@article {Bourin178, author = {Michel Bourin and Martine Hasco{\"e}t and Marie Claude Colombel and Ronald T. Coutts and Glen B. Baker}, title = {Clonidine potentiates the effects of tranylcypromine, phenelzine and two analogues in the forced swimming test in mice}, volume = {27}, number = {3}, pages = {178--185}, year = {2002}, publisher = {Journal of Psychiatry and Neuroscience}, abstract = {Objective: To compare tranylcypromine (TCP) and phenelzine (PLZ), two well-established inhibitors of monoamine oxidase (MAO), and 2 of their analogues, 4-fluorotranylcypromine (FTCP) and N2-acetylphenelzine (AcPLZ) respectively, with regard to effects in the forced swimming test, a behavioural test used to screen for potential antidepressant drugs.Methods: Mice were dropped individually into glass cylinders containing water. The duration of their immobility was scored during the last 4 minutes of the test.Results: Except for TCP at high doses, none of the drugs demonstrated activity when administered alone. All 4 drugs were active when given in combination with clonidine, an effect thought to be the result of mixed action at 5-HT1A and 5-HT2 receptors and the noradrenergic system. 5-HT1B receptors do not seem to be implicated, as lithium did not potentiate the effect of any of the drugs. Quinine activation of AcPLZ suggests that this analogue acts on 5-HT3 receptors.Conclusions: FTCP and AcPLZ demonstrated anti-immobility activity in the forced swimming test when used in association clonidine. These findings confirm previous neurochemical findings suggesting that these drugs have antidepressant properties.}, issn = {1180-4882}, URL = {https://www.jpn.ca/content/27/3/178}, eprint = {https://www.jpn.ca/content/27/3/178.full.pdf}, journal = {Journal of Psychiatry and Neuroscience} }