Total brain | DEP | 27 | 37 | 2618 | 1123 | 1495 | −1.506 ± 4.127 (−9.595 to 6.583) | 0.72 | 0.000 | 0.28 | 0.00 |
| DEP-Mix | 12 | 13 | 1233 | 524 | 709 | 8.375 ± 6.116 (−3.612 to 20.361) | 0.17 | 0.000 | 0.18 | 0.00 |
| DEP-EO | 6 | 6 | 370 | 208 | 162 | 2.201 ± 11.192 (−19.734 to 24.136) | 0.84 | 0.000 | 0.85 | 0.00 |
| DEP-LO | 7 | 7 | 413 | 220 | 193 | 16.391 ± 12.855 (−8.805 to 41.587) | 0.20 | 688.646 | < 0.001* | 71.95* |
| DEP-Rem | 4 | 4 | 261 | 151 | 110 | 7.234 ± 16.222 (−24.561 to 39.029) | 0.66 | 0.000 | 0.93 | 0.00 |
| DEP-Cur | 4 | 4 | 617 | 295 | 322 | −7.031 ± 10.479 (−27.570 to 13.508) | 0.50 | 0.000 | 0.94 | 0.00 |
Grey matter | DEP | 15 | 19 | 1788 | 823 | 965 | 5.541 ± 2.437 (0.765 to 10.318) | 0.023* | 0.000 | 0.28 | 0.00 |
| DEP-Mix | 4 | 4 | 512 | 261 | 251 | 1.999 ± 5.425 (−8.633 to 12.632) | 0.71 | 0.000 | 0.61 | 0.00 |
| DEP-FE | 5 | 5 | 415 | 224 | 191 | 6.125 ± 4.440 (−2.578 to 14.827) | 0.17 | 0.000 | 0.55 | 0.00 |
| DEP-TR | 3 | 3 | 421 | 175 | 246 | 10.666 ± 8.021 (−5.054 to 26.387) | 0.18 | 93.016 | 0.14 | 47.89 |
White matter | DEP | 10 | 12 | 1245 | 508 | 737 | −2.351 ± 3.377 (−8.969 to 4.267) | 0.49 | 12.782 | 0.22 | 9.34 |
| DEP-Mix | 3 | 3 | 460 | 239 | 221 | −0.346 ± 5.599 (−11.320 to 10.628) | 0.95 | 0.000 | 0.69 | 0.00 |
| DEP-FE | 3 | 3 | 226 | 108 | 118 | 6.645 ± 9.677 (−12.323 to 25.612) | 0.49 | 75.471 | 0.24 | 25.98 |
Intracranial | DEP | 42 | 59 | 3775 | 1728 | 2047 | 5.806 ± 4.516 (−3.045 to 14.658) | 0.20 | 220.756 | 0.07 | 21.38 |
| DEP-Mix | 25 | 25 | 2235 | 1080 | 1155 | 11.731 ± 5.838 (0.288 to 23.173) | 0.045* | 121.417 | 0.28 | 15.50 |
| DEP-EO | 5 | 5 | 434 | 274 | 160 | 5.162 ± 18.859 (−31.800 to 42.125) | 0.78 | 839.154 | 0.11 | 48.09 |
| DEP-LO | 3 | 3 | 198 | 110 | 88 | 13.652 ± 18.797 (−23.189 to 50.492) | 0.47 | 0.000 | 0.54 | 0.00 |
| DEP-FE | 4 | 4 | 337 | 231 | 106 | 8.328 ± 18.012 (−26.975 to 43.631) | 0.64 | 327.309 | 0.27 | 23.99 |
| DEP-ME | 4 | 4 | 493 | 320 | 173 | 22.036 ± 20.536 (−18.214 to 62.286) | 0.28 | 919.847 | 0.06 | 56.87* |
| DEP-noMed | 6 | 6 | 302 | 176 | 126 | −18.519 ± 16.384 (−50.630 to 13.592) | 0.26 | 0.000 | 0.67 | 0.00 |
| DEP-Med | 4 | 4 | 192 | 137 | 55 | −0.831 ± 23.732 (−47.345 to 45.683) | 0.97 | 0.000 | 0.98 | 0.00 |
| DEP-TR | 3 | 3 | 366 | 138 | 228 | −0.749 ± 18.685 (−37.371 to 35.874) | 0.97 | 0.000 | 0.99 | 0.00 |
| DEP-Rem | 3 | 5 | 266 | 140 | 126 | −14.587 ± 14.135 (−42.291 to 13.116) | 0.30 | 0.000 | 0.31 | 0.00 |
| DEP-Cur | 5 | 5 | 386 | 210 | 176 | −6.795 ± 19.324 (−44.670 to 31.079) | 0.73 | 627.956 | 0.13 | 34.19 |
Total hippocampus | DEP | 42 | 61 | 3879 | 1737 | 2142 | 0.202 ± 0.040 (0.123 to 0.281) | < 0.001* | 0.072 | < 0.001* | 86.58* |
| DEP-Mix | 24 | 26 | 1826 | 881 | 945 | 0.267 ± 0.059 (0.150 to 0.383) | < 0.001* | 0.071 | < 0.001* | 83.25* |
| DEP-EO | 4 | 4 | 344 | 197 | 147 | 0.153 ± 0.096 (−0.035 to 0.340) | 0.11 | 0.019 | 0.09 | 53.55* |
| DEP-LO | 7 | 7 | 488 | 266 | 222 | 0.347 ± 0.100 (0.151 to 0.543) | < 0.001* | 0.049 | < 0.001* | 77.86* |
| DEP-FE | 7 | 8 | 497 | 310 | 187 | 0.105 ± 0.108 (−0.106 to 0.316) | 0.33 | 0.064 | < 0.001* | 73.46* |
| DEP-ME | 4 | 5 | 500 | 316 | 184 | 0.320 ± 0.091 (0.141 to 0.499) | < 0.001* | 0.024 | 0.011* | 68.43* |
| DEP-noMed | 3 | 3 | 138 | 74 | 64 | 0.121 ± 0.168 (−0.209 to 0.451) | 0.47 | 0.049 | 0.08 | 59.43* |
| DEP TR | 3 | 3 | 352 | 130 | 222 | 0.546 ± 0.284 (−0.011 to 1.103) | 0.05 | 0.207 | < 0.001* | 96.82* |
| DEP-Rem | 6 | 8 | 603 | 364 | 239 | −0.022 ± 0.050 (−0.121 to 0.076) | 0.66 | 0.000 | 0.84 | 0.00 |
| DEP-Cur | 7 | 7 | 967 | 464 | 503 | 0.108 ± 0.078 (−0.044 to 0.260) | 0.16 | 0.025 | 0.010* | 64.83* |
Right hippocampus | DEP | 34 | 50 | 3447 | 1544 | 1903 | 0.114 ± 0.023 (0.069 to 0.159) | < 0.001* | 0.017 | < 0.001* | 76.61* |
| DEP-Mix | 20 | 21 | 1594 | 783 | 811 | 0.137 ± 0.031 (0.075 to 0.198) | < 0.001* | 0.013 | < 0.001* | 68.44* |
| DEP-EO | 4 | 4 | 344 | 197 | 147 | 0.118 ± 0.054 (0.012 to 0.223) | 0.03* | 0.005 | 0.13 | 44.34 |
| DEP-LO | 6 | 6 | 451 | 244 | 207 | 0.204 ± 0.061 (0.085 to 0.323) | < 0.001* | 0.011 | 0.047* | 54.43* |
| DEP-FE | 7 | 8 | 497 | 310 | 187 | 0.047 ± 0.062 (−0.074 to 0.168) | 0.44 | 0.017 | 0.012* | 61.02* |
| DEP-ME | 4 | 5 | 500 | 316 | 184 | 0.183 ± 0.030 (0.125 to 0.242) | < 0.001* | 0.000 | 0.21 | 5.69 |
| DEP-Rem | 6 | 8 | 603 | 364 | 239 | −0.020 ± 0.033 (−0.085 to 0.046) | 0.56 | 0.000 | 0.93 | 0.00 |
| DEP-Cur | 5 | 5 | 847 | 409 | 438 | 0.052 ± 0.047 (−0.040 to 0.144) | 0.27 | 0.004 | 0.14 | 40.92 |
Left hippocampus | DEP | 34 | 50 | 3447 | 1544 | 1903 | 0.105 ± 0.023 (0.060 to 0.150) | < 0.001* | 0.017 | < 0.001* | 77.01* |
| DEP-Mix | 20 | 21 | 1594 | 783 | 811 | 0.133 ± 0.031 (0.071 to 0.194) | < 0.001* | 0.013 | < 0.001* | 67.97* |
| DEP-EO | 4 | 4 | 344 | 197 | 147 | 0.051 ± 0.041 (−0.030 to 0.132) | 0.21 | 0.001 | 0.31 | 14.68 |
| DEP-LO | 6 | 6 | 451 | 244 | 207 | 0.176 ± 0.049 (0.081 to 0.271) | < 0.001* | 0.005 | 0.18 | 34.90 |
| DEP-FE | 7 | 8 | 497 | 310 | 187 | 0.068 ± 0.052 (−0.033 to 0.169) | 0.19 | 0.011 | 0.040* | 52.77* |
| DEP-ME | 4 | 5 | 500 | 316 | 184 | 0.121 ± 0.054 (0.015 to 0.227) | 0.025* | 0.008 | 0.023* | 62.41* |
| DEP-Rem | 6 | 8 | 603 | 364 | 239 | −0.001 ± 0.034 (−0.067 to 0.065) | 0.98 | 0.000 | 0.79 | 0.00 |
| DEP-Cur | 5 | 5 | 847 | 409 | 438 | 0.042 ± 0.048 (−0.052 to 0.136) | 0.38 | 0.005 | 0.13 | 46.31 |
Total amygdala | DEP | 15 | 25 | 1181 | 463 | 718 | 0.091 ± 0.061 (−0.029 to 0.211) | 0.14 | 0.081 | < 0.001* | 90.25* |
| DEP-Mix | 6 | 6 | 362 | 167 | 195 | 0.018 ± 0.087 (−0.153 to 0.188) | 0.20 | 0.035 | 0.001* | 78.81* |
| DEP-FE | 3 | 3 | 177 | 91 | 86 | −0.146 ± 0.182 (−0.503 to 0.211) | 0.42 | 0.087 | < 0.001* | 89.00* |
| DEP-Rem | 5 | 7 | 274 | 138 | 136 | −0.035 ± 0.049 (−0.131 to 0.060) | 0.47 | 0.007 | 0.07 | 42.17 |
| DEP-Cur | 4 | 4 | 193 | 103 | 90 | −0.025 ± 0.092 (−0.204 to 0.155) | 0.79 | 0.017 | 0.12 | 50.56* |
Right amygdala | DEP | 13 | 23 | 1071 | 427 | 644 | 0.044 ± 0.029 (−0.014 to 0.101) | 0.14 | 0.014 | < 0.001* | 77.75* |
| DEP-Mix | 5 | 5 | 301 | 151 | 150 | 0.001 ± 0.035 (−0.067 to 0.069) | 0.98 | 0.002 | 0.19 | 31.11 |
| DEP-FE | 3 | 3 | 177 | 91 | 86 | −0.074 ± 0.087 (−0.244 to 0.096) | 0.40 | 0.016 | 0.017* | 73.80* |
| DEP-Rem | 5 | 7 | 274 | 138 | 136 | −0.016 ± 0.024 (−0.064 to 0.032) | 0.51 | 0.000 | 0.63 | 0.12 |
| DEP-Cur | 3 | 3 | 144 | 83 | 61 | −0.032 ± 0.038 (−0.106 to 0.043) | 0.40 | 0.000 | 0.83 | 0.00 |
Left amygdala | DEP | 13 | 23 | 1071 | 427 | 644 | 0.026 ± 0.035 (−0.042 to 0.095) | 0.45 | 0.022 | < 0.001* | 84.24* |
| DEP-Mix | 5 | 5 | 301 | 151 | 150 | −0.013 ± 0.053 (−0.117 to 0.090) | 0.80 | 0.010 | 0.008* | 72.34* |
| DEP-FE | 3 | 3 | 177 | 91 | 86 | −0.064 ± 0.099 (−0.257 to 0.130) | 0.52 | 0.024 | 0.001* | 82.32* |
| DEP-Rem | 5 | 7 | 274 | 138 | 136 | −0.027 ± 0.033 (−0.091 to 0.038) | 0.42 | 0.003 | 0.12 | 36.44 |
| DEP-Cur | 3 | 3 | 144 | 83 | 61 | −0.059 ± 0.037 (−0.132 to 0.013) | 0.11 | 0.000 | 0.88 | 0.00 |
Total putamen | DEP | 13 | 20 | 1693 | 716 | 977 | 0.212 ± 0.075 (0.065 to 0.359) | 0.005* | 0.059 | < 0.001* | 59.70* |
| DEP-Mix | 8 | 8 | 856 | 375 | 481 | 0.203 ± 0.074 (0.058 to 0.348) | 0.006* | 0.000 | 0.65 | 0.00 |
Right putamen | DEP | 9 | 15 | 1248 | 518 | 730 | 0.088 ± 0.044 (0.002 to 0.175) | 0.046* | 0.010 | 0.09 | 37.43 |
| DEP-Mix | 5 | 5 | 524 | 224 | 300 | 0.094 ± 0.062 (−0.028 to 0.215) | 0.13 | 0.000 | 0.86 | 0.00 |
Left putamen | DEP | 9 | 15 | 1248 | 518 | 730 | 0.081 ± 0.047 (−0.010 to 0.173) | 0.08 | 0.011 | 0.07 | 39.47 |
| DEP-Mix | 5 | 5 | 524 | 224 | 300 | 0.071 ± 0.059 (−0.044 to 0.187) | 0.23 | 0.000 | 0.73 | 0.00 |
Total caudate | DEP | 13 | 20 | 1686 | 697 | 989 | 0.031 ± 0.059 (−0.085 to 0.147) | 0.60 | 0.031 | 0.005* | 51.88* |
| DEP-Mix | 8 | 8 | 849 | 356 | 493 | 0.140 ± 0.086 (−0.028 to 0.308) | 0.10 | 0.016 | 0.24 | 28.16 |
Right caudate | DEP | 9 | 15 | 1241 | 499 | 742 | 0.017 ± 0.036 (−0.053 to 0.086) | 0.64 | 0.006 | 0.11 | 33.31 |
| DEP-Mix | 5 | 5 | 517 | 205 | 312 | 0.060 ± 0.051 (−0.039 to 0.160) | 0.23 | 0.000 | 0.38 | 1.71 |
Left caudate | DEP | 9 | 15 | 1241 | 499 | 742 | 0.021 ± 0.032 (−0.041 to 0.083) | 0.51 | 0.004 | 0.13 | 25.39 |
| DEP-Mix | 5 | 5 | 517 | 205 | 312 | 0.080 ± 0.053 (−0.024 to 0.184) | 0.13 | 0.003 | 0.23 | 24.11 |
Total pallidum | DEP | 9 | 16 | 1231 | 546 | 685 | 0.051 ± 0.028 (−0.004 to 0.106) | 0.07 | 0.008 | < 0.001* | 67.88* |
| DEP-Mix | 5 | 5 | 494 | 252 | 242 | 0.044 ± 0.038 (−0.031 to 0.118) | 0.25 | 0.003 | 0.18 | 38.94 |
Right pallidum | DEP | 7 | 13 | 947 | 411 | 536 | 0.028 ± 0.020 (−0.012 to 0.068) | 0.16 | 0.003 | < 0.001* | 64.66* |
| DEP-Mix | 3 | 3 | 223 | 117 | 106 | 0.054 ± 0.033 (−0.011 to 0.120) | 0.10 | 0.000 | 0.98 | 0.00 |
Left pallidum | DEP | 7 | 13 | 947 | 411 | 536 | 0.025 ± 0.015 (−0.004 to 0.054) | 0.09 | 0.001 | 0.14 | 19.16 |
| DEP-Mix | 3 | 3 | 223 | 117 | 106 | 0.018 ± 0.038 (−0.056 to 0.092) | 0.63 | 0.001 | 0.24 | 25.99 |
Total thalamus | DEP | 7 | 13 | 938 | 395 | 543 | 0.140 ± 0.194 (−0.242 to 0.520) | 0.47 | 0.400 | < 0.001* | 87.36* |
| DEP-Mix | 3 | 3 | 214 | 101 | 113 | 0.774 ± 0.184 (0.414 to 1.134) | < 0.001* | 0.000 | 0.75 | 0.00 |
Right thalamus | DEP | 6 | 12 | 874 | 363 | 511 | 0.091 ± 0.097 (−0.100 to 0.281) | 0.35 | 0.081 | < 0.001* | 76.54* |
Left thalamus | DEP | 6 | 12 | 874 | 363 | 511 | 0.036 ± 0.098 (−0.156 to 0.227) | 0.72 | 0.076 | < 0.001* | 73.60* |
Total accumbens | DEP | 4 | 9 | 563 | 226 | 337 | −0.018 ± 0.025 (−0.067 to 0.032) | 0.49 | 0.004 | < 0.001* | 69.57* |