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Figures
- Fig. 1
(A–D) Rat cognitive effort task (rCET) performance following systemic administration of cannabinoid agents. The CB1 and CB2 receptor antagonists rimonabant and AM630 did not affect choice, accuracy, or premature responding. (E–F) Similarly, the FAAH inhibitor URB 597 did not affect rCET performance. (G–H) Although WIN 55, 212–2 increased premature responding for low-effort/low-reward (LR) trials across both groups (Appendix 1, Fig. S2D), this synthetic CB1 receptor agonist did not affect measures of choice or accuracy. Data are expressed as the mean (± standard error of the mean) percent for each variable. HR = high-effort/high-reward.
- Fig. 2
(A–B) Rat cognitive effort task (rCET) performance following systemic administration of cannabinoids found in cannabis. At all doses, Δ9-tetrahydrocannabinol (THC) decreased selection of high-effort/high-reward (HR) trials in workers and slackers without affecting attentional ability or impulsivity. (C–D) Cannabidiol (CBD) did not affect rCET behaviour in isolation, (E) but partially attenuated THC-induced choice impairments in slacker rats when coadministered at a 1:1 THC:CBD ratio (V-V = 0–0 mg/kg, V-THC = 0–2.0 mg/kg, 10:1 THC:CBD = 2.0/0.2 mg/kg, 1:1 THC:CBD = 2.0/2.0 mg/kg). (E–F) The data are from a subset of the original cohort (top 9 workers and slackers, respectively), and as such the choice profiles at vehicle are more divergent. (F) Given the top workers rarely chose the low-effort/low-reward (LR) option, accuracy could not be calculated and for this reason is not displayed. Data are expressed as the mean (± standard error of the mean) percent for each variable. *p < 0.05; #p < 0.10.
- Fig. 3
CB1 receptor density in the medial prefrontal cortex (mPFC) is correlated with Δ9-tetrahydrocannabinol (THC)-induced choice impairments. The “average change” measure was derived by calculating the percent change in choice of the high-effort/high-reward (HR) option at each THC dose relative to vehicle, and then averaging across the doses to develop a general measure of THC sensitivity for each rat.
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