RT Journal Article
SR Electronic
T1 The Canadian Biomarker Integration Network in Depression (CAN-BIND): magnetic resonance imaging protocols
JF Journal of Psychiatry and Neuroscience
JO J Psychiatry Neurosci
FD Canadian Medical Association
SP 223
OP 236
DO 10.1503/jpn.180036
VO 44
IS 4
A1 Glenda M. MacQueen
A1 Stefanie Hassel
A1 Stephen R. Arnott
A1 Jean Addington
A1 Christopher R. Bowie
A1 Signe L. Bray
A1 Andrew D. Davis
A1 Jonathan Downar
A1 Jane A. Foster
A1 Benicio N. Frey
A1 Benjamin I. Goldstein
A1 Geoffrey B. Hall
A1 Kate L. Harkness
A1 Jacqueline Harris
A1 Raymond W. Lam
A1 Catherine Lebel
A1 Roumen Milev
A1 Daniel J. Müller
A1 Sagar V. Parikh
A1 Sakina Rizvi
A1 Susan Rotzinger
A1 Gulshan B. Sharma
A1 Claudio N. Soares
A1 Gustavo Turecki
A1 Fidel Vila-Rodriguez
A1 Joanna Yu
A1 Mojdeh Zamyadi
A1 Stephen C. Strother
A1 Sidney H. Kennedy
A1 ,
YR 2019
UL http://jpn.ca/content/44/4/223.abstract
AB Studies of clinical populations that combine MRI data generated at multiple sites are increasingly common. The Canadian Biomarker Integration Network in Depression (CAN-BIND; www.canbind.ca) is a national depression research program that includes multimodal neuroimaging collected at several sites across Canada. The purpose of the current paper is to provide detailed information on the imaging protocols used in a number of CAN-BIND studies. The CAN-BIND program implemented a series of platform-specific MRI protocols, including a suite of prescribed structural and functional MRI sequences supported by real-time monitoring for adherence and quality control. The imaging data are retained in an established informatics and databasing platform. Approximately 1300 participants are being recruited, including almost 1000 with depression. These include participants treated with antidepressant medications, transcranial magnetic stimulation, cognitive behavioural therapy and cognitive remediation therapy. Our ability to analyze the large number of imaging variables available may be limited by the sample size of the substudies. The CAN-BIND program includes a multimodal imaging database supported by extensive clinical, demographic, neuropsychological and biological data from people with major depression. It is a resource for Canadian investigators who are interested in understanding whether aspects of neuroimaging — alone or in combination with other variables — can predict the outcomes of various treatment modalities.