TY - JOUR T1 - Impaired cognitive performance under psychosocial stress in cannabis-dependent men is associated with attenuated precuneus activity JF - Journal of Psychiatry and Neuroscience JO - J Psychiatry Neurosci SP - 88 LP - 97 DO - 10.1503/jpn.190039 VL - 45 IS - 2 AU - Weihua Zhao AU - Kaeli Zimmermann AU - Xinqi Zhou AU - Feng Zhou AU - Meina Fu AU - Christian Dernbach AU - Dirk Scheele AU - Bernd Weber AU - Monika Eckstein AU - René Hurlemann AU - Keith M. Kendrick AU - Benjamin Becker Y1 - 2020/03/01 UR - http://jpn.ca/content/45/2/88.abstract N2 - Background: Deficient regulation of stress plays an important role in the escalation of substance use, addiction and relapse. Accumulating evidence suggests dysregulations in cognitive and reward-related processes and the underlying neural circuitry in cannabis dependence. However, despite the important regulatory role of the endocannabinoid system in the stress response, associations between chronic cannabis use and altered stress processing at the neural level have not been systematically examined.Methods: Against this background, the present functional MRI study examined psychosocial stress processing in cannabis-dependent men (n = 28) and matched controls (n = 23) using an established stress-induction paradigm (Montreal Imaging Stress Task) that combines computerized (adaptive) mental arithmetic challenges with social evaluative threat.Results: During psychosocial stress exposure, but not the no-stress condition, cannabis users demonstrated impaired performance relative to controls. In contrast, levels of experienced stress and cardiovascular stress responsivity did not differ from controls. Functional MRI data revealed that stress-induced performance deteriorations in cannabis users was accompanied by decreased precuneus activity and increased connectivity of this region with the superior frontal gyrus.Limitations: Only male cannabis-dependent users were examined; the generalizability in female users remains to be determined.Conclusion: Together, the present findings provide first evidence for exaggerated stress-induced cognitive performance deteriorations in cannabis users. The neural data suggest that deficient stress-related recruitment of the precuneus may be associated with the deterioration of performance at the behavioural level. ER -