Dysfunctional insular connectivity during reward prediction in patients with first-episode psychosis

From the Department of Psychiatry (UPK), University of Basel, Switzerland (Schmidt, Smieskova, Simon, Rössler, Lang, Borgwardt); the Institute of Psychiatry, Department of Psychosis Studies, King’s College London, UK (Schmidt, Fusar-Poli, McGuire, Borgwardt); the Medical Image Analysis Center (MIAC), University Hospital Basel, Switzerland (Schmidt, Smieskova, Borgwardt); the Departments of Psychiatry and Medical Biophysics, Western Univeristy, London, Ont., Canada (Palaniyappan); and the Division of Psychiatry, University of Nottingham, UK (Palaniyappan)

From the Department of Psychiatry (UPK), University of Basel, Switzerland (Schmidt, Smieskova, Simon, Rössler, Lang, Borgwardt); the Institute of Psychiatry, Department of Psychosis Studies, King’s College London, UK (Schmidt, Fusar-Poli, McGuire, Borgwardt); the Medical Image Analysis Center (MIAC), University Hospital Basel, Switzerland (Schmidt, Smieskova, Borgwardt); the Departments of Psychiatry and Medical Biophysics, Western Univeristy, London, Ont., Canada (Palaniyappan); and the Division of Psychiatry, University of Nottingham, UK (Palaniyappan)

From the Department of Psychiatry (UPK), University of Basel, Switzerland (Schmidt, Smieskova, Simon, Rössler, Lang, Borgwardt); the Institute of Psychiatry, Department of Psychosis Studies, King’s College London, UK (Schmidt, Fusar-Poli, McGuire, Borgwardt); the Medical Image Analysis Center (MIAC), University Hospital Basel, Switzerland (Schmidt, Smieskova, Borgwardt); the Departments of Psychiatry and Medical Biophysics, Western Univeristy, London, Ont., Canada (Palaniyappan); and the Division of Psychiatry, University of Nottingham, UK (Palaniyappan)

From the Department of Psychiatry (UPK), University of Basel, Switzerland (Schmidt, Smieskova, Simon, Rössler, Lang, Borgwardt); the Institute of Psychiatry, Department of Psychosis Studies, King’s College London, UK (Schmidt, Fusar-Poli, McGuire, Borgwardt); the Medical Image Analysis Center (MIAC), University Hospital Basel, Switzerland (Schmidt, Smieskova, Borgwardt); the Departments of Psychiatry and Medical Biophysics, Western Univeristy, London, Ont., Canada (Palaniyappan); and the Division of Psychiatry, University of Nottingham, UK (Palaniyappan)

From the Department of Psychiatry (UPK), University of Basel, Switzerland (Schmidt, Smieskova, Simon, Rössler, Lang, Borgwardt); the Institute of Psychiatry, Department of Psychosis Studies, King’s College London, UK (Schmidt, Fusar-Poli, McGuire, Borgwardt); the Medical Image Analysis Center (MIAC), University Hospital Basel, Switzerland (Schmidt, Smieskova, Borgwardt); the Departments of Psychiatry and Medical Biophysics, Western Univeristy, London, Ont., Canada (Palaniyappan); and the Division of Psychiatry, University of Nottingham, UK (Palaniyappan)

From the Department of Psychiatry (UPK), University of Basel, Switzerland (Schmidt, Smieskova, Simon, Rössler, Lang, Borgwardt); the Institute of Psychiatry, Department of Psychosis Studies, King’s College London, UK (Schmidt, Fusar-Poli, McGuire, Borgwardt); the Medical Image Analysis Center (MIAC), University Hospital Basel, Switzerland (Schmidt, Smieskova, Borgwardt); the Departments of Psychiatry and Medical Biophysics, Western Univeristy, London, Ont., Canada (Palaniyappan); and the Division of Psychiatry, University of Nottingham, UK (Palaniyappan)

From the Department of Psychiatry (UPK), University of Basel, Switzerland (Schmidt, Smieskova, Simon, Rössler, Lang, Borgwardt); the Institute of Psychiatry, Department of Psychosis Studies, King’s College London, UK (Schmidt, Fusar-Poli, McGuire, Borgwardt); the Medical Image Analysis Center (MIAC), University Hospital Basel, Switzerland (Schmidt, Smieskova, Borgwardt); the Departments of Psychiatry and Medical Biophysics, Western Univeristy, London, Ont., Canada (Palaniyappan); and the Division of Psychiatry, University of Nottingham, UK (Palaniyappan)

From the Department of Psychiatry (UPK), University of Basel, Switzerland (Schmidt, Smieskova, Simon, Rössler, Lang, Borgwardt); the Institute of Psychiatry, Department of Psychosis Studies, King’s College London, UK (Schmidt, Fusar-Poli, McGuire, Borgwardt); the Medical Image Analysis Center (MIAC), University Hospital Basel, Switzerland (Schmidt, Smieskova, Borgwardt); the Departments of Psychiatry and Medical Biophysics, Western Univeristy, London, Ont., Canada (Palaniyappan); and the Division of Psychiatry, University of Nottingham, UK (Palaniyappan)

From the Department of Psychiatry (UPK), University of Basel, Switzerland (Schmidt, Smieskova, Simon, Rössler, Lang, Borgwardt); the Institute of Psychiatry, Department of Psychosis Studies, King’s College London, UK (Schmidt, Fusar-Poli, McGuire, Borgwardt); the Medical Image Analysis Center (MIAC), University Hospital Basel, Switzerland (Schmidt, Smieskova, Borgwardt); the Departments of Psychiatry and Medical Biophysics, Western Univeristy, London, Ont., Canada (Palaniyappan); and the Division of Psychiatry, University of Nottingham, UK (Palaniyappan)