Research Paper
Open Access
Peptidergic neurons of the Edinger–Westphal nucleus express TRPA1 ion channel that is downregulated both upon chronic variable mild stress in male mice and in humans who died by suicide
Viktória Kormos, Angéla Kecskés, József Farkas, Tamás Gaszner, Valér Csernus, Ammar Alomari, Dániel Hegedüs, Éva Renner, Miklós Palkovits, Dóra Zelena, Zsuzsanna Helyes, Erika Pintér and Balázs Gaszner
J Psychiatry Neurosci May 04, 2022 47 (3) E162-E175; DOI: https://doi.org/10.1503/jpn.210187
Viktória Kormos
From the Department of Pharmacology and Pharmacotherapy, Medical School and Molecular Pharmacology Research Group, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Kormos, Kecskés, Alomari, Hegedüs, Helyes, Pintér); the Department of Anatomy, Medical School and Research Group for Mood Disorders, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Farkas, T. Gaszner, Csernus, Hegedüs, B. Gaszner); Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary (Renner, Palkovits); the Department of Physiology, Medical School, Szentágothai Research Centre, Centre for Neuroscience, University of Pécs, Pécs, Hungary (Zelena); Pharm-InVivo Ltd., Pécs, Hungary (Helyes, Pintér)
Angéla Kecskés
From the Department of Pharmacology and Pharmacotherapy, Medical School and Molecular Pharmacology Research Group, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Kormos, Kecskés, Alomari, Hegedüs, Helyes, Pintér); the Department of Anatomy, Medical School and Research Group for Mood Disorders, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Farkas, T. Gaszner, Csernus, Hegedüs, B. Gaszner); Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary (Renner, Palkovits); the Department of Physiology, Medical School, Szentágothai Research Centre, Centre for Neuroscience, University of Pécs, Pécs, Hungary (Zelena); Pharm-InVivo Ltd., Pécs, Hungary (Helyes, Pintér)
József Farkas
From the Department of Pharmacology and Pharmacotherapy, Medical School and Molecular Pharmacology Research Group, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Kormos, Kecskés, Alomari, Hegedüs, Helyes, Pintér); the Department of Anatomy, Medical School and Research Group for Mood Disorders, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Farkas, T. Gaszner, Csernus, Hegedüs, B. Gaszner); Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary (Renner, Palkovits); the Department of Physiology, Medical School, Szentágothai Research Centre, Centre for Neuroscience, University of Pécs, Pécs, Hungary (Zelena); Pharm-InVivo Ltd., Pécs, Hungary (Helyes, Pintér)
Tamás Gaszner
From the Department of Pharmacology and Pharmacotherapy, Medical School and Molecular Pharmacology Research Group, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Kormos, Kecskés, Alomari, Hegedüs, Helyes, Pintér); the Department of Anatomy, Medical School and Research Group for Mood Disorders, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Farkas, T. Gaszner, Csernus, Hegedüs, B. Gaszner); Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary (Renner, Palkovits); the Department of Physiology, Medical School, Szentágothai Research Centre, Centre for Neuroscience, University of Pécs, Pécs, Hungary (Zelena); Pharm-InVivo Ltd., Pécs, Hungary (Helyes, Pintér)
Valér Csernus
From the Department of Pharmacology and Pharmacotherapy, Medical School and Molecular Pharmacology Research Group, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Kormos, Kecskés, Alomari, Hegedüs, Helyes, Pintér); the Department of Anatomy, Medical School and Research Group for Mood Disorders, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Farkas, T. Gaszner, Csernus, Hegedüs, B. Gaszner); Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary (Renner, Palkovits); the Department of Physiology, Medical School, Szentágothai Research Centre, Centre for Neuroscience, University of Pécs, Pécs, Hungary (Zelena); Pharm-InVivo Ltd., Pécs, Hungary (Helyes, Pintér)
Ammar Alomari
From the Department of Pharmacology and Pharmacotherapy, Medical School and Molecular Pharmacology Research Group, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Kormos, Kecskés, Alomari, Hegedüs, Helyes, Pintér); the Department of Anatomy, Medical School and Research Group for Mood Disorders, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Farkas, T. Gaszner, Csernus, Hegedüs, B. Gaszner); Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary (Renner, Palkovits); the Department of Physiology, Medical School, Szentágothai Research Centre, Centre for Neuroscience, University of Pécs, Pécs, Hungary (Zelena); Pharm-InVivo Ltd., Pécs, Hungary (Helyes, Pintér)
Dániel Hegedüs
From the Department of Pharmacology and Pharmacotherapy, Medical School and Molecular Pharmacology Research Group, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Kormos, Kecskés, Alomari, Hegedüs, Helyes, Pintér); the Department of Anatomy, Medical School and Research Group for Mood Disorders, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Farkas, T. Gaszner, Csernus, Hegedüs, B. Gaszner); Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary (Renner, Palkovits); the Department of Physiology, Medical School, Szentágothai Research Centre, Centre for Neuroscience, University of Pécs, Pécs, Hungary (Zelena); Pharm-InVivo Ltd., Pécs, Hungary (Helyes, Pintér)
Éva Renner
From the Department of Pharmacology and Pharmacotherapy, Medical School and Molecular Pharmacology Research Group, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Kormos, Kecskés, Alomari, Hegedüs, Helyes, Pintér); the Department of Anatomy, Medical School and Research Group for Mood Disorders, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Farkas, T. Gaszner, Csernus, Hegedüs, B. Gaszner); Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary (Renner, Palkovits); the Department of Physiology, Medical School, Szentágothai Research Centre, Centre for Neuroscience, University of Pécs, Pécs, Hungary (Zelena); Pharm-InVivo Ltd., Pécs, Hungary (Helyes, Pintér)
Miklós Palkovits
From the Department of Pharmacology and Pharmacotherapy, Medical School and Molecular Pharmacology Research Group, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Kormos, Kecskés, Alomari, Hegedüs, Helyes, Pintér); the Department of Anatomy, Medical School and Research Group for Mood Disorders, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Farkas, T. Gaszner, Csernus, Hegedüs, B. Gaszner); Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary (Renner, Palkovits); the Department of Physiology, Medical School, Szentágothai Research Centre, Centre for Neuroscience, University of Pécs, Pécs, Hungary (Zelena); Pharm-InVivo Ltd., Pécs, Hungary (Helyes, Pintér)
Dóra Zelena
From the Department of Pharmacology and Pharmacotherapy, Medical School and Molecular Pharmacology Research Group, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Kormos, Kecskés, Alomari, Hegedüs, Helyes, Pintér); the Department of Anatomy, Medical School and Research Group for Mood Disorders, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Farkas, T. Gaszner, Csernus, Hegedüs, B. Gaszner); Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary (Renner, Palkovits); the Department of Physiology, Medical School, Szentágothai Research Centre, Centre for Neuroscience, University of Pécs, Pécs, Hungary (Zelena); Pharm-InVivo Ltd., Pécs, Hungary (Helyes, Pintér)
Zsuzsanna Helyes
From the Department of Pharmacology and Pharmacotherapy, Medical School and Molecular Pharmacology Research Group, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Kormos, Kecskés, Alomari, Hegedüs, Helyes, Pintér); the Department of Anatomy, Medical School and Research Group for Mood Disorders, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Farkas, T. Gaszner, Csernus, Hegedüs, B. Gaszner); Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary (Renner, Palkovits); the Department of Physiology, Medical School, Szentágothai Research Centre, Centre for Neuroscience, University of Pécs, Pécs, Hungary (Zelena); Pharm-InVivo Ltd., Pécs, Hungary (Helyes, Pintér)
Erika Pintér
From the Department of Pharmacology and Pharmacotherapy, Medical School and Molecular Pharmacology Research Group, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Kormos, Kecskés, Alomari, Hegedüs, Helyes, Pintér); the Department of Anatomy, Medical School and Research Group for Mood Disorders, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Farkas, T. Gaszner, Csernus, Hegedüs, B. Gaszner); Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary (Renner, Palkovits); the Department of Physiology, Medical School, Szentágothai Research Centre, Centre for Neuroscience, University of Pécs, Pécs, Hungary (Zelena); Pharm-InVivo Ltd., Pécs, Hungary (Helyes, Pintér)
Balázs Gaszner
From the Department of Pharmacology and Pharmacotherapy, Medical School and Molecular Pharmacology Research Group, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Kormos, Kecskés, Alomari, Hegedüs, Helyes, Pintér); the Department of Anatomy, Medical School and Research Group for Mood Disorders, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Farkas, T. Gaszner, Csernus, Hegedüs, B. Gaszner); Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary (Renner, Palkovits); the Department of Physiology, Medical School, Szentágothai Research Centre, Centre for Neuroscience, University of Pécs, Pécs, Hungary (Zelena); Pharm-InVivo Ltd., Pécs, Hungary (Helyes, Pintér)
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Peptidergic neurons of the Edinger–Westphal nucleus express TRPA1 ion channel that is downregulated both upon chronic variable mild stress in male mice and in humans who died by suicide
Viktória Kormos, Angéla Kecskés, József Farkas, Tamás Gaszner, Valér Csernus, Ammar Alomari, Dániel Hegedüs, Éva Renner, Miklós Palkovits, Dóra Zelena, Zsuzsanna Helyes, Erika Pintér, Balázs Gaszner
J Psychiatry Neurosci May 2022, 47 (3) E162-E175; DOI: 10.1503/jpn.210187
Peptidergic neurons of the Edinger–Westphal nucleus express TRPA1 ion channel that is downregulated both upon chronic variable mild stress in male mice and in humans who died by suicide
Viktória Kormos, Angéla Kecskés, József Farkas, Tamás Gaszner, Valér Csernus, Ammar Alomari, Dániel Hegedüs, Éva Renner, Miklós Palkovits, Dóra Zelena, Zsuzsanna Helyes, Erika Pintér, Balázs Gaszner
J Psychiatry Neurosci May 2022, 47 (3) E162-E175; DOI: 10.1503/jpn.210187
