%0 Journal Article %A Michael Tseng %A Martin Alda %A Li Xu %A Xiujun Sun %A Jun-Feng Wang %A Paul Grof %A Gustavo Turecki %A Guy Rouleau %A L. Trevor Young %T BDNF protein levels are decreased in transformed lymphoblasts from lithium-responsive patients with bipolar disorder %D 2008 %J Journal of Psychiatry and Neuroscience %P 449-453 %V 33 %N 5 %X Objective: Brain-derived neurotrophic factor (BDNF) is a key factor in neuroplasticity and has been implicated in the affective disorders; studies have demonstrated elevated BDNF in patients taking lithium and other mood stabilizers. The objective of our study was to analyze BDNF in lithium-responsive patients with bipolar disorder (BD) to further understand the role of BDNF in the pathophysiology of BD.Methods: Using enzyme-linked immunosorbent assay, we measured transformed B lymphocytes for BDNF protein.Results: BDNF levels were 36% lower in lymphoblasts from patients with BD (n = 12), compared with matched control participants (n = 13), and 55% lower when compared with their unaffected relatives (n = 14). Lithium significantly decreased BDNF levels in patients with BD and healthy control participants, although BDNF levels remained lower (33%) in the BD group posttreatment.Conclusion: Decreased BDNF may constitute part of the pathophysiologic process of BD in a lithium-responsive subgroup of individuals with this disease. A compensatory mechanism protecting the genetically predisposed unaffected relatives from phenotypic expression of BD is suggested. %U https://www.jpn.ca/content/jpn/33/5/449.full.pdf