PT  - JOURNAL ARTICLE
AU  - Shantel L. Duffy
AU  - Matt Paradise
AU  - Ian B. Hickie
AU  - Simon J.G. Lewis
AU  - Sharon L. Naismith
AU  - Jim Lagopoulos
TI  - Cognitive impairment with and without depression history: an analysis of white matter microstructure
AID  - 10.1503/jpn.130079
DP  - 2014 Mar 01
TA  - Journal of Psychiatry and Neuroscience
PG  - 135--143
VI  - 39
IP  - 2
4099  - http://jpn.ca/content/39/2/135.short
4100  - http://jpn.ca/content/39/2/135.full
SO  - J Psychiatry Neurosci2014 Mar 01; 39
AB  - Background: Mild cognitive impairment (MCI) and late-life depression are clinical syndromes that often co-occur and may represent an early manifestation of neurodegenerative disease. The present study examined white matter microstructure in patients with MCI with and without a history of major depression compared with healthy controls.Methods: Older adults with MCI and no history of major depression (MCI), adults with MCI and euthymic major depression (MCI-MD) and healthy controls underwent comprehensive medical, psychiatric and neuropsychological assessments. Participants also underwent diffusion tensor imaging, which was analyzed using tract-based spatial statistics. White matter hyperintensity (WMH) burden and medical burden were also quantified.Results: We enrolled 30 participants in the MCI group, 36 in the MCI-MD group and 22 in the control group. Compared with controls, participants in the MCI group had significantly reduced fractional anisotropy (FA) in the corpus callosum, superior longitudinal fasciculus (SLF), corona radiata and posterior thalamic radiation. Participants in the MCI-MD group had significantly reduced FA in the corpus callosum, internal capsule, external capsule, corona radiata, posterior thalamic radiation, sagittal striatum, fornix, SLF, uncinate fasciculus and right cingulum compared with controls. No significant differences in FA were observed between the MCI and MCI-MD groups. Participants in the MCI-MD group had greater medical burden (p = 0.020) and WMH burden than controls (p = 0.013).Limitations: Study limitations include the cross-sectional design and antidepressant medication use.Conclusion: To our knowledge, this study is the first to compare white matter microstructure in patients with MCI with and without a history of major depression and suggests that a common underlying structural white matter change may underpin cognitive impairment in both MCI groups. Further research is needed to delineate the pathophysiological mechanisms underlying these microstructural changes.