Social anxiety disorder → DNA methylation | −0.008 ± 0.004 | −1.75 | 0.08 | −0.016 to 0.001 |
Early-life adversity → DNA methylation | −0.008 ± 0.004 | −1.77 | 0.08 | −0.017 to 0.001 |
Social anxiety disorder × early-life adversity → DNA methylation | 0.024 ± 0.007 | 3.63 | < 0.001 | 0.011 to 0.037 |
DNA methylation → brain activity | −13.377 ± 6.497 | −2.06 | 0.043 | −26.314 to −0.441 |
Social anxiety disorder → brain activity | 0.674 ± 0.256 | 2.63 | 0.010 | 0.164 to 1.184 |
Early-life adversity → brain activity | 0.958 ± 0.270 | 3.55 | < 0.001 | 0.421 to 1.495 |
Social anxiety disorder × early-life adversity → brain activity | −1.506 ± 0.403 | −3.74 | < 0.001 | −2.308 to −0.705 |
Social anxiety disorder × early-life adversity → DNA methylation → brain activity* | −0.315 ± 0.164 | — | — | −0.688 to −0.050† |