TY - JOUR T1 - Corpus callosum abnormalities in women with borderline personality disorder and comorbid attention-deficit hyperactivity disorder JF - Journal of Psychiatry and Neuroscience JO - JPN SP - 417 LP - 422 VL - 32 IS - 6 AU - Nicolas RĂ¼sch AU - Eileen Luders AU - Klaus Lieb AU - Roland Zahn AU - Dieter Ebert AU - Paul M. Thompson AU - Arthur W. Toga AU - Ludger Tebartz van Elst Y1 - 2007/11/01 UR - http://jpn.ca/content/32/6/417.abstract N2 - Objective: Decreased brain volumes in prefrontal, limbic and parietal areas have been found in women with borderline personality disorder (BPD). Recent models suggest impaired structural and functional connectivity in this condition. To investigate this, we studied the thickness of the corpus callosum, the largest connecting fibre bundle in the human brain.Methods: We acquired magnetic resonance imaging scans from 20 healthy women and 20 women with BPD and comorbid attention-deficit hyperactivity disorder. A novel computational mesh-based method was applied to measure callosal thickness at high spatial resolution.Results: Women with BPD had a thinner isthmus of the corpus callosum, compared with healthy women. In the patient group, a history of childhood sexual abuse was associated with a thinner posterior body of the corpus callosum.Conclusion: Interhemispheric structural connectivity involving parietal and temporal areas may be impaired in women with BPD and comorbid attention-deficit hyperactivity disorder. ER -