PT  - JOURNAL ARTICLE
AU  - Alasdair M. Barr
AU  - William J. Panenka
AU  - G. William MacEwan
AU  - Allen E. Thornton
AU  - Donna J. Lang
AU  - William G. Honer
AU  - Tania Lecomte
TI  - The need for speed: an update on methamphetamine addiction
DP  - 2006 Sep 01
TA  - Journal of Psychiatry and Neuroscience
PG  - 301--313
VI  - 31
IP  - 5
4099  - http://jpn.ca/content/31/5/301.short
4100  - http://jpn.ca/content/31/5/301.full
SO  - JPN2006 Sep 01; 31
AB  - The psychostimulant methamphetamine (MA) is a highly addictive drug that has surged in popularity over the last decade in North America. A burgeoning number of clandestine drug laboratories has led to dramatic increases in MA production, which have resulted in significant public health, legal and environmental problems. Current evidence indicates that exposure to MA is neurotoxic, and neuroimaging studies confirm that long-term use in humans may lead to extensive neural damage. These physiological changes are commonly associated with persistent forms of cognitive impairment, including deficits in attention, memory and executive function. In the present review, we provide a comprehensive description of the factors relating to MA use and the major health-related consequences, with an emphasis on MA-induced psychosis. It is hoped that increased knowledge of MA abuse will provide the basis for future treatment strategies.