Research Paper
Basolateral amygdala–ventromedial prefrontal cortex connectivity predicts cognitive behavioural therapy outcome in adults with obsessive–compulsive disorder
Miquel A. Fullana, Xi Zhu, Pino Alonso, Narcís Cardoner, Eva Real, Clara López-Solà, Cinto Segalàs, Marta Subirà, Hanga Galfalvy, José M. Menchón, H. Blair Simpson, Rachel Marsh and Carles Soriano-Mas
J Psychiatry Neurosci November 01, 2017 42 (6) 378-385; DOI: https://doi.org/10.1503/jpn.160215
Miquel A. Fullana
From the Institut de Neuropsiquiatria i Addiccions, Hospital del Mar, Barcelona and IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Fullana); CIBERSAM, Instituto de Salud Carlos III, Spain (Fullana, Alonso, Cardoner, Real, López-Solà, Segalàs, Subirà, Menchón, Soriano-Mas); the Department of Psychiatry, Autonomous University of Barcelona, Spain (Fullana, Cardoner); the Department of Psychiatry, Columbia University Medical Center, New York, NY, USA, and Division of Clinical Therapeutics, New York State Psychiatric Institute, New York, NY, USA (Fullana, Zhu, Simpson); the Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain (Alonso, Real, Segalàs, Subirà, Menchón, Soriano-Mas); the Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain (Alonso, Menchón); the Depression and Anxiety Unit, Mental Health Department, Parc Taulí Sabadell University Hospital, Barcelona, Spain (Cardoner, López-Solà); the New York State Psychiatric Institute, New York, NY, USA, and Columbia Psychiatry, Columbia University, New York, NY, USA (Galfalvy); the Division of Child and Adolescent Psychiatry, Department of Psychiatry, New York State Psychiatric Institute and College of Physicians and Surgeons, Columbia University, New York, NY, USA (Marsh); and the Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, Spain (Soriano-Mas).
PhDXi Zhu
From the Institut de Neuropsiquiatria i Addiccions, Hospital del Mar, Barcelona and IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Fullana); CIBERSAM, Instituto de Salud Carlos III, Spain (Fullana, Alonso, Cardoner, Real, López-Solà, Segalàs, Subirà, Menchón, Soriano-Mas); the Department of Psychiatry, Autonomous University of Barcelona, Spain (Fullana, Cardoner); the Department of Psychiatry, Columbia University Medical Center, New York, NY, USA, and Division of Clinical Therapeutics, New York State Psychiatric Institute, New York, NY, USA (Fullana, Zhu, Simpson); the Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain (Alonso, Real, Segalàs, Subirà, Menchón, Soriano-Mas); the Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain (Alonso, Menchón); the Depression and Anxiety Unit, Mental Health Department, Parc Taulí Sabadell University Hospital, Barcelona, Spain (Cardoner, López-Solà); the New York State Psychiatric Institute, New York, NY, USA, and Columbia Psychiatry, Columbia University, New York, NY, USA (Galfalvy); the Division of Child and Adolescent Psychiatry, Department of Psychiatry, New York State Psychiatric Institute and College of Physicians and Surgeons, Columbia University, New York, NY, USA (Marsh); and the Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, Spain (Soriano-Mas).
PhDPino Alonso
From the Institut de Neuropsiquiatria i Addiccions, Hospital del Mar, Barcelona and IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Fullana); CIBERSAM, Instituto de Salud Carlos III, Spain (Fullana, Alonso, Cardoner, Real, López-Solà, Segalàs, Subirà, Menchón, Soriano-Mas); the Department of Psychiatry, Autonomous University of Barcelona, Spain (Fullana, Cardoner); the Department of Psychiatry, Columbia University Medical Center, New York, NY, USA, and Division of Clinical Therapeutics, New York State Psychiatric Institute, New York, NY, USA (Fullana, Zhu, Simpson); the Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain (Alonso, Real, Segalàs, Subirà, Menchón, Soriano-Mas); the Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain (Alonso, Menchón); the Depression and Anxiety Unit, Mental Health Department, Parc Taulí Sabadell University Hospital, Barcelona, Spain (Cardoner, López-Solà); the New York State Psychiatric Institute, New York, NY, USA, and Columbia Psychiatry, Columbia University, New York, NY, USA (Galfalvy); the Division of Child and Adolescent Psychiatry, Department of Psychiatry, New York State Psychiatric Institute and College of Physicians and Surgeons, Columbia University, New York, NY, USA (Marsh); and the Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, Spain (Soriano-Mas).
MD, PhDNarcís Cardoner
From the Institut de Neuropsiquiatria i Addiccions, Hospital del Mar, Barcelona and IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Fullana); CIBERSAM, Instituto de Salud Carlos III, Spain (Fullana, Alonso, Cardoner, Real, López-Solà, Segalàs, Subirà, Menchón, Soriano-Mas); the Department of Psychiatry, Autonomous University of Barcelona, Spain (Fullana, Cardoner); the Department of Psychiatry, Columbia University Medical Center, New York, NY, USA, and Division of Clinical Therapeutics, New York State Psychiatric Institute, New York, NY, USA (Fullana, Zhu, Simpson); the Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain (Alonso, Real, Segalàs, Subirà, Menchón, Soriano-Mas); the Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain (Alonso, Menchón); the Depression and Anxiety Unit, Mental Health Department, Parc Taulí Sabadell University Hospital, Barcelona, Spain (Cardoner, López-Solà); the New York State Psychiatric Institute, New York, NY, USA, and Columbia Psychiatry, Columbia University, New York, NY, USA (Galfalvy); the Division of Child and Adolescent Psychiatry, Department of Psychiatry, New York State Psychiatric Institute and College of Physicians and Surgeons, Columbia University, New York, NY, USA (Marsh); and the Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, Spain (Soriano-Mas).
MD, PhDEva Real
From the Institut de Neuropsiquiatria i Addiccions, Hospital del Mar, Barcelona and IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Fullana); CIBERSAM, Instituto de Salud Carlos III, Spain (Fullana, Alonso, Cardoner, Real, López-Solà, Segalàs, Subirà, Menchón, Soriano-Mas); the Department of Psychiatry, Autonomous University of Barcelona, Spain (Fullana, Cardoner); the Department of Psychiatry, Columbia University Medical Center, New York, NY, USA, and Division of Clinical Therapeutics, New York State Psychiatric Institute, New York, NY, USA (Fullana, Zhu, Simpson); the Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain (Alonso, Real, Segalàs, Subirà, Menchón, Soriano-Mas); the Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain (Alonso, Menchón); the Depression and Anxiety Unit, Mental Health Department, Parc Taulí Sabadell University Hospital, Barcelona, Spain (Cardoner, López-Solà); the New York State Psychiatric Institute, New York, NY, USA, and Columbia Psychiatry, Columbia University, New York, NY, USA (Galfalvy); the Division of Child and Adolescent Psychiatry, Department of Psychiatry, New York State Psychiatric Institute and College of Physicians and Surgeons, Columbia University, New York, NY, USA (Marsh); and the Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, Spain (Soriano-Mas).
MD, PhDClara López-Solà
From the Institut de Neuropsiquiatria i Addiccions, Hospital del Mar, Barcelona and IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Fullana); CIBERSAM, Instituto de Salud Carlos III, Spain (Fullana, Alonso, Cardoner, Real, López-Solà, Segalàs, Subirà, Menchón, Soriano-Mas); the Department of Psychiatry, Autonomous University of Barcelona, Spain (Fullana, Cardoner); the Department of Psychiatry, Columbia University Medical Center, New York, NY, USA, and Division of Clinical Therapeutics, New York State Psychiatric Institute, New York, NY, USA (Fullana, Zhu, Simpson); the Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain (Alonso, Real, Segalàs, Subirà, Menchón, Soriano-Mas); the Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain (Alonso, Menchón); the Depression and Anxiety Unit, Mental Health Department, Parc Taulí Sabadell University Hospital, Barcelona, Spain (Cardoner, López-Solà); the New York State Psychiatric Institute, New York, NY, USA, and Columbia Psychiatry, Columbia University, New York, NY, USA (Galfalvy); the Division of Child and Adolescent Psychiatry, Department of Psychiatry, New York State Psychiatric Institute and College of Physicians and Surgeons, Columbia University, New York, NY, USA (Marsh); and the Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, Spain (Soriano-Mas).
PhDCinto Segalàs
From the Institut de Neuropsiquiatria i Addiccions, Hospital del Mar, Barcelona and IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Fullana); CIBERSAM, Instituto de Salud Carlos III, Spain (Fullana, Alonso, Cardoner, Real, López-Solà, Segalàs, Subirà, Menchón, Soriano-Mas); the Department of Psychiatry, Autonomous University of Barcelona, Spain (Fullana, Cardoner); the Department of Psychiatry, Columbia University Medical Center, New York, NY, USA, and Division of Clinical Therapeutics, New York State Psychiatric Institute, New York, NY, USA (Fullana, Zhu, Simpson); the Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain (Alonso, Real, Segalàs, Subirà, Menchón, Soriano-Mas); the Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain (Alonso, Menchón); the Depression and Anxiety Unit, Mental Health Department, Parc Taulí Sabadell University Hospital, Barcelona, Spain (Cardoner, López-Solà); the New York State Psychiatric Institute, New York, NY, USA, and Columbia Psychiatry, Columbia University, New York, NY, USA (Galfalvy); the Division of Child and Adolescent Psychiatry, Department of Psychiatry, New York State Psychiatric Institute and College of Physicians and Surgeons, Columbia University, New York, NY, USA (Marsh); and the Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, Spain (Soriano-Mas).
MD, PhDMarta Subirà
From the Institut de Neuropsiquiatria i Addiccions, Hospital del Mar, Barcelona and IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Fullana); CIBERSAM, Instituto de Salud Carlos III, Spain (Fullana, Alonso, Cardoner, Real, López-Solà, Segalàs, Subirà, Menchón, Soriano-Mas); the Department of Psychiatry, Autonomous University of Barcelona, Spain (Fullana, Cardoner); the Department of Psychiatry, Columbia University Medical Center, New York, NY, USA, and Division of Clinical Therapeutics, New York State Psychiatric Institute, New York, NY, USA (Fullana, Zhu, Simpson); the Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain (Alonso, Real, Segalàs, Subirà, Menchón, Soriano-Mas); the Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain (Alonso, Menchón); the Depression and Anxiety Unit, Mental Health Department, Parc Taulí Sabadell University Hospital, Barcelona, Spain (Cardoner, López-Solà); the New York State Psychiatric Institute, New York, NY, USA, and Columbia Psychiatry, Columbia University, New York, NY, USA (Galfalvy); the Division of Child and Adolescent Psychiatry, Department of Psychiatry, New York State Psychiatric Institute and College of Physicians and Surgeons, Columbia University, New York, NY, USA (Marsh); and the Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, Spain (Soriano-Mas).
MD, PhDHanga Galfalvy
From the Institut de Neuropsiquiatria i Addiccions, Hospital del Mar, Barcelona and IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Fullana); CIBERSAM, Instituto de Salud Carlos III, Spain (Fullana, Alonso, Cardoner, Real, López-Solà, Segalàs, Subirà, Menchón, Soriano-Mas); the Department of Psychiatry, Autonomous University of Barcelona, Spain (Fullana, Cardoner); the Department of Psychiatry, Columbia University Medical Center, New York, NY, USA, and Division of Clinical Therapeutics, New York State Psychiatric Institute, New York, NY, USA (Fullana, Zhu, Simpson); the Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain (Alonso, Real, Segalàs, Subirà, Menchón, Soriano-Mas); the Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain (Alonso, Menchón); the Depression and Anxiety Unit, Mental Health Department, Parc Taulí Sabadell University Hospital, Barcelona, Spain (Cardoner, López-Solà); the New York State Psychiatric Institute, New York, NY, USA, and Columbia Psychiatry, Columbia University, New York, NY, USA (Galfalvy); the Division of Child and Adolescent Psychiatry, Department of Psychiatry, New York State Psychiatric Institute and College of Physicians and Surgeons, Columbia University, New York, NY, USA (Marsh); and the Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, Spain (Soriano-Mas).
PhDJosé M. Menchón
From the Institut de Neuropsiquiatria i Addiccions, Hospital del Mar, Barcelona and IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Fullana); CIBERSAM, Instituto de Salud Carlos III, Spain (Fullana, Alonso, Cardoner, Real, López-Solà, Segalàs, Subirà, Menchón, Soriano-Mas); the Department of Psychiatry, Autonomous University of Barcelona, Spain (Fullana, Cardoner); the Department of Psychiatry, Columbia University Medical Center, New York, NY, USA, and Division of Clinical Therapeutics, New York State Psychiatric Institute, New York, NY, USA (Fullana, Zhu, Simpson); the Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain (Alonso, Real, Segalàs, Subirà, Menchón, Soriano-Mas); the Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain (Alonso, Menchón); the Depression and Anxiety Unit, Mental Health Department, Parc Taulí Sabadell University Hospital, Barcelona, Spain (Cardoner, López-Solà); the New York State Psychiatric Institute, New York, NY, USA, and Columbia Psychiatry, Columbia University, New York, NY, USA (Galfalvy); the Division of Child and Adolescent Psychiatry, Department of Psychiatry, New York State Psychiatric Institute and College of Physicians and Surgeons, Columbia University, New York, NY, USA (Marsh); and the Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, Spain (Soriano-Mas).
MD, PhDH. Blair Simpson
From the Institut de Neuropsiquiatria i Addiccions, Hospital del Mar, Barcelona and IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Fullana); CIBERSAM, Instituto de Salud Carlos III, Spain (Fullana, Alonso, Cardoner, Real, López-Solà, Segalàs, Subirà, Menchón, Soriano-Mas); the Department of Psychiatry, Autonomous University of Barcelona, Spain (Fullana, Cardoner); the Department of Psychiatry, Columbia University Medical Center, New York, NY, USA, and Division of Clinical Therapeutics, New York State Psychiatric Institute, New York, NY, USA (Fullana, Zhu, Simpson); the Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain (Alonso, Real, Segalàs, Subirà, Menchón, Soriano-Mas); the Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain (Alonso, Menchón); the Depression and Anxiety Unit, Mental Health Department, Parc Taulí Sabadell University Hospital, Barcelona, Spain (Cardoner, López-Solà); the New York State Psychiatric Institute, New York, NY, USA, and Columbia Psychiatry, Columbia University, New York, NY, USA (Galfalvy); the Division of Child and Adolescent Psychiatry, Department of Psychiatry, New York State Psychiatric Institute and College of Physicians and Surgeons, Columbia University, New York, NY, USA (Marsh); and the Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, Spain (Soriano-Mas).
MD, PhDRachel Marsh
From the Institut de Neuropsiquiatria i Addiccions, Hospital del Mar, Barcelona and IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Fullana); CIBERSAM, Instituto de Salud Carlos III, Spain (Fullana, Alonso, Cardoner, Real, López-Solà, Segalàs, Subirà, Menchón, Soriano-Mas); the Department of Psychiatry, Autonomous University of Barcelona, Spain (Fullana, Cardoner); the Department of Psychiatry, Columbia University Medical Center, New York, NY, USA, and Division of Clinical Therapeutics, New York State Psychiatric Institute, New York, NY, USA (Fullana, Zhu, Simpson); the Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain (Alonso, Real, Segalàs, Subirà, Menchón, Soriano-Mas); the Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain (Alonso, Menchón); the Depression and Anxiety Unit, Mental Health Department, Parc Taulí Sabadell University Hospital, Barcelona, Spain (Cardoner, López-Solà); the New York State Psychiatric Institute, New York, NY, USA, and Columbia Psychiatry, Columbia University, New York, NY, USA (Galfalvy); the Division of Child and Adolescent Psychiatry, Department of Psychiatry, New York State Psychiatric Institute and College of Physicians and Surgeons, Columbia University, New York, NY, USA (Marsh); and the Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, Spain (Soriano-Mas).
PhDCarles Soriano-Mas
From the Institut de Neuropsiquiatria i Addiccions, Hospital del Mar, Barcelona and IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Fullana); CIBERSAM, Instituto de Salud Carlos III, Spain (Fullana, Alonso, Cardoner, Real, López-Solà, Segalàs, Subirà, Menchón, Soriano-Mas); the Department of Psychiatry, Autonomous University of Barcelona, Spain (Fullana, Cardoner); the Department of Psychiatry, Columbia University Medical Center, New York, NY, USA, and Division of Clinical Therapeutics, New York State Psychiatric Institute, New York, NY, USA (Fullana, Zhu, Simpson); the Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain (Alonso, Real, Segalàs, Subirà, Menchón, Soriano-Mas); the Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain (Alonso, Menchón); the Depression and Anxiety Unit, Mental Health Department, Parc Taulí Sabadell University Hospital, Barcelona, Spain (Cardoner, López-Solà); the New York State Psychiatric Institute, New York, NY, USA, and Columbia Psychiatry, Columbia University, New York, NY, USA (Galfalvy); the Division of Child and Adolescent Psychiatry, Department of Psychiatry, New York State Psychiatric Institute and College of Physicians and Surgeons, Columbia University, New York, NY, USA (Marsh); and the Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, Spain (Soriano-Mas).
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Basolateral amygdala–ventromedial prefrontal cortex connectivity predicts cognitive behavioural therapy outcome in adults with obsessive–compulsive disorder
Miquel A. Fullana, Xi Zhu, Pino Alonso, Narcís Cardoner, Eva Real, Clara López-Solà, Cinto Segalàs, Marta Subirà, Hanga Galfalvy, José M. Menchón, H. Blair Simpson, Rachel Marsh, Carles Soriano-Mas
J Psychiatry Neurosci Nov 2017, 42 (6) 378-385; DOI: 10.1503/jpn.160215
Basolateral amygdala–ventromedial prefrontal cortex connectivity predicts cognitive behavioural therapy outcome in adults with obsessive–compulsive disorder
Miquel A. Fullana, Xi Zhu, Pino Alonso, Narcís Cardoner, Eva Real, Clara López-Solà, Cinto Segalàs, Marta Subirà, Hanga Galfalvy, José M. Menchón, H. Blair Simpson, Rachel Marsh, Carles Soriano-Mas
J Psychiatry Neurosci Nov 2017, 42 (6) 378-385; DOI: 10.1503/jpn.160215
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