TY - JOUR T1 - Comorbidity and pathophysiology of obsessive–compulsive disorder in schizophrenia: Is there evidence for a schizo-obsessive subtype of schizophrenia? JF - Journal of Psychiatry and Neuroscience JO - JPN SP - 187 LP - 195 VL - 30 IS - 3 AU - Alexandra Bottas AU - Robert G. Cooke AU - Margaret A. Richter Y1 - 2005/05/01 UR - http://jpn.ca/content/30/3/187.abstract N2 - Epidemiologic and neurobiologic evidence suggests that patients with comorbid obsessive–compulsive disorder (OCD) and schizophrenia may represent a special category among patients with schizophrenia. Efforts to examine the neurobiology of this group have focused on neuroimaging studies and neuropsychologic testing. Convergent evidence suggests that there may be a specific pattern of neurobiologic dysfunction in this subgroup of patients accounting for symptom co-expression. This review indicates that future studies should distinguish among (1) apparent obsessive–compulsive symptoms (OCS) that occur only in the context of psychosis and that may overlap with psychotic phenomenology, representing a forme fruste of psychosis; (2) OCS occurring only in the prodromal phase of schizophrenia; (3) neuroleptic-induced OCS or OCD; and (4) OCS or frank OCD occurring concurrently with schizophrenia. We examine the evidence for a putative schizo-obsessive disorder and outline suggestions for identifying OCS in the presence of psychosis. ER -