasquez), Radboud University Medical Center, Nijmegen, the Netherlands; the Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands (Hartman, van der Meer, Hoekstra); and the Departments of Clinical Neuropsychology (Oosterlaan) and Neuropsychiatry (Heslenfeld), VU University, Amsterdam, the Netherlands
MD, PhD
Submit a Response to This Article
Jump to comment:
No Responses have been published for this article.
In this issue
Article tools
Voxel-based morphometry analysis reveals frontal brain differences in participants with ADHD and their unaffected siblings
Janita Bralten, Corina U. Greven, Barbara Franke, Maarten Mennes, Marcel P. Zwiers, Nanda N.J. Rommelse, Catharina Hartman, Dennis van der Meer, Laurence O’Dwyer, Jaap Oosterlaan, Pieter J. Hoekstra, Dirk Heslenfeld, Alejandro Arias-Vasquez, Jan K. Buitelaar
J Psychiatry Neurosci Jul 2016, 41 (4) 272-279; DOI: 10.1503/jpn.140377
Voxel-based morphometry analysis reveals frontal brain differences in participants with ADHD and their unaffected siblings
Janita Bralten, Corina U. Greven, Barbara Franke, Maarten Mennes, Marcel P. Zwiers, Nanda N.J. Rommelse, Catharina Hartman, Dennis van der Meer, Laurence O’Dwyer, Jaap Oosterlaan, Pieter J. Hoekstra, Dirk Heslenfeld, Alejandro Arias-Vasquez, Jan K. Buitelaar
J Psychiatry Neurosci Jul 2016, 41 (4) 272-279; DOI: 10.1503/jpn.140377
Related Articles
Cited By...
- Exploring Polygenic Neuroimaging Derived Scores in a Longitudinal Attention-deficit/hyperactivity disorder Sample
- Volitional brain regulation is related to improvements in affective characteristics of adolescents with autism spectrum disorder
- Gray matter networks associated with cognitive deficit in ADHD across adolescence and adulthood
- Structural Brain Alterations and Their Association with Cognitive Function and Symptoms in Attention-Deficit/Hyperactivity Disorder Families
- Reduced fronto-striatal volume in ADHD in two cohorts across the lifespan
- Genetic markers of ADHD-related variations in intracranial volume