RT Journal Article
SR Electronic
T1 Amygdala reactivity to masked negative faces is associated with automatic judgmental bias in major depression: a 3 T fMRI study
JF Journal of Psychiatry and Neuroscience
JO JPN
FD Canadian Medical Association
SP 423
OP 429
VO 32
IS 6
A1 Udo Dannlowski
A1 Patricia Ohrmann
A1 Jochen Bauer
A1 Harald Kugel
A1 Volker Arolt
A1 Walter Heindel
A1 Anette Kersting
A1 Bernhard T. Baune
A1 Thomas Suslow
YR 2007
UL http://jpn.ca/content/32/6/423.abstract
AB Objective: In a previous study, we demonstrated that amygdala reactivity to masked negative facial emotions predicts negative judgmental bias in healthy subjects. In the present study, we extended the paradigm to a sample of 35 inpatients suffering from depression to investigate the effect of amygdala reactivity on automatic negative judgmental bias and clinical characteristics in depression.Methods: Amygdala activity was recorded in response to masked displays of angry, sad and happy facial expressions by means of functional magnetic resonance imaging at 3 T. In a subsequent experiment, the patients performed an affective priming task that characterizes automatic emotion processing by investigating the biasing effect of subliminally presented emotional faces on evaluative ratings to subsequently presented neutral stimuli.Results: Significant associations between (right) amygdala reactivity and automatic negative judgmental bias were replicated in our patient sample (r = −0.59, p < 0.001). Further, negatively biased evaluative processing was associated with severity and longer course of illness (r = −0.57, p = 0.001).Conclusion: Amygdala hyperactivity is a neural substrate of negatively biased automatic emotion processing that could be a determinant for a more severe disease course.