@article {Wium-Andersen320, author = {Ida Kim Wium-Andersen and Marie Kim Wium-Andersen and Martin Balslev J{\o}rgensen and Merete Osler}, title = {Anti-inflammatory treatment and risk for depression after first-time stroke in a cohort of 147 487 Danish patients}, volume = {42}, number = {5}, pages = {320--330}, year = {2017}, doi = {10.1503/jpn160244}, publisher = {Journal of Psychiatry and Neuroscience}, abstract = {Background: Depression is a common complication after stroke, and inflammation may be a pathophysiological mechanism. This study examines whether anti-inflammatory treatment with acetylsalicylic acid (ASA), nonsteroid anti-inflammatory drugs (NSAIDs) or statins influence the risk of depression after stroke.Methods: A register-based cohort including all patients admitted to hospital with a first-time stroke from Jan. 1, 2001, through Dec. 31, 2011, and a nonstroke population with a similar age and sex distribution was followed for depression until Dec. 31, 2014. Depression was defined as having a hospital contact with depression or having filled prescriptions for anti-depressant medication. The associations between redeemed prescriptions of ASA, NSAIDs or statins with early- (<= 1 year after stroke or study entry) and late-onset (\> 1 year after stroke or study entry) depression were analyzed using Cox proportional hazard regression.Results: We identified 147 487 patients with first-time stroke and 160 235 individuals without stroke for inclusion in our study. Redeemed prescriptions of ASA, NSAIDs or statins after stroke decreased the risk for early-onset depression, especially in patients with ischemic or severe stroke. Patients who received a combination of anti-inflammatory treatments had the lowest risk for early-onset depression. On the other hand, use of ASA or NSAIDs 1 year after stroke increased the risk for late-onset depression, whereas statin use was associated with a tendency toward a decreased risk.Limitations: The study used prescription of antidepressant medication as a proxy measure for depression and did not include anti-inflammatory drugs bought over the counter.Conclusion: Anti-inflammatory treatment is associated with a lower risk for depression shortly after stroke but a higher risk for late depression. This suggests that inflammation contributes differently to the development of depression after stroke depending on the time of onset.}, issn = {1180-4882}, URL = {https://www.jpn.ca/content/42/5/320}, eprint = {https://www.jpn.ca/content/42/5/320.full.pdf}, journal = {Journal of Psychiatry and Neuroscience} }