TY - JOUR T1 - Uncovering neurodevelopmental paths to autism spectrum disorder through an integrated analysis of developmental measures and neural sensitivity to faces JF - Journal of Psychiatry and Neuroscience JO - JPN SP - E34 LP - E43 DO - 10.1503/jpn.190148 VL - 46 IS - 1 AU - Giorgia Bussu AU - Alberto Llera AU - Emily J.H. Jones AU - Charlotte Tye AU - Tony Charman AU - Mark H. Johnson AU - Christian F. Beckmann AU - Jan K. Buitelaar Y1 - 2021/01/01 UR - http://jpn.ca/content/46/1/E34.abstract N2 - Background Autism spectrum disorder (ASD) is highly heterogeneous in its etiology and manifestation. The neurobiological processes underlying ASD development are reflected in multiple features, from behaviour and cognition to brain functioning. An integrated analysis of these features may optimize the identification of these processes.Methods We examined cognitive and adaptive functioning and ASD symptoms between 8 and 36 months in 161 infants at familial high risk for ASD and 71 low-risk controls; we also examined neural sensitivity to eye gaze at 8 months in a subsample of 140 high-risk and 61 low-risk infants. We used linked independent component analysis to extract patterns of variation across domains and development, and we selected the patterns significantly associated with clinical classification at 36 months.Results An early process at 8 months, indicating high levels of functioning and low levels of symptoms linked to higher attention to gaze shifts, was reduced in infants who developed ASD. A longitudinal process of increasing functioning and low levels of symptoms was reduced in infants who developed ASD, and another process suggesting a stagnation in cognitive functioning at 24 months was increased in infants who developed ASD.Limitations Although the results showed a clear significant trend relating to clinical classification, we found substantial overlap between groups.Conclusion We uncovered underlying processes that acted together early in development and were associated with clinical outcomes. Our results highlighted the complexity of emerging ASD, which goes beyond the borders of clinical categories. Future work should integrate genetic data to investigate the specific genetic risks linked to these processes. ER -