All addictions > healthy controls |
Left angular gyrus, BA 39 | −52, −56, 30 | 1.769 | < 0.001 | 441 | Left angular gyrus, BA 39 (158) Left middle temporal gyrus, BA 21 (47) Left supramarginal gyrus, BA 40 (45) Left middle temporal gyrus, BA 22 (36) Left supramarginal gyrus, BA 22 (29) Left inferior parietal (excluding supramarginal and angular) gyri, BA 39 (23) Left supramarginal gyrus, BA 48 (22) Left angular gyrus, BA 22 (21) Left middle temporal gyrus, BA 39 (13) | 0.17 | 12/12 | No |
Left precentral gyrus, BA 6 | −22, −18, 72 | 1.449 | 0.001 | 69 | Left precentral gyrus, BA 6 (67) Left precentral gyrus (2) | 0.65 | 10/12 | No |
Right precuneus | 10, −52, 46 | 1.288 | 0.003 | 24 | Right precuneus (20) | 0.70 | 10/12 | No |
All addictions < healthy controls |
Right temporal pole, superior temporal gyrus, BA 38 | 30, 14, −26 | −1.572 | 0.001 | 318 | Right temporal pole, superior temporal gyrus, BA 38 (118) Right temporal pole, superior temporal gyrus (39) Right inferior frontal gyrus, orbital part, BA 38 (32) Right insula, BA 38 (20) Right parahippocampal gyrus, BA 28 (18) Right inferior frontal gyrus, orbital part (17) Right parahippocampal gyrus, BA 38 (11) | 0.015 | 10/12 | No |
Left striatum | −16, 16, −12 | −1.599 | < 0.001 | 193 | Left striatum (60) Left olfactory cortex, BA 25 (28) Left inferior network, uncinate fasciculus (19) Left superior frontal gyrus, orbital part, BA 11 (16) Left inferior frontal gyrus, orbital part, BA 11 (13) Left gyrus rectus, BA 11 (11) | 0.007 | 9/12 | Yes |
Left supplementary motor area, BA 6 | 0, 16, 62 | −1.685 | < 0.001 | 163 | Left supplementary motor area, BA 6 (75) Right supplementary motor area, BA 6 (32) Right supplementary motor area, BA 8 (18) Left supplementary motor area (16) | 0.34 | 10/12 | No |
Left inferior network, inferior longitudinal fasciculus | −36, −50, −10 | −1.766 | < 0.001 | 159 | Left inferior network, inferior longitudinal fasciculus (104) Left fusiform gyrus, BA 37 (39) Left inferior temporal gyrus, BA 37 (15) | 0.09 | 10/12 | No |
Left inferior frontal gyrus, triangular part, BA 45 | −50, 30, 6 | −1.466 | 0.001 | 26 | — | 0.88 | 10/12 | No |
Substance dependence > healthy controls |
Left angular gyrus, BA 39 | −54, −54, 32 | 1.548 | < 0.001 | 910 | Left angular gyrus, BA 39 (374) Left middle temporal gyrus, BA 21 (98) Left middle temporal gyrus, BA 39 (89) Left supramarginal gyrus, BA 40 (55) Left middle temporal gyrus, BA 22 (51) Left middle temporal gyrus, BA 37 (39) Left supramarginal gyrus, BA 22 (35) Left superior temporal gyrus, BA 22 (29) Left inferior parietal (excluding supramarginal and angular) gyri, BA 39 (23) Left angular gyrus, BA 22 (22) Left superior temporal gyrus, BA 42 (18) Left supramarginal gyrus, BA 42 (12) Left supramarginal gyrus, BA 48 (10) | 0.33 | 6/8 | No |
Corpus callosum | 22, −82, 24 | 1.307 | 0.002 | 160 | Corpus callosum (108) Right superior occipital gyrus, BA 19 (51) Right superior occipital gyrus, BA 18 (1) | 0.41 | 6/8 | No |
Left middle occipital gyrus, BA 39 | −40, −78, 18 | 1.125 | 0.004 | 24 | Left middle occipital gyrus, BA 39 (15) Left inferior network, inferior longitudinal fasciculus (5) Corpus callosum (3) Left middle occipital gyrus, BA 19 (1) | 0.93 | 6/8 | No |
Substance dependence < healthy controls |
Left striatum | −16, 16, −12 | −1.715 | < 0.001 | 353 | Left striatum (115) Left inferior frontal gyrus, orbital part, BA 11 (41) Left olfactory cortex, BA 25 (33) Left inferior network, uncinate fasciculus (29) Left superior frontal gyrus, orbital part, BA 11 (27) Left gyrus rectus, BA 11 (15) Corpus callosum (13) Left lenticular nucleus, putamen, BA 25 (13) | 0.012 | 8/8 | Yes |
Left inferior network, inferior longitudinal fasciculus | −36, −50, −12 | −1.442 | 0.002 | 129 | Left inferior network, inferior longitudinal fasciculus (78) Left fusiform gyrus, BA 37 (49) Left inferior temporal gyrus, BA 37 (2) | 0.12 | 6/8 | No |
Right inferior network, inferior fronto-occipital fasciculus | 34, −18, −4 | −1.493 | 0.002 | 68 | Right inferior network, inferior fronto-occipital fasciculus (18) Corpus callosum (11) Right lenticular nucleus, putamen, BA 48 (10) Right insula, BA 48 (4) Right striatum (2) | 0.17 | 6/8 | No |
Left middle frontal gyrus, BA 46 | −26, 46, 30 | −1.42 | 0.002 | 51 | Left middle frontal gyrus, BA 46 (37) Left middle frontal gyrus, BA 9 (9) Left middle frontal gyrus (5) | 0.07 | 6/8 | No |
Left supplementary motor area, BA 6 | −2, 12, 58 | −1.546 | < 0.001 | 45 | Left supplementary motor area, BA 6 (41) Left supplementary motor area (3) Right supplementary motor area, BA 6 (1) | 0.32 | 6/8 | No |
Right inferior network, inferior longitudinal fasciculus | 30, −22, −8 | −1.472 | 0.002 | 24 | Right hippocampus, BA 20 (10) Corpus callosum (5) Right inferior network, inferior longitudinal fasciculus (3) Right optic radiations (2) Right inferior network, inferior fronto-occipital fasciculus (1) | 0.26 | 6/8 | No |