RT Journal Article
SR Electronic
T1 The risk for major depression conferred by childhood maltreatment is multiplied by <em>BDNF</em> and <em>SERT</em> genetic vulnerability: a replication study
JF Journal of Psychiatry and Neuroscience
JO J Psychiatry Neurosci
FD Canadian Medical Association
SP 187
OP 196
DO 10.1503/jpn.140097
VO 40
IS 3
A1 Gutiérrez, Blanca
A1 Bellón, Juan Ángel
A1 Rivera, Margarita
A1 Molina, Esther
A1 King, Michael
A1 Marston, Louise
A1 Torres-González, Francisco
A1 Moreno-Küstner, Berta
A1 Moreno-Peral, Patricia
A1 Motrico, Emma
A1 Montón-Franco, Carmen
A1 GildeGómez-Barragán, María Josefa
A1 Sánchez-Celaya, Marta
A1 Díaz-Barreiros, Miguel Ángel
A1 Vicens, Catalina
A1 de Dios Luna, Juan
A1 Nazareth, Irwin
A1 Cervilla, Jorge
YR 2015
UL http://jpn.ca/content/40/3/187.abstract
AB Background: There is limited evidence for a moderating role of both serotonin transporter (SERT) and brain-derived neurotrophic factor (BDNF) genes on the risk for major depression (MD) developing after childhood maltreatment. However, research on this topic remains inconclusive, and there is a lack of data from longitudinal studies with large and representative population samples. Our study aimed to clarify whether, in the presence of previous childhood maltreatment, individuals carrying low functional alleles for both SERT 5-HTTLPR and BDNF Val66Met polymorphisms had a higher risk for MD.Methods: We explored 2- and 3-way gene (SERT and BDNF) × environment (childhood maltreatment) interactions in a large sample of Spanish adults who were followed up over a 3-year period and assessed in person for both DSM-IV MD and exposure to childhood maltreatment.Results: Our study included 2679 participants. Those with both the 5-HTTLPR s allele and the BDNF Met allele showed the highest risk of MD if they had previously experienced emotional (z = 2.08, p = 0.037), sexual (z = 2.19, p = 0.029) or any kind of childhood abuse (z = 2.37, p = 0.018). These 3-way interactions remained significant regardless of whether the 5-HTTLPR triallelic or the 5-HTTLPR biallelic polymorphisms were included in the analyses.Limitations: Retrospective assessment of childhood maltreatment may have resulted in a moderate degree of recall bias.Conclusion: Our results confirm that the risk of depression conferred by childhood maltreatment is modified by variation at both SERT and BDNF genes.