RT Journal Article SR Electronic T1 Lithium side-effects and predictors of hypothyroidism in patients with bipolar disorder: sex differences JF Journal of Psychiatry and Neuroscience JO JPN FD Canadian Medical Association SP 104 OP 107 VO 27 IS 2 A1 Chantal Henry YR 2002 UL http://jpn.ca/content/27/2/104.abstract AB Objective: To determine the prevalence of the side effects of lithium therapy and possible predictors of hypothyroidism in women and men with bipolar disorder.Method: Twenty-two men and 38 women with bipolar disorder and taking lithium for at least 1 year, were interviewed about lithium side effects using a list of the most commonly reported symptoms.Results: The complaint most frequently reported was polyuria–polydipsia syndrome, which affected 36 (60%) of 60 patients. More men than women reported tremor (54% v. 26%, p < 0.05), but weight gain during the first year of treatment was more frequent in women than men (47% v. 18%, p < 0.05), as was the development of clinical hypothyroidism (37% v. 9%, p < 0.05). Weight gain during the first year of treatment (and not sex) was the only significant predictor of hypothyroidism.Conclusion: Weight gain during the first year of lithium treatment, in the absence of biological evidence of subclinical hypothyroidism, was the most predictive and, possibly, the first sign of hypothyroidism.