RT Journal Article
SR Electronic
T1 Corpus callosum area in patients with bipolar disorder with and without psychotic features: an international multicentre study
JF Journal of Psychiatry and Neuroscience
JO J Psychiatry Neurosci
FD Canadian Medical Association
SP 352
OP 359
DO 10.1503/jpn.140262
VO 40
IS 5
A1 Samuel Sarrazin
A1 Marc-Antoine d’Albis
A1 Colm McDonald
A1 Julia Linke
A1 Michèle Wessa
A1 Mary Phillips
A1 Marine Delavest
A1 Louise Emsell
A1 Amelia Versace
A1 Jorge Almeida
A1 Jean-François Mangin
A1 Cyril Poupon
A1 Katia Le Dudal
A1 Claire Daban
A1 Nora Hamdani
A1 Marion Leboyer
A1 Josselin Houenou
YR 2015
UL http://jpn.ca/content/40/5/352.abstract
AB Background: Previous studies have reported MRI abnormalities of the corpus callosum (CC) in patients with bipolar disorder (BD), although only a few studies have directly compared callosal areas in psychotic versus nonpsychotic patients with this disorder. We sought to compare regional callosal areas in a large international multicentre sample of patients with BD and healthy controls.Methods: We analyzed anatomic T1 MRI data of patients with BD-I and healthy controls recruited from 4 sites (France, Germany, Ireland and the United States). We obtained the mid-sagittal areas of 7 CC subregions using an automatic CC delineation. Differences in regional callosal areas between patients and controls were compared using linear mixed models (adjusting for age, sex, handedness, brain volume, history of alcohol abuse/dependence, lithium or antipsychotic medication status, symptomatic status and site) and multiple comparisons correction. We also compared regional areas of the CC between patients with BD with and without a history of psychotic features.Results: We included 172 patients and 146 controls in our study. Patients with BD had smaller adjusted mid-sagittal CC areas than controls along the posterior body, the isthmus and the splenium of the CC. Patients with a positive history of psychotic features had greater adjusted area of the rostral CC region than those without a history of psychotic features.Limitations: We found small to medium effect sizes, and there was no calibration technique among the sites.Conclusion: Our results suggest that BD with psychosis is associated with a different pattern of interhemispheric connectivity than BD without psychosis and could be considered a relevant neuroimaging subtype of BD.