PT  - JOURNAL ARTICLE
AU  - Olivier Gay
AU  - Marion Plaze
AU  - Catherine Oppenheim
AU  - Raphael Gaillard
AU  - Jean-Pierre Olié
AU  - Marie-Odile Krebs
AU  - Arnaud Cachia
TI  - Cognitive control deficit in patients with first-episode schizophrenia is associated with complex deviations of early brain development
AID  - 10.1503/jpn.150267
DP  - 2017 Mar 01
TA  - Journal of Psychiatry and Neuroscience
PG  - 87--94
VI  - 42
IP  - 2
4099  - http://jpn.ca/content/42/2/87.short
4100  - http://jpn.ca/content/42/2/87.full
SO  - J Psychiatry Neurosci2017 Mar 01; 42
AB  - Background: Several clinical and radiological markers of early neurodevelopmental deviations have been independently associated with cognitive impairment in patients with schizophrenia. The aim of our study was to test the cumulative and/or interactive effects of these early neurodevelopmental factors on cognitive control (CC) deficit, a core feature of schizophrenia.Methods: We recruited patients with first-episode schizophrenia-spectrum disorders, who underwent structural MRI. We evaluated CC efficiency using the Trail Making Test (TMT). Several markers of early brain development were measured: neurological soft signs (NSS), handedness, sulcal pattern of the anterior cingulate cortex (ACC) and ventricle enlargement.Results: We included 41 patients with schizophrenia in our analysis, which revealed a main effect of ACC morphology (p = 0.041) as well as interactions between NSS and ACC morphology (p = 0.005), between NSS and handedness (p = 0.044) and between ACC morphology and cerebrospinal fluid (CSF) volume (p = 0.005) on CC measured using the TMT-B score – the TMT-A score.Limitations: No 3- or 4-way interactions were detected between the 4 neurodevelopmental factors. The sample size was clearly adapted to detect main effects and 2-way interactions, but may have limited the statistical power to investigate higher-order interactions. The effects of treatment and illness duration were limited as the study design involved only patients with first-episode psychosis.Conclusion: To our knowledge, our study provides the first evidence of cumulative and interactive effects of different neurodevelopmental markers on CC efficiency in patients with schizophrenia. Such findings, in line with the neurodevelopmental model of schizophrenia, support the notion that CC impairments in patients with schizophrenia may be the final common pathway of several early neurodevelopmental mechanisms.