PT  - JOURNAL ARTICLE
AU  - Konarski, Jakub Z.
AU  - McIntyre, Roger S.
AU  - Grupp, Larry A.
AU  - Kennedy, Sidney H.
TI  - Is the cerebellum relevant in the circuitry of neuropsychiatric disorders?
DP  - 2005 May 01
TA  - Journal of Psychiatry and Neuroscience
PG  - 178--186
VI  - 30
IP  - 3
4099  - http://jpn.ca/content/30/3/178.short
4100  - http://jpn.ca/content/30/3/178.full
SO  - JPN2005 May 01; 30
AB  - Contemporary mechanistic models of several psychiatric disorders propose abnormalities in the structure and function of distinct neural networks. The cerebellum has both anatomic and functional connections to the prefrontal cortex, the subcortical limbic structures and monoamine-producing brainstem nuclei. Conspicuously, however, the cerebellum has been underemphasized in neuropsychiatric research. A growing confluence of scientific data indicate that the cerebellum may not be irrelevant, which suggests that an integrated model of neuropsychiatric disorders should include a role for the cerebellum and its relevant neural connections. This review summarizes the published data describing and characterizing the putative role of the cerebellum in normal and abnormal mood regulation, with specific attention to states of psychosis, depression and mania. The available evidence suggests that a functional role for the cerebellum should be considered in future neuropsychiatric studies.