TY - JOUR T1 - Anatomic alterations across amygdala subnuclei in medication-free patients with obsessive–compulsive disorder JF - Journal of Psychiatry and Neuroscience JO - J Psychiatry Neurosci SP - 334 LP - 343 DO - 10.1503/jpn.190114 VL - 45 IS - 5 AU - Lianqing Zhang AU - Xinyu Hu AU - Lu Lu AU - Bin Li AU - Xiaoxiao Hu AU - Xuan Bu AU - Hailong Li AU - Shi Tang AU - Yingxue Gao AU - Yanchun Yang AU - John A. Sweeney AU - Qiyong Gong AU - Xiaoqi Huang Y1 - 2020/09/01 UR - http://jpn.ca/content/45/5/334.abstract N2 - Background: The amygdala has been implicated in obsessive–compulsive disorder (OCD), a common, disabling illness. However, the regional distribution of anatomic alterations in this structure and their association with the symptoms of OCD remains to be established.Methods: We collected high-resolution 3D T1-weighted images from 81 untreated patients with OCD and no lifetime history of comorbid psychotic, affective or anxiety disorders, and from 95 age- and sex-matched healthy controls. We extracted the volume of the central nucleus of the amygdala (CeA) and the basolateral complex of the amygdala (BLA) and compared them across groups using FreeSurfer 6.0. In exploratory analyses, we evaluated other subnuclei, including the cortical medial nuclei, the anterior amygdaloid area, and the corticoamygdaloid transition area.Results: Patients with OCD had reduced amygdala volume bilaterally compared with healthy controls (left, p = 0.034; right, p = 0.002). Volume reductions were greater in the CeA (left: −11.9%, p = 0.002; right: −13.3%, p < 0.001) than in the BLA (left lateral nucleus: −3.3%, p = 0.029; right lateral nucleus: −3.9%, p = 0.018; right basal nucleus: −4.1%, p = 0.017; left accessory basal nucleus: −6.5%, p = 0.001; right accessory basal nucleus: −9.3%, p < 0.001). Volume reductions in the CeA were associated with illness duration. Exploratory analysis revealed smaller medial (left: −15.4%, p < 0.001, η2 = 0.101) and cortical (left: −9.1%, p = 0.001, η2 = 0.058; right: −15.4%, p < 0.001, η2 = 0.175) nuclei in patients with OCD compared with healthy controls.Limitations: Although the strict exclusion criteria used in the study helped us to identify OCD-specific alterations, they may have limited generalizability to the broader OCD population.Conclusion: Our results provide a comprehensive anatomic profile of alterations in the amygdala sub-nuclei in untreated patients with OCD and highlight a distinctive pattern of volume reductions across subnuclei in OCD. Based on the functional properties of the amygdala subnuclei established from preclinical research, CeA impairment may contribute to behavioural inflexibility, and BLA disruption may be responsible for altered fear conditioning and the affective components of OCD. ER -