PT  - JOURNAL ARTICLE
AU  - Shuai Wang
AU  - Gaolang Gong
AU  - Suyu Zhong
AU  - Jia Duan
AU  - Zhiyang Yin
AU  - Miao Chang
AU  - Shengnan Wei
AU  - Xiaowei Jiang
AU  - Yifang Zhou
AU  - Yanqing Tang
AU  - Fei Wang
TI  - Neurobiological commonalities and distinctions among 3 major psychiatric disorders: a graph theoretical analysis of the structural connectome
AID  - 10.1503/jpn.180162
DP  - 2020 Jan 01
TA  - Journal of Psychiatry and Neuroscience
PG  - 15--22
VI  - 45
IP  - 1
4099  - http://jpn.ca/content/45/1/15.short
4100  - http://jpn.ca/content/45/1/15.full
SO  - J Psychiatry Neurosci2020 Jan 01; 45
AB  - Background: White matter network alterations have increasingly been implicated in major depressive disorder, bipolar disorder and schizophrenia. The aim of this study was to identify shared and distinct white matter network alterations among the 3 disorders.Methods: We used analysis of covariance, with age and gender as covariates, to investigate white matter network alterations in 123 patients with schizophrenia, 123 with bipolar disorder, 124 with major depressive disorder and 209 healthy controls.Results: We found significant group differences in global network efficiency (F = 3.386, p = 0.018), nodal efficiency (F = 8.015, p < 0.001 corrected for false discovery rate [FDR]) and nodal degree (F = 5.971, pFDR < 0.001) in the left middle occipital gyrus, as well as nodal efficiency (F = 6.930, pFDR < 0.001) and nodal degree (F = 5.884, pFDR < 0.001) in the left postcentral gyrus. We found no significant alterations in patients with major depressive disorder. Post hoc analyses revealed that compared with healthy controls, patients in the schizophrenia and bipolar disorder groups showed decreased global network efficiency, nodal efficiency and nodal degree in the left middle occipital gyrus. Furthermore, patients in the schizophrenia group showed decreased nodal efficiency and nodal degree in the left postcentral gyrus compared with healthy controls.Limitations: Our findings could have been confounded in part by treatment differences.Conclusion: Our findings implicate graded white matter network alterations across the 3 disorders, enhancing our understanding of shared and distinct pathophysiological mechanisms across diagnoses and providing vital insights into neuroimaging-based methods for diagnosis and research.