TY - JOUR T1 - Neurocognitive function in an extended Afrikaner-ancestry family with affective illness JF - Journal of Psychiatry and Neuroscience JO - JPN SP - 116 LP - 120 VL - 32 IS - 2 AU - Jonathan Savitz AU - Lize van der Merwe AU - Mark Solms AU - Rajkumar Ramesar Y1 - 2007/03/01 UR - http://jpn.ca/content/32/2/116.abstract N2 - Objective: To characterize the neuropsychological profile of an extended family with unipolar depression (UPD) and other forms of affective illness.Method: We administered a battery of neuropsychological tasks measuring various aspects of executive function and visual and verbal memory to 49 individuals in 1 extended family. Six participants had 1 lifetime episode of major depression (MDE-S), 15 were diagnosed with recurrent major depression (MDE-R), 11 had another DSM-IV diagnosis and 17 subjects were unaffected.Results: After controlling for multiple confounding factors, including mood and medication, the MDE-R sample made significantly more errors than unaffected relatives on the Stroop Task, a measure of cognitive control.Conclusion: There may be at least 1 subtype of UPD characterized by a state-independent deficit in cognitive control. ER -