Research Paper
Open Access
DCC gene network in the prefrontal cortex is associated with total brain volume in childhood
Alice Morgunova, Irina Pokhvisneva, Saara Nolvi, Sonja Entringer, Pathik Wadhwa, John Gilmore, Martin Styner, Claudia Buss, Roberto Britto Sassi, Geoffrey B.C. Hall, Kieran J. O’Donnell, Michael J. Meaney, Patricia P. Silveira and Cecilia A. Flores
J Psychiatry Neurosci January 01, 2021 46 (1) E154-E163; DOI: https://doi.org/10.1503/jpn.200081
Alice Morgunova
From the Integrated Program in Neuroscience (IPN), McGill University, Montréal, Que., Canada (Morgunova); the Department of Psychiatry, Faculty of Medicine, McGill University, Montréal, Que., Canada (O’Donnell, Meaney, Silveira, Flores); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que., Canada (Flores); the Douglas Research Centre, Montréal, Que., Canada (Morgunova, Flores, Silveira); the Ludmer Centre for Neuroinformatics and Mental Health, Douglas Research Centre, McGill University, Montréal, Que., Canada (Pokhvisneva, O’Donnell, Meaney, Silveira); the Child and Brain Development Program, Canadian Institute for Advanced Research (CIFAR), Toronto, Ont., Canada (O’Donnell, Meaney); the Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR; Meaney); the Department of Medical Psychology Charité Universitätsmedizin, Berlin, Germany (Nolvi, Buss); the FinnBrain Birth Cohort Study, Department of Clinical Medicine, University of Turku, Turku, Finland (Nolvi); the Development, Health and Disease Research Program, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Department of Pediatrics, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Entringer); the Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Obstetrics and Gynecology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Epidemiology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Gilmore, Styner); the Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Styner); the Mood Disorders Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ont., Canada (Sassi); and the Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, Ont., Canada (Hall)
BAIrina Pokhvisneva
From the Integrated Program in Neuroscience (IPN), McGill University, Montréal, Que., Canada (Morgunova); the Department of Psychiatry, Faculty of Medicine, McGill University, Montréal, Que., Canada (O’Donnell, Meaney, Silveira, Flores); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que., Canada (Flores); the Douglas Research Centre, Montréal, Que., Canada (Morgunova, Flores, Silveira); the Ludmer Centre for Neuroinformatics and Mental Health, Douglas Research Centre, McGill University, Montréal, Que., Canada (Pokhvisneva, O’Donnell, Meaney, Silveira); the Child and Brain Development Program, Canadian Institute for Advanced Research (CIFAR), Toronto, Ont., Canada (O’Donnell, Meaney); the Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR; Meaney); the Department of Medical Psychology Charité Universitätsmedizin, Berlin, Germany (Nolvi, Buss); the FinnBrain Birth Cohort Study, Department of Clinical Medicine, University of Turku, Turku, Finland (Nolvi); the Development, Health and Disease Research Program, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Department of Pediatrics, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Entringer); the Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Obstetrics and Gynecology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Epidemiology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Gilmore, Styner); the Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Styner); the Mood Disorders Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ont., Canada (Sassi); and the Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, Ont., Canada (Hall)
MScSaara Nolvi
From the Integrated Program in Neuroscience (IPN), McGill University, Montréal, Que., Canada (Morgunova); the Department of Psychiatry, Faculty of Medicine, McGill University, Montréal, Que., Canada (O’Donnell, Meaney, Silveira, Flores); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que., Canada (Flores); the Douglas Research Centre, Montréal, Que., Canada (Morgunova, Flores, Silveira); the Ludmer Centre for Neuroinformatics and Mental Health, Douglas Research Centre, McGill University, Montréal, Que., Canada (Pokhvisneva, O’Donnell, Meaney, Silveira); the Child and Brain Development Program, Canadian Institute for Advanced Research (CIFAR), Toronto, Ont., Canada (O’Donnell, Meaney); the Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR; Meaney); the Department of Medical Psychology Charité Universitätsmedizin, Berlin, Germany (Nolvi, Buss); the FinnBrain Birth Cohort Study, Department of Clinical Medicine, University of Turku, Turku, Finland (Nolvi); the Development, Health and Disease Research Program, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Department of Pediatrics, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Entringer); the Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Obstetrics and Gynecology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Epidemiology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Gilmore, Styner); the Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Styner); the Mood Disorders Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ont., Canada (Sassi); and the Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, Ont., Canada (Hall)
PhDSonja Entringer
From the Integrated Program in Neuroscience (IPN), McGill University, Montréal, Que., Canada (Morgunova); the Department of Psychiatry, Faculty of Medicine, McGill University, Montréal, Que., Canada (O’Donnell, Meaney, Silveira, Flores); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que., Canada (Flores); the Douglas Research Centre, Montréal, Que., Canada (Morgunova, Flores, Silveira); the Ludmer Centre for Neuroinformatics and Mental Health, Douglas Research Centre, McGill University, Montréal, Que., Canada (Pokhvisneva, O’Donnell, Meaney, Silveira); the Child and Brain Development Program, Canadian Institute for Advanced Research (CIFAR), Toronto, Ont., Canada (O’Donnell, Meaney); the Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR; Meaney); the Department of Medical Psychology Charité Universitätsmedizin, Berlin, Germany (Nolvi, Buss); the FinnBrain Birth Cohort Study, Department of Clinical Medicine, University of Turku, Turku, Finland (Nolvi); the Development, Health and Disease Research Program, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Department of Pediatrics, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Entringer); the Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Obstetrics and Gynecology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Epidemiology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Gilmore, Styner); the Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Styner); the Mood Disorders Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ont., Canada (Sassi); and the Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, Ont., Canada (Hall)
PhDPathik Wadhwa
From the Integrated Program in Neuroscience (IPN), McGill University, Montréal, Que., Canada (Morgunova); the Department of Psychiatry, Faculty of Medicine, McGill University, Montréal, Que., Canada (O’Donnell, Meaney, Silveira, Flores); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que., Canada (Flores); the Douglas Research Centre, Montréal, Que., Canada (Morgunova, Flores, Silveira); the Ludmer Centre for Neuroinformatics and Mental Health, Douglas Research Centre, McGill University, Montréal, Que., Canada (Pokhvisneva, O’Donnell, Meaney, Silveira); the Child and Brain Development Program, Canadian Institute for Advanced Research (CIFAR), Toronto, Ont., Canada (O’Donnell, Meaney); the Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR; Meaney); the Department of Medical Psychology Charité Universitätsmedizin, Berlin, Germany (Nolvi, Buss); the FinnBrain Birth Cohort Study, Department of Clinical Medicine, University of Turku, Turku, Finland (Nolvi); the Development, Health and Disease Research Program, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Department of Pediatrics, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Entringer); the Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Obstetrics and Gynecology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Epidemiology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Gilmore, Styner); the Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Styner); the Mood Disorders Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ont., Canada (Sassi); and the Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, Ont., Canada (Hall)
MD, PhDJohn Gilmore
From the Integrated Program in Neuroscience (IPN), McGill University, Montréal, Que., Canada (Morgunova); the Department of Psychiatry, Faculty of Medicine, McGill University, Montréal, Que., Canada (O’Donnell, Meaney, Silveira, Flores); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que., Canada (Flores); the Douglas Research Centre, Montréal, Que., Canada (Morgunova, Flores, Silveira); the Ludmer Centre for Neuroinformatics and Mental Health, Douglas Research Centre, McGill University, Montréal, Que., Canada (Pokhvisneva, O’Donnell, Meaney, Silveira); the Child and Brain Development Program, Canadian Institute for Advanced Research (CIFAR), Toronto, Ont., Canada (O’Donnell, Meaney); the Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR; Meaney); the Department of Medical Psychology Charité Universitätsmedizin, Berlin, Germany (Nolvi, Buss); the FinnBrain Birth Cohort Study, Department of Clinical Medicine, University of Turku, Turku, Finland (Nolvi); the Development, Health and Disease Research Program, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Department of Pediatrics, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Entringer); the Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Obstetrics and Gynecology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Epidemiology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Gilmore, Styner); the Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Styner); the Mood Disorders Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ont., Canada (Sassi); and the Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, Ont., Canada (Hall)
MDMartin Styner
From the Integrated Program in Neuroscience (IPN), McGill University, Montréal, Que., Canada (Morgunova); the Department of Psychiatry, Faculty of Medicine, McGill University, Montréal, Que., Canada (O’Donnell, Meaney, Silveira, Flores); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que., Canada (Flores); the Douglas Research Centre, Montréal, Que., Canada (Morgunova, Flores, Silveira); the Ludmer Centre for Neuroinformatics and Mental Health, Douglas Research Centre, McGill University, Montréal, Que., Canada (Pokhvisneva, O’Donnell, Meaney, Silveira); the Child and Brain Development Program, Canadian Institute for Advanced Research (CIFAR), Toronto, Ont., Canada (O’Donnell, Meaney); the Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR; Meaney); the Department of Medical Psychology Charité Universitätsmedizin, Berlin, Germany (Nolvi, Buss); the FinnBrain Birth Cohort Study, Department of Clinical Medicine, University of Turku, Turku, Finland (Nolvi); the Development, Health and Disease Research Program, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Department of Pediatrics, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Entringer); the Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Obstetrics and Gynecology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Epidemiology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Gilmore, Styner); the Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Styner); the Mood Disorders Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ont., Canada (Sassi); and the Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, Ont., Canada (Hall)
MSc, PhDClaudia Buss
From the Integrated Program in Neuroscience (IPN), McGill University, Montréal, Que., Canada (Morgunova); the Department of Psychiatry, Faculty of Medicine, McGill University, Montréal, Que., Canada (O’Donnell, Meaney, Silveira, Flores); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que., Canada (Flores); the Douglas Research Centre, Montréal, Que., Canada (Morgunova, Flores, Silveira); the Ludmer Centre for Neuroinformatics and Mental Health, Douglas Research Centre, McGill University, Montréal, Que., Canada (Pokhvisneva, O’Donnell, Meaney, Silveira); the Child and Brain Development Program, Canadian Institute for Advanced Research (CIFAR), Toronto, Ont., Canada (O’Donnell, Meaney); the Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR; Meaney); the Department of Medical Psychology Charité Universitätsmedizin, Berlin, Germany (Nolvi, Buss); the FinnBrain Birth Cohort Study, Department of Clinical Medicine, University of Turku, Turku, Finland (Nolvi); the Development, Health and Disease Research Program, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Department of Pediatrics, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Entringer); the Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Obstetrics and Gynecology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Epidemiology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Gilmore, Styner); the Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Styner); the Mood Disorders Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ont., Canada (Sassi); and the Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, Ont., Canada (Hall)
PhDRoberto Britto Sassi
From the Integrated Program in Neuroscience (IPN), McGill University, Montréal, Que., Canada (Morgunova); the Department of Psychiatry, Faculty of Medicine, McGill University, Montréal, Que., Canada (O’Donnell, Meaney, Silveira, Flores); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que., Canada (Flores); the Douglas Research Centre, Montréal, Que., Canada (Morgunova, Flores, Silveira); the Ludmer Centre for Neuroinformatics and Mental Health, Douglas Research Centre, McGill University, Montréal, Que., Canada (Pokhvisneva, O’Donnell, Meaney, Silveira); the Child and Brain Development Program, Canadian Institute for Advanced Research (CIFAR), Toronto, Ont., Canada (O’Donnell, Meaney); the Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR; Meaney); the Department of Medical Psychology Charité Universitätsmedizin, Berlin, Germany (Nolvi, Buss); the FinnBrain Birth Cohort Study, Department of Clinical Medicine, University of Turku, Turku, Finland (Nolvi); the Development, Health and Disease Research Program, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Department of Pediatrics, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Entringer); the Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Obstetrics and Gynecology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Epidemiology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Gilmore, Styner); the Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Styner); the Mood Disorders Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ont., Canada (Sassi); and the Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, Ont., Canada (Hall)
MDGeoffrey B.C. Hall
From the Integrated Program in Neuroscience (IPN), McGill University, Montréal, Que., Canada (Morgunova); the Department of Psychiatry, Faculty of Medicine, McGill University, Montréal, Que., Canada (O’Donnell, Meaney, Silveira, Flores); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que., Canada (Flores); the Douglas Research Centre, Montréal, Que., Canada (Morgunova, Flores, Silveira); the Ludmer Centre for Neuroinformatics and Mental Health, Douglas Research Centre, McGill University, Montréal, Que., Canada (Pokhvisneva, O’Donnell, Meaney, Silveira); the Child and Brain Development Program, Canadian Institute for Advanced Research (CIFAR), Toronto, Ont., Canada (O’Donnell, Meaney); the Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR; Meaney); the Department of Medical Psychology Charité Universitätsmedizin, Berlin, Germany (Nolvi, Buss); the FinnBrain Birth Cohort Study, Department of Clinical Medicine, University of Turku, Turku, Finland (Nolvi); the Development, Health and Disease Research Program, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Department of Pediatrics, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Entringer); the Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Obstetrics and Gynecology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Epidemiology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Gilmore, Styner); the Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Styner); the Mood Disorders Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ont., Canada (Sassi); and the Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, Ont., Canada (Hall)
MSc, PhDKieran J. O’Donnell
From the Integrated Program in Neuroscience (IPN), McGill University, Montréal, Que., Canada (Morgunova); the Department of Psychiatry, Faculty of Medicine, McGill University, Montréal, Que., Canada (O’Donnell, Meaney, Silveira, Flores); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que., Canada (Flores); the Douglas Research Centre, Montréal, Que., Canada (Morgunova, Flores, Silveira); the Ludmer Centre for Neuroinformatics and Mental Health, Douglas Research Centre, McGill University, Montréal, Que., Canada (Pokhvisneva, O’Donnell, Meaney, Silveira); the Child and Brain Development Program, Canadian Institute for Advanced Research (CIFAR), Toronto, Ont., Canada (O’Donnell, Meaney); the Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR; Meaney); the Department of Medical Psychology Charité Universitätsmedizin, Berlin, Germany (Nolvi, Buss); the FinnBrain Birth Cohort Study, Department of Clinical Medicine, University of Turku, Turku, Finland (Nolvi); the Development, Health and Disease Research Program, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Department of Pediatrics, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Entringer); the Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Obstetrics and Gynecology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Epidemiology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Gilmore, Styner); the Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Styner); the Mood Disorders Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ont., Canada (Sassi); and the Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, Ont., Canada (Hall)
PhDMichael J. Meaney
From the Integrated Program in Neuroscience (IPN), McGill University, Montréal, Que., Canada (Morgunova); the Department of Psychiatry, Faculty of Medicine, McGill University, Montréal, Que., Canada (O’Donnell, Meaney, Silveira, Flores); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que., Canada (Flores); the Douglas Research Centre, Montréal, Que., Canada (Morgunova, Flores, Silveira); the Ludmer Centre for Neuroinformatics and Mental Health, Douglas Research Centre, McGill University, Montréal, Que., Canada (Pokhvisneva, O’Donnell, Meaney, Silveira); the Child and Brain Development Program, Canadian Institute for Advanced Research (CIFAR), Toronto, Ont., Canada (O’Donnell, Meaney); the Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR; Meaney); the Department of Medical Psychology Charité Universitätsmedizin, Berlin, Germany (Nolvi, Buss); the FinnBrain Birth Cohort Study, Department of Clinical Medicine, University of Turku, Turku, Finland (Nolvi); the Development, Health and Disease Research Program, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Department of Pediatrics, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Entringer); the Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Obstetrics and Gynecology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Epidemiology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Gilmore, Styner); the Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Styner); the Mood Disorders Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ont., Canada (Sassi); and the Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, Ont., Canada (Hall)
PhDPatricia P. Silveira
From the Integrated Program in Neuroscience (IPN), McGill University, Montréal, Que., Canada (Morgunova); the Department of Psychiatry, Faculty of Medicine, McGill University, Montréal, Que., Canada (O’Donnell, Meaney, Silveira, Flores); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que., Canada (Flores); the Douglas Research Centre, Montréal, Que., Canada (Morgunova, Flores, Silveira); the Ludmer Centre for Neuroinformatics and Mental Health, Douglas Research Centre, McGill University, Montréal, Que., Canada (Pokhvisneva, O’Donnell, Meaney, Silveira); the Child and Brain Development Program, Canadian Institute for Advanced Research (CIFAR), Toronto, Ont., Canada (O’Donnell, Meaney); the Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR; Meaney); the Department of Medical Psychology Charité Universitätsmedizin, Berlin, Germany (Nolvi, Buss); the FinnBrain Birth Cohort Study, Department of Clinical Medicine, University of Turku, Turku, Finland (Nolvi); the Development, Health and Disease Research Program, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Department of Pediatrics, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Entringer); the Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Obstetrics and Gynecology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Epidemiology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Gilmore, Styner); the Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Styner); the Mood Disorders Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ont., Canada (Sassi); and the Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, Ont., Canada (Hall)
MD, MSc, PhDCecilia A. Flores
From the Integrated Program in Neuroscience (IPN), McGill University, Montréal, Que., Canada (Morgunova); the Department of Psychiatry, Faculty of Medicine, McGill University, Montréal, Que., Canada (O’Donnell, Meaney, Silveira, Flores); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que., Canada (Flores); the Douglas Research Centre, Montréal, Que., Canada (Morgunova, Flores, Silveira); the Ludmer Centre for Neuroinformatics and Mental Health, Douglas Research Centre, McGill University, Montréal, Que., Canada (Pokhvisneva, O’Donnell, Meaney, Silveira); the Child and Brain Development Program, Canadian Institute for Advanced Research (CIFAR), Toronto, Ont., Canada (O’Donnell, Meaney); the Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR; Meaney); the Department of Medical Psychology Charité Universitätsmedizin, Berlin, Germany (Nolvi, Buss); the FinnBrain Birth Cohort Study, Department of Clinical Medicine, University of Turku, Turku, Finland (Nolvi); the Development, Health and Disease Research Program, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Department of Pediatrics, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Entringer); the Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Obstetrics and Gynecology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Epidemiology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Gilmore, Styner); the Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Styner); the Mood Disorders Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ont., Canada (Sassi); and the Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, Ont., Canada (Hall)
MSc, PhDArticle Information
vol. 46 no. 1 E154-E163
PubMed
History
- Received April 26, 2020
- Revision received July 22, 2020
- Accepted August 14, 2020
- Published online January 1, 2021.
Copyright & Usage
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Author Information
- Alice Morgunova, BA,
- Irina Pokhvisneva, MSc,
- Saara Nolvi, PhD,
- Sonja Entringer, PhD,
- Pathik Wadhwa, MD, PhD,
- John Gilmore, MD,
- Martin Styner, MSc, PhD,
- Claudia Buss, PhD,
- Roberto Britto Sassi, MD,
- Geoffrey B.C. Hall, MSc, PhD,
- Kieran J. O’Donnell, PhD,
- Michael J. Meaney, PhD,
- Patricia P. Silveira, MD, MSc, PhD,
- Cecilia A. Flores, MSc, PhD
- From the Integrated Program in Neuroscience (IPN), McGill University, Montréal, Que., Canada (Morgunova); the Department of Psychiatry, Faculty of Medicine, McGill University, Montréal, Que., Canada (O’Donnell, Meaney, Silveira, Flores); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que., Canada (Flores); the Douglas Research Centre, Montréal, Que., Canada (Morgunova, Flores, Silveira); the Ludmer Centre for Neuroinformatics and Mental Health, Douglas Research Centre, McGill University, Montréal, Que., Canada (Pokhvisneva, O’Donnell, Meaney, Silveira); the Child and Brain Development Program, Canadian Institute for Advanced Research (CIFAR), Toronto, Ont., Canada (O’Donnell, Meaney); the Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR; Meaney); the Department of Medical Psychology Charité Universitätsmedizin, Berlin, Germany (Nolvi, Buss); the FinnBrain Birth Cohort Study, Department of Clinical Medicine, University of Turku, Turku, Finland (Nolvi); the Development, Health and Disease Research Program, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Department of Pediatrics, School of Medicine, University of California, Irvine, Irvine, CA, USA (Entringer, Wadhwa); the Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Entringer); the Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Obstetrics and Gynecology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Epidemiology, School of Medicine, University of California, Irvine, CA, USA (Wadhwa); the Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Gilmore, Styner); the Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Styner); the Mood Disorders Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ont., Canada (Sassi); and the Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, Ont., Canada (Hall)
- Correspondence to: C. Flores, Department of Psychiatry, Douglas Mental Health University Institute, Perry Pavilion, Room 2111, 6875 La- Salle Boulevard, Montréal (Verdun), Quebec H4H 1R3, Canada; cecilia.flores{at}mcgill.ca; P. Silveira, MD Department of Psychiatry and Ludmer Centre for Neuroinformatics and Mental Health, Douglas Research Centre, McGill University, Montréal, Quebec, H4H 1R3, Canada; patricia.silveira{at}mcgill.ca
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DCC gene network in the prefrontal cortex is associated with total brain volume in childhood
Alice Morgunova, Irina Pokhvisneva, Saara Nolvi, Sonja Entringer, Pathik Wadhwa, John Gilmore, Martin Styner, Claudia Buss, Roberto Britto Sassi, Geoffrey B.C. Hall, Kieran J. O’Donnell, Michael J. Meaney, Patricia P. Silveira, Cecilia A. Flores
J Psychiatry Neurosci Jan 2021, 46 (1) E154-E163; DOI: 10.1503/jpn.200081
DCC gene network in the prefrontal cortex is associated with total brain volume in childhood
Alice Morgunova, Irina Pokhvisneva, Saara Nolvi, Sonja Entringer, Pathik Wadhwa, John Gilmore, Martin Styner, Claudia Buss, Roberto Britto Sassi, Geoffrey B.C. Hall, Kieran J. O’Donnell, Michael J. Meaney, Patricia P. Silveira, Cecilia A. Flores
J Psychiatry Neurosci Jan 2021, 46 (1) E154-E163; DOI: 10.1503/jpn.200081
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