PT  - JOURNAL ARTICLE
AU  - Alelú-Paz, Raúl
AU  - Giménez-Amaya, José Manuel
TI  - The mediodorsal thalamic nucleus and schizophrenia
DP  - 2008 Nov 01
TA  - Journal of Psychiatry and Neuroscience
PG  - 489--498
VI  - 33
IP  - 6
4099  - http://jpn.ca/content/33/6/489.short
4100  - http://jpn.ca/content/33/6/489.full
SO  - JPN2008 Nov 01; 33
AB  - The mediodorsal nucleus of the human thalamus is in a crucial position that allows it to establish connections with diverse cerebral structures, particularly the prefrontal cortex. The present review examines existing neurobiologic studies of the brains of people with and without schizophrenia that indicate a possible involvement of the mediodorsal nucleus in this psychiatric disorder. Studies at synaptic and cellular levels of the neurobiology of the mediodorsal nucleus, together with a better anatomic understanding of this diencephalic structure owing to neuroimaging studies, should help to establish a more deep and solid pathophysiologic model of schizophrenia.