@article {Bu134, author = {Xuan Bu and Chuang Yang and Kaili Liang and Qingxia Lin and Lu Lu and Lianqing Zhang and Hailong Li and Yingxue Gao and Shi Tang and Xiaoxiao Hu and Yanlin Wang and Xinyu Hu and Meihao Wang and Xiaoqi Huang}, title = {Quantitative tractography reveals changes in the corticospinal tract in drug-na{\"\i}ve children with attention-deficit/hyperactivity disorder}, volume = {45}, number = {2}, pages = {134--141}, year = {2020}, doi = {10.1503/jpn.190024}, publisher = {Journal of Psychiatry and Neuroscience}, abstract = {Background: The specific role of the corticospinal tract with respect to inattention and impulsive symptoms in children with attentiondeficit/hyperactivity disorder (ADHD) has been explored in the past. However, to our knowledge, no study has identified the exact regions of the corticospinal tract that are affected in ADHD. We aimed to determine comprehensive alterations in the white matter microstructure of the corticospinal tract and underlying neuropsychological substrates in ADHD.Methods: We recruited 38 drug-na{\"\i}ve children with ADHD and 34 typically developing controls. We employed a tract-based quantitative approach to measure diffusion parameters along the trajectory of the corticospinal tract, and we further correlated alterations with attention and response inhibition measures.Results: Compared with controls, children with ADHD demonstrated significantly lower fractional anisotropy and higher radial diffusivity at the level of cerebral peduncle, and higher fractional anisotropy at the level of the posterior limb of the internal capsule in the right corticospinal tract only. As well, increased fractional anisotropy in the posterior limb of the internal capsule was negatively correlated with continuous performance test attention quotients and positively correlated with reaction time on the Stroop Colour{\textendash}Word Test; increased radial diffusivity in the right peduncle region was positively correlated with omissions in the Stroop test.Limitations: The sample size was relatively small. Moreover, we did not consider the different subtypes of ADHD and lacked sufficient power to analyze subgroup differences. Higher-order diffusion modelling is needed in future white matter studies.Conclusion: We demonstrated specific changes in the right corticospinal tract in children with ADHD. Correlations with measures of attention and response inhibition underscored the functional importance of corticospinal tract disturbance in ADHD.}, issn = {1180-4882}, URL = {https://www.jpn.ca/content/45/2/134}, eprint = {https://www.jpn.ca/content/45/2/134.full.pdf}, journal = {Journal of Psychiatry and Neuroscience} }