Large-scale mRNA sequencing determines global regulation of RNA editing during brain development
H Wahlstedt, C Daniel, M Ensterö, M Öhman - Genome research, 2009 - genome.cshlp.org
RNA editing by adenosine deamination has been shown to generate multiple isoforms of
several neural receptors, often with profound effects on receptor function. However, little is …
several neural receptors, often with profound effects on receptor function. However, little is …
Spatiotemporal mapping of RNA editing in the developing mouse brain using in situ sequencing reveals regional and cell-type-specific regulation
E Lundin, C Wu, A Widmark, M Behm, J Hjerling-Leffler… - BMC biology, 2020 - Springer
Background Adenosine-to-inosine (A-to-I) RNA editing is a process that contributes to the
diversification of proteins that has been shown to be essential for neurotransmission and …
diversification of proteins that has been shown to be essential for neurotransmission and …
Dynamic regulation of RNA editing in human brain development and disease
RNA editing is increasingly recognized as a molecular mechanism regulating RNA activity
and recoding proteins. Here we surveyed the global landscape of RNA editing in human …
and recoding proteins. Here we surveyed the global landscape of RNA editing in human …
Complex regulation of ADAR-mediated RNA-editing across tissues
MA Huntley, M Lou, LD Goldstein, M Lawrence… - BMC genomics, 2016 - Springer
Background RNA-editing is a tightly regulated, and essential cellular process for a properly
functioning brain. Dysfunction of A-to-I RNA editing can have catastrophic effects …
functioning brain. Dysfunction of A-to-I RNA editing can have catastrophic effects …
A-to-I RNA editing promotes developmental stage–specific gene and lncRNA expression
B Goldstein, L Agranat-Tamir, D Light… - Genome …, 2017 - genome.cshlp.org
A-to-I RNA editing is a conserved widespread phenomenon in which adenosine (A) is
converted to inosine (I) by adenosine deaminases (ADARs) in double-stranded RNA …
converted to inosine (I) by adenosine deaminases (ADARs) in double-stranded RNA …
Accumulation of nuclear ADAR2 regulates adenosine-to-inosine RNA editing during neuronal development
M Behm, H Wahlstedt, A Widmark… - Journal of Cell …, 2017 - journals.biologists.com
Adenosine to inosine (A-to-I) RNA editing is important for a functional brain, and most known
sites that are subject to selective RNA editing have been found to result in diversified protein …
sites that are subject to selective RNA editing have been found to result in diversified protein …
Dynamic landscape and regulation of RNA editing in mammals
Abstract Adenosine-to-inosine (A-to-I) RNA editing is a conserved post-transcriptional
mechanism mediated by ADAR enzymes that diversifies the transcriptome by altering …
mechanism mediated by ADAR enzymes that diversifies the transcriptome by altering …
A comparative analysis of ADAR mutant mice reveals site-specific regulation of RNA editing
PHC Cruz, Y Kato, T Nakahama, T Shibuya… - Rna, 2020 - rnajournal.cshlp.org
Adenosine-to-inosine RNA editing is an essential post-transcriptional modification catalyzed
by adenosine deaminase acting on RNA (ADAR) 1 and ADAR2 in mammals. For numerous …
by adenosine deaminase acting on RNA (ADAR) 1 and ADAR2 in mammals. For numerous …
RNA-interacting proteins act as site-specific repressors of ADAR2-mediated RNA editing and fluctuate upon neuronal stimulation
A Tariq, W Garncarz, C Handl, A Balik… - Nucleic acids …, 2013 - academic.oup.com
RNA editing by adenosine deaminases that act on RNA (ADARs) diversifies the
transcriptome by changing adenosines to inosines. In mammals, editing levels vary in …
transcriptome by changing adenosines to inosines. In mammals, editing levels vary in …
Genetic mapping uncovers cis-regulatory landscape of RNA editing
G Ramaswami, P Deng, R Zhang… - Nature …, 2015 - nature.com
Abstract Adenosine-to-inosine (A-to-I) RNA editing, catalysed by ADAR enzymes conserved
in metazoans, plays an important role in neurological functions. Although the fine-tuning …
in metazoans, plays an important role in neurological functions. Although the fine-tuning …
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