PT  - JOURNAL ARTICLE
AU  - Gary Remington
AU  - Gagan Fervaha
AU  - George Foussias
AU  - Ofer Agid
AU  - Peter Turrone
TI  - 2012 CCNP Innovations Award Paper: Antipsychotic dosing: found in translation
AID  - 10.1503/jpn.130191
DP  - 2014 Jul 01
TA  - Journal of Psychiatry and Neuroscience
PG  - 223--231
VI  - 39
IP  - 4
4099  - http://jpn.ca/content/39/4/223.short
4100  - http://jpn.ca/content/39/4/223.full
SO  - J Psychiatry Neurosci2014 Jul 01; 39
AB  - In the field of schizophrenia research, as in other areas of psychiatry, there is a sense of frustration that greater advances have not been made over the years, calling into question existing research strategies. Arguably, many purported gains claimed by research have been “lost in translation,” resulting in limited impact on diagnosis and treatment in the clinical setting. There are exceptions; for example, we would argue that different lines of preclinical and clinical research have substantially altered how we look at antipsychotic dosing. While this story remains a work in progress, advances “found in translation” have played an important role. Detailing these changes, the present paper speaks to a body of evidence that has already shifted clinical practice and raises questions that may further alter the manner in which antipsychotics have been administered over the last 6 decades.