RT Journal Article
SR Electronic
T1 Shape analysis of the cingulum, uncinate and arcuate fasciculi in patients with bipolar disorder
JF Journal of Psychiatry and Neuroscience
JO J Psychiatry Neurosci
FD Canadian Medical Association
SP 27
OP 36
DO 10.1503/jpn.150291
VO 42
IS 1
A1 Sun, Zhong Yi
A1 Houenou, Josselin
A1 Duclap, Delphine
A1 Sarrazin, Samuel
A1 Linke, Julia
A1 Daban, Claire
A1 Hamdani, Nora
A1 d’Albis, Marc-Antoine
A1 Le Corvoisier, Philippe
A1 Guevara, Pamela
A1 Delavest, Marine
A1 Bellivier, Frank
A1 Almeida, Jorge
A1 Versace, Amelia
A1 Poupon, Cyril
A1 Leboyer, Marion
A1 Phillips, Mary
A1 Wessa, Michèle
A1 Mangin, Jean-François
YR 2017
UL http://jpn.ca/content/42/1/27.abstract
AB Background: Abnormal maturation of brain connectivity is supposed to underlie the dysfunctional emotion regulation in patients with bipolar disorder (BD). To test this hypothesis, white matter integrity is usually investigated using measures of water diffusivity provided by MRI. Here we consider a more intuitive aspect of the morphometry of the white matter tracts: the shape of the fibre bundles, which is associated with neurodevelopment. We analyzed the shape of 3 tracts involved in BD: the cingulum (CG), uncinate fasciculus (UF) and arcuate fasciculus (AF).Methods: We analyzed diffusion MRI data in patients with BD and healthy controls. The fibre bundles were reconstructed using Q-ball–based tractography and automated segmentation. Using Isomap, a manifold learning method, the differences in the shape of the reconstructed bundles were visualized and quantified.Results: We included 112 patients and 82 controls in our analysis. We found the left AF of patients to be further extended toward the temporal pole, forming a tighter hook than in controls. We found no significant difference in terms of shape for the left UF, the left CG or the 3 right fasciculi. However, in patients compared with controls, the ventrolateral branch of the left UF in the orbitofrontal region had a tendency to be larger, and the left CG of patients had a tendency to be smaller in the frontal lobe and larger in the parietal lobe.Limitations: This was a cross-sectional study.Conclusion: Our results suggest neurodevelopmental abnormalities in the left AF in patients with BD. The statistical tendencies observed for the left UF and left CG deserve further study.