Article Figures & Tables
Figures
- Fig. 1
Motor cortical excitability between patients with OCD and healthy controls. Graph showing variable means of bilateral RMT, CSP, ICF and SICI amplitudes in patients with OCD (n = 51) and controls (n = 39). Error bars represent ± 1 standard error of the mean. CSP = cortical silent period; ICF = intracortical facilitation; MEP = motor evoked potential; OCD = obsessive–compulsive disorder; RMT = resting motor threshold; SICI = short-interval intracortical inhibition.
- Fig. 2
Correlation between CSP and mean reaction time for the correct go trials in the go/no-go task and age at onset in patients with OCD (n = 51). CSP = cortical silent period; OCD = obsessive–compulsive disorder.
Tables
- Table 1
Demographic and clinical characteristics between patients with OCD and healthy controls*
Characteristic Healthy controls (n = 39) OCD (n = 51) t or χ2 p value M/F, n 30/9 40/11 0.029 0.87 Education, yr 14.10 ± 2.00 13.41 ± 2.19 −1.54 0.13 MOCI score 4.61 ± 2.67 17.49 ± 5.90 13.85 < 0.001 Age of OCD onset, yr — 15.90 ± 5.80 — — Y-BOCS score — 23.51 ± 7.23 — — MADRS score — 16.94 ± 10.02 — — HARS score — 14.45 ± 9.95 — — Comorbid depression, n 0 21 — — Receiving SRIs, n 0 51† — — Concomitant medications Benzodiazepines, n 0 28‡ — — Antipsychotics, n 0 4§ — — Go/no-go task Successful inhibition trials, % — 84.51 ± 9.76 — — Reaction time for go trials, ms — 300.84 ± 49.75 — — HARS = Hamilton Anxiety Rating Scale; MADRS = Montgomery–Åsberg Depression Rating Scale; MOCI = Maudsley Obsessional Compulsive Inventory; OCD = obsessive–compulsive disorder; SRI = serotonin reuptake inhibitor; Y-BOCS = Yale–Brown Obsessive Compulsive Scale.
↵* Data shown as mean ± standard deviation unless otherwise specified. All tests were 2-tailed.
↵† Escitalopram 10~40 mg/d: 16; fluoxetine 40~100 mg/d: 15; paroxetine 37.5~87.5 mg/d: 9; sertraline 100~200 mg/d: 7; fluvoxamine 200~400 mg/d: 4.
↵‡ Lorazepam-equivalent dose: 1.198 mg/d.
↵§ Quetiapine 25 mg/d, 1; quetiapine 50 mg/d, 2; aripiprazole 5 mg/d, 1.
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