Affect, interpersonal behaviour and interpersonal perception during open-label, uncontrolled paroxetine treatment of people with social anxiety disorder: a pilot study

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Fig. 1
Changes in symptom severity (A, B) and event-level affect mean and variability (C, D). LSAS = Liebowitz Social Anxiety Scale; MADRS = Montgomery–Åsberg Depression Rating Scale; SIAS = Social Interaction and Anxiety Scale; SPS = Social Phobia Scale.
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Fig. 2
Changes in mean and variability of participants’ perception of others’ behaviour (A, B) and participants’ own interpersonal behaviour (C, D).

Table 1

Change in anxiety and depression symptom severity over treatment

Scale	Intercept, B (95% CI)	Linear slope, B (95% CI)	Quadratic slope, B (95% CI)
Liebowitz Social Anxiety Scale	116.38^*** (106.31 to 126.45)	−35.52^*** (−43.06 to −27.97)	4.03^*** (2.81 to 5.25)
Social Phobia Scale	61.85^*** (55.65 to 68.05)	−18.26^*** (−22.19 to −14.33)	2.01^*** (1.39 to 2.63)
Social Interaction and Anxiety Scale	63.96^*** (59.16 to 68.76)	−17.67^*** (−21.34 to −14.01)	1.92^*** (1.34 to 2.50)
Montgomery–Åsberg Depression Rating Scale	9.74^*** (6.91 to 12.57)	−3.07^** (−5.25 to −0.89)	0.34 (−0.02 to 0.70)

CI = confidence interval.
↵** p ≤ 0.01;
↵*** p ≤ 0.001.
For random-effect estimates, see Appendix 1, Table S1, available at jpn.ca/170141-a1.

Table 2

Change in affect, perception and interpersonal behaviour over treatment, mean (location) and variance (scale)

	Mean				Variance

Measure	Intercept, B/σ² (95% CI)	Linear slope, B/σ² (95% CI)	Quadratic slope, B/σ² (95% CI)	Cubic slope, B/σ² (95% CI)	Intercept, B/σ² (95% CI)	Linear slope, B/σ² (95% CI)
Positive affect	2.21^*** (1.89 to 2.52)	0.47^*** (0.29 to 0.65)	−0.08^*** (−0.13 to −0.04)	—	0.18 (−0.01 to 0.37)	−0.15^*** (−0.19 to −0.11)
Negative affect	1.32^*** (1.12 to 1.51)	−0.51^*** (−0.62 to −0.39)	0.08^*** (0.06 to 0.11)	—	−0.18 (−0.49 to 0.13)	−0.47^*** (−0.51 to −0.44)
Perception of warmth	7.39^*** (7.02 to 7.75)	0.67^*** (0.41 to 0.93)	−0.10^** (−0.16 to −0.04)	—	1.76^*** (1.56 to 1.97)	−0.18^*** (−0.22 to −0.14)
Perception of dominance	7.63^*** (7.37 to 7.88)	—	—	—	1.56^*** (1.36 to 1.77)	−0.23^*** (−0.27 to −0.19)
Agreeable behaviour	11.83^*** (9.36 to 14.29)	5.22^*** (2.94 to 7.51)	−1.06^*** (−1.62 to −0.50)	—	6.30^*** (6.22 to 6.39)	−0.05^** (−0.08 to −0.01)
Quarrelsome behaviour	−15.21^*** (−17.58 to −12.83)	−1.82^* (−3.47 to −0.17)	0.40^* (−0.003 to 0.81)	—	6.00^*** (5.84 to 6.16)	−0.09^*** (−0.13 to −0.06)
Dominant behaviour	−0.88 (−3.68 to 1.92)	2.21^*** (1.27 to 3.15)	—	—	6.30^*** (6.20 to 6.39)	−0.06^** (−0.09 to −0.02)
Submissive behaviour	3.83^* (0.47 to 7.18)	−14.28^*** (−20.05 to −8.51)	6.18^** (2.45 to 9.91)	−0.88^** (−1.50 to −0.25)	6.52^*** (6.41 to 6.64)	−0.15^*** (−0.19 to −0.12)

CI = confidence interval.
↵* p ≤ 0.05;
↵** p ≤ 0.01;
↵*** p ≤ 0.001.
Dashes indicate a nonsignificant effect not included in the final model.
For random-effect estimates, see Appendix 1, Table S2 and Table S3, available at jpn.ca/170141-a1.