TY - JOUR T1 - Ketamine for chronic depression: two cautionary tales JF - Journal of Psychiatry and Neuroscience JO - J Psychiatry Neurosci SP - 384 LP - 385 DO - 10.1503/jpn.190073 VL - 44 IS - 6 AU - Jeanne Talbot AU - Jennifer L. Phillips AU - Pierre Blier Y1 - 2019/11/01 UR - http://jpn.ca/content/44/6/384.abstract N2 - A growing body of literature has shown the effectiveness of ketamine for treating chronic depression. How long the beneficial effects of repeated ketamine last once infusions are stopped, however, remains largely unknown. Understanding the challenges that ensue after ketamine cessation can help clinicians optimally guide patients who opt for ketamine treatment and minimize the associated risks. In this commentary, we discuss some unexpected data gathered from participants of a pilot study on the effects of adjunctive ketamine infusion for resistant depression. ER -