Skip to main content

Main menu

  • Home
  • Issues
    • Issue in progress
    • Issues by date
  • Sections
    • Editorial
    • Review
    • Research
    • Commentary
    • Psychopharmacology for the Clinician
    • Letters to the Editor
  • Topic Collections
  • Instructions for Authors
    • Overview for authors
    • Submission checklist
    • Editorial policies
    • Publication fees
    • Submit a manuscript
    • Dr. Francis Wayne Quan Memorial Prize
    • Open access
  • Alerts
    • Email alerts
    • RSS
  • About
    • General information
    • Staff
    • Editorial Board
    • Contact
  • CMAJ JOURNALS
    • CMAJ
    • CMAJ Open
    • CJS
    • JAMC

User menu

Search

  • Advanced search
JPN
  • CMAJ JOURNALS
    • CMAJ
    • CMAJ Open
    • CJS
    • JAMC
JPN

Advanced Search

  • Home
  • Issues
    • Issue in progress
    • Issues by date
  • Sections
    • Editorial
    • Review
    • Research
    • Commentary
    • Psychopharmacology for the Clinician
    • Letters to the Editor
  • Topic Collections
  • Instructions for Authors
    • Overview for authors
    • Submission checklist
    • Editorial policies
    • Publication fees
    • Submit a manuscript
    • Dr. Francis Wayne Quan Memorial Prize
    • Open access
  • Alerts
    • Email alerts
    • RSS
  • About
    • General information
    • Staff
    • Editorial Board
    • Contact
  • Subscribe to our alerts
  • RSS feeds
  • Follow JPN on Twitter
Research Paper
Open Access

Thalamocortical functional connectivity in patients with insomnia using resting-state fMRI

Nambeom Kim, Eunsoo Won, Seo-Eun Cho, Chang-Ki Kang and Seung-Gul Kang
J Psychiatry Neurosci November 01, 2021 46 (6) E639-E646; DOI: https://doi.org/10.1503/jpn.210066
Nambeom Kim
From the Department of Biomedical Engineering Research Center (N. Kim); Department of Psychiatry (S.-G. Kang, S.-E. Cho), Gil Medical Center, College of Medicine; and Department of Radiological Science (C.-K. Kang), College of Health Science, Gachon University, Incheon, Republic of Korea; Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea (E. Won); Department of Psychiatry, Chaum, Seoul, Republic of Korea (E. Won)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Eunsoo Won
From the Department of Biomedical Engineering Research Center (N. Kim); Department of Psychiatry (S.-G. Kang, S.-E. Cho), Gil Medical Center, College of Medicine; and Department of Radiological Science (C.-K. Kang), College of Health Science, Gachon University, Incheon, Republic of Korea; Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea (E. Won); Department of Psychiatry, Chaum, Seoul, Republic of Korea (E. Won)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Seo-Eun Cho
From the Department of Biomedical Engineering Research Center (N. Kim); Department of Psychiatry (S.-G. Kang, S.-E. Cho), Gil Medical Center, College of Medicine; and Department of Radiological Science (C.-K. Kang), College of Health Science, Gachon University, Incheon, Republic of Korea; Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea (E. Won); Department of Psychiatry, Chaum, Seoul, Republic of Korea (E. Won)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Chang-Ki Kang
From the Department of Biomedical Engineering Research Center (N. Kim); Department of Psychiatry (S.-G. Kang, S.-E. Cho), Gil Medical Center, College of Medicine; and Department of Radiological Science (C.-K. Kang), College of Health Science, Gachon University, Incheon, Republic of Korea; Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea (E. Won); Department of Psychiatry, Chaum, Seoul, Republic of Korea (E. Won)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Seung-Gul Kang
From the Department of Biomedical Engineering Research Center (N. Kim); Department of Psychiatry (S.-G. Kang, S.-E. Cho), Gil Medical Center, College of Medicine; and Department of Radiological Science (C.-K. Kang), College of Health Science, Gachon University, Incheon, Republic of Korea; Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea (E. Won); Department of Psychiatry, Chaum, Seoul, Republic of Korea (E. Won)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Tables
  • Related Content
  • Responses
  • Metrics
  • PDF
Loading

Article Figures & Tables

Figures

  • Tables
  • Figure 1
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 1

    Cortical areas of increased thalamocortical functional connectivity in participants with insomnia compared with healthy controls. (A and B) The seed is the right thalamus. The insomnia group showed increased functional connectivity in the right superior medial frontal area, bilateral middle temporal areas, right parahippocampal gyrus and left rectus (areas in red) with the right thalamus compared with the healthy control group. (C and D) The seed is the left thalamus. The insomnia group showed increased functional connectivity in the left superior parietal area, both mid-temporal poles and left rectus (areas in red) with the left thalamus compared with the healthy control group. The green and red contours represent the left and right seeds of the thalamus, respectively. The statistical threshold was a voxel-wise uncorrected p < 0.001, with a cluster-wise false discovery rate corrected p < 0.05.

  • Figure 2
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 2

    Mean and standard errors for Fisher z-scores of resting-state functional connectivity between the thalamus and cortical regions. Resting-state functional connectivity was defined as Fisher z-scores in the INS and CON groups. (A) Correlations between the right thalamus and cortical regions and (B) between the left thalamus and cortical regions. Bars and whiskers represent means and standard errors. CON = healthy control; Frontal_Sup_Medial_R = right medial superior frontal area; INS = insomnia; ParaHippocampal_R = right parahippocampal area; Parietal_Sup_L = left superior parietal area; Rectus_L = left rectus; Temporal_Mid_R = right middle temporal area; Temporal_Pole_Mid_L = left middle temporal pole; Temporal_Pole_Mid_R = right middle temporal pole.

Tables

  • Figures
    • View popup
    Table 1

    Demographic and clinical characteristics of the participants

    CharacteristicInsomnia disorder
    n = 50
    Healthy control
    n = 42
    Statistics
    Age, yr43.3 ± 13.936.2 ± 11.2t = 2.71, p = 0.008
    Sex, female33 (66.0)26 (61.9)χ2 = 0.17, p = 0.7
    Duration of insomnia disorder, yr6.9 ± 7.8—
    Duration of education, yr13.6 ± 3.815.4 ± 2.0t = −2.88, p = 0.005
    PSQI*
    Total score12.9 ± 3.62.4 ± 1.3t = 19.25, p < 0.001
    TST, min281.8 ± 89.0445.5 ± 53.8t = −10.86, p < 0.001
    SE, %64.9 ± 20.096.2 ± 4.2t = −10.79, p < 0.001
    ISI score*18.5 ± 4.81.3 ± 1.7t = 23.73, p < 0.001
    Polysomnographic data
    TST, min346.9 ± 73.3394.3 ± 65.4t = −3.24, p = 0.002
    SE, %77.7 ± 12.391.1 ± 7.1t = −6.51, p < 0.001
    WASO, min73.2 ± 56.831.9 ± 29.2t = 4.48, p < 0.001
    AHI, no./h3.4 ± 3.43.0 ± 4.4t = 0.54, p = 0.6
    • AHI = apnea–hypopnea index; ISI = Insomnia Severity Index; PSQI = Pittsburgh Sleep Quality Index; SE = sleep efficiency; SOL = sleep onset latency; TST = total sleep time; WASO = wake-after-sleep onset.

    • Values are reported as mean ± standard deviation or n (%).

    • ↵* These scales were completed on the date of the brain MRI scanning.

    • View popup
    Table 2

    Coordinates of increased thalamocortical functional connectivity in participants with insomnia compared with healthy controls

    SeedConnected cortical regionMNI coordinates (x, y, z)Cluster sizez-score
    Right thalamusFrontal_Sup_Medial_R858121553.98
    Temporal_Pole_Mid_L−5412−341453.91
    ParaHippocampal_R30−32−161563.91
    Temporal_Mid_R66−4−202873.83
    Rectus_L−248−161543.77
    Left thalamusParietal_Sup_L−18−60523444.38
    Temporal_Pole_Mid_R4816−323374.27
    Rectus_L−448−161593.97
    Temporal_Pole_Mid_L−4412−341893.93
    • Frontal_Sup_Medial_R = right medial superior frontal area; MNI = Montreal Neurological Institute; ParaHippocampal_R = right parahippocampal area; Parietal_Sup_L = left superior parietal area; Rectus_L = left rectus; Temporal_Mid_R = right middle temporal area; Temporal_Pole_Mid_L = left middle temporal pole; Temporal_Pole_Mid_R = right middle temporal pole.

    • We performed this analysis after controlling for age, sex and education level.

    • View popup
    Table 3

    Partial correlation coefficients between sleep efficiency and functional connectivity in the insomnia group

    Clinical indexSeedConnected cortical regionPearson coefficientp value
    Sleep efficiency from PSGRight thalamusFrontal_Sup_Medial_R−0.280.049
    Temporal_Pole_Mid_L−0.2840.045
    ParaHippocampal_R−0.2950.04
    Temporal_Mid_R−0.2190.1
    Rectus_L−0.1810.2
    Left thalamusParietal_Sup_L0.0360.8
    Temporal_Pole_Mid_R−0.3640.009
    Rectus_L−0.1130.4
    Temporal_Pole_Mid_L−0.2290.035
    • Frontal_Sup_Medial_R = right medial superior frontal area; ParaHippocampal_R = right parahippocampal area; Parietal_Sup_L = left superior parietal area; PSG = polysomnography; Rectus_L = left rectus; Temporal_Mid_R = right middle temporal area; Temporal_Pole_Mid_L = left middle temporal pole; Temporal_Pole_Mid_R = right middle temporal pole.

    • We performed the partial correlation analysis between sleep efficiency from PSG and thalamocortical connectivity after controlling for age, sex and educational level.

PreviousNext
Back to top

In this issue

Journal of Psychiatry and Neuroscience: 46 (6)
J Psychiatry Neurosci
Vol. 46, Issue 6
21 Dec 2021
  • Table of Contents
  • Index by author

Article tools

Respond to this article
Print
Download PDF
Article Alerts
To sign up for email alerts or to access your current email alerts, enter your email address below:
Email Article

Thank you for your interest in spreading the word on JPN.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Thalamocortical functional connectivity in patients with insomnia using resting-state fMRI
(Your Name) has sent you a message from JPN
(Your Name) thought you would like to see the JPN web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Thalamocortical functional connectivity in patients with insomnia using resting-state fMRI
Nambeom Kim, Eunsoo Won, Seo-Eun Cho, Chang-Ki Kang, Seung-Gul Kang
J Psychiatry Neurosci Nov 2021, 46 (6) E639-E646; DOI: 10.1503/jpn.210066

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
‍ Request Permissions
Share
Thalamocortical functional connectivity in patients with insomnia using resting-state fMRI
Nambeom Kim, Eunsoo Won, Seo-Eun Cho, Chang-Ki Kang, Seung-Gul Kang
J Psychiatry Neurosci Nov 2021, 46 (6) E639-E646; DOI: 10.1503/jpn.210066
Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like

Related Articles

  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

Similar Articles

Content

  • Current issue
  • Past issues
  • Collections
  • Alerts
  • RSS

Authors & Reviewers

  • Overview for Authors
  • Submit a manuscript
  • Manuscript Submission Checklist

About

  • General Information
  • Staff
  • Editorial Board
  • Contact Us
  • Advertising
  • Reprints
  • Copyright and Permissions
  • Accessibility
  • CMA Civility Standards
CMAJ Group

Copyright 2022, CMA Impact Inc. or its licensors. All rights reserved. ISSN 1180-4882.

All editorial matter in JPN represents the opinions of the authors and not necessarily those of the Canadian Medical Association or its subsidiaries.
To receive any of these resources in an accessible format, please contact us at CMAJ Group, 500-1410 Blair Towers Place, Ottawa ON, K1J 9B9; p: 1-888-855-2555; e: [email protected].
View CMA's Accessibility policy.

Powered by HighWire