RT Journal Article
SR Electronic
T1 <em>Monoamine oxidase-A</em> polymorphisms might modify the association between the <em>dopamine D</em><em><sub>2</sub></em><em> receptor</em> gene and alcohol dependence
JF Journal of Psychiatry and Neuroscience
JO JPN
FD Canadian Medical Association
SP 185
OP 192
VO 32
IS 3
A1 San-Yuan Huang
A1 Wei-Wen Lin
A1 Fang-Jung Wan
A1 Ai-Ju Chang
A1 Huei-Chen Ko
A1 Tso-Jen Wang
A1 Pei-Lin Wu
A1 Ru-Band Lu
YR 2007
UL http://jpn.ca/content/32/3/185.abstract
AB Objective: Low monoamine oxidase (MAO) activity and the neurotransmitter dopamine are 2 important factors in the development of alcohol dependence. MAO is an important enzyme associated with the metabolism of biogenic amines. Therefore, the present study investigates whether the association between the dopamine D2 receptor (DRD2) gene and alcoholism is affected by different polymorphisms of the MAO type A (MAOA) gene.Methods: A total of 427 Han Chinese men in Taiwan (201 control subjects and 226 with alcoholism) were recruited for the study. Of the subjects with alcoholism, 108 had pure alcohol dependence (ALC) and 118 had both alcohol dependence and anxiety, depression or both (ANX/DEP ALC). All subjects were assessed with the Chinese Version of the Modified Schedule of Affective Disorders and Schizophrenia-Lifetime. Alcohol dependence, anxiety and major depressive disorders were diagnosed according to Diagnostic and Statistical Manual of Mental Disorders, fourth edition criteria.Conclusion: The genetic variant of the DRD2 gene was only associated with the ANX/DEP ALC phenotype, and the genetic variant of the MAOA gene was associated with pure ALC. Subjects carrying the MAOA 3-repeat allele and genotype A1/A1 of the DRD2 were 3.48 times (95% confidence interval = 1.47–8.25) more likely to be ANX/DEP ALC than the subjects carrying the MAOA 3-repeat allele and DRD2 A2/A2 genotype. The MAOA gene may modify the association between the DRD2 gene and ANX/DEP ALC phenotype.