PT - JOURNAL ARTICLE AU - Christian Even AU - Jacques Thuile AU - Johana Santos AU - Patrice Bourgin TI - Modafinil as an adjunctive treatment to sleep deprivation in depression DP - 2005 Nov 01 TA - Journal of Psychiatry and Neuroscience PG - 432--433 VI - 30 IP - 6 4099 - http://jpn.ca/content/30/6/432.short 4100 - http://jpn.ca/content/30/6/432.full SO - JPN2005 Nov 01; 30 AB - Sleep deprivation (SD) is a rapid-acting treatment for depression, but its clinical efficacy is hampered by high relapse rates after recovery sleep, and its effectiveness is reduced by the demanding effort needed for the patient to stay awake. To our knowledge, this is the first reported case of a successful treatment of depression with the combination of SD and the wakefulness-promoting agent modafinil. We suggest that modafinil may reinforce the action of SD, possibly by preventing daytime naps and microsleep, and may sustain the antidepressant effect of SD, possibly by stabilizing the resynchronization between the circadian clock and the sleep–wake cycle.