RT Journal Article
SR Electronic
T1 2012 CCNP Innovations Award Paper: Antipsychotic dosing: found in translation
JF Journal of Psychiatry and Neuroscience
JO J Psychiatry Neurosci
FD Canadian Medical Association
SP 223
OP 231
DO 10.1503/jpn.130191
VO 39
IS 4
A1 Remington, Gary
A1 Fervaha, Gagan
A1 Foussias, George
A1 Agid, Ofer
A1 Turrone, Peter
YR 2014
UL http://jpn.ca/content/39/4/223.abstract
AB In the field of schizophrenia research, as in other areas of psychiatry, there is a sense of frustration that greater advances have not been made over the years, calling into question existing research strategies. Arguably, many purported gains claimed by research have been “lost in translation,” resulting in limited impact on diagnosis and treatment in the clinical setting. There are exceptions; for example, we would argue that different lines of preclinical and clinical research have substantially altered how we look at antipsychotic dosing. While this story remains a work in progress, advances “found in translation” have played an important role. Detailing these changes, the present paper speaks to a body of evidence that has already shifted clinical practice and raises questions that may further alter the manner in which antipsychotics have been administered over the last 6 decades.