PT - JOURNAL ARTICLE AU - Simon N. Young AU - Debbie S. Moskowitz AU - Marije aan het Rot TI - Possible role of more positive social behaviour in the clinical effect of antidepressant drugs AID - 10.1503/jpn.130165 DP - 2014 Jan 01 TA - Journal of Psychiatry and Neuroscience PG - 60--65 VI - 39 IP - 1 4099 - http://jpn.ca/content/39/1/60.short 4100 - http://jpn.ca/content/39/1/60.full SO - J Psychiatry Neurosci2014 Jan 01; 39 AB - Increasing serotonin decreases quarrelsome behaviours and enhances agreeable behaviours in humans. Antidepressants, even those whose primary action is not on serotonin, seem to increase serotonin function. We suggest that antidepressants act in part by effects on social behaviour, which leads to a gradual improvement in mood. We review the evidence supporting the idea that anti-depressants may be moving behaviour from quarrelsome to agreeable. The more positive social responses of interaction partners would initiate a cycle of more positive social behaviour, and this iterative process would result in a clinically significant improvement in mood.